Potential pathway of anti-inflammatory effect by New Zealand honeys

International Journal of General Medicine

Volumn 7, Issue , 2014, Pages 149-158

  Tomblin, Victoria ^a   Ferguson, Lynnette R ^a   Han, Dug Yeo ^a   Murray, Pamela ^a   Schlothauer, Ralf ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Comvita New Zealand Ltd ^*  (New Zealand)

Author keywords

Clover; Inflammatory response; Kanuka; Kunzea ericoides; Leptospermum scoparium; Manuka; Phenolics; Trifolium; Wound healing

Indexed keywords

ANTIINFLAMMATORY AGENT; CASPASE RECRUITMENT DOMAIN PROTEIN 15; HONEY EXTRACT; IBUPROFEN; LIPOPEPTIDE; NATURAL PRODUCT; PHENOL DERIVATIVE; PLANT EXTRACT; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL STRAIN HEK BLUE; CLOVER; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG EFFICACY; EMBRYO; HONEY; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; INTRACELLULAR SIGNALING; KANUKA HONEY; MANUKA HONEY; MAXIMUM INHIBITORY CONCENTRATION; NEW ZEALAND; TREATMENT OUTCOME; WOUND HEALING;

EID: 84897856724     PISSN: None     EISSN: 11787074     Source Type: Book Series    
DOI: 10.2147/IJGM.S45839     Document Type: Article

References (32)

1. Lee DS, Sinno S, Khachemoune A. Honey and wound healing: an overview. Am J Clin Dermatol. 2011;12(3):181-190.
2. Molan PC. Using honey in wound care. IJCA. 2006;3(2):21-24.
3. Molan PC. The role of honey in the management of wounds. J Wound Care. 1999;8(8):415-418.
4. Mathews KA, Binnington AG. Wound management using honey. Compendium for the Continuing Education of the Practicing Veterinarian. 2002;24(1):53-60.
5. Subrahmanyam M. Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. Burns. 1996;22(6): 491-493.
6. Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: a review. J Am Coll Nutr. 2008;27(6):677-689.
7. Khan FR, Ul Abadin Z, Rauf N. Honey: nutritional and medicinal value. Int J Clin Pract. 2007;61(10):1705-1707.
8. Molan PC. Re-introducing honey in the management of wounds and ulcers - theory and practice. Ostomy Wound Manage. 2002;48(11): 28-40.
9. Tonks AJ, Dudley E, Porter NG, et al. A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol. 2007;82(5): 1147-1155.
10. Mwipatayi BP, Angel D, Norrish J, Hamilton MJ, Scott A, Sieunarine K. The use of honey in chronic leg ulcers: a literature review. Primary Intention. 2004;12(3):107-108, 110-112.
11. Steinhorn G, Sims IM, Carnachan SM, Carr AJ, Schlothauer R. Isolation and characterisation of arabinogalactan-proteins from New Zealand kanuka honey. Food Chemistry. 2011;128(4): 949-956.
12. Lund LR, Romer J, Bugge TH, et al. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J. 1999;18(17):4645-4656.
13. Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus HG, Parks WC. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol. 1997;137(6):1445-1457.
14. Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol. 2010;19(8): e73-e79.
15. Schultz GS, Mast BA. Molecular analysis of the environments of healing and chronic wounds: cytokines, proteases and growth factors. Primary Intention. 1999;7(1):7-14.
16. Lee Y, Kim H, Kim S, Kim KH, Chung JH. Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes. Exp Dermatol. 2010;19(8):e44-e49.
17. Chung TW, Moon SK, Chang YC, et al. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J. 2004;18(14):1670-1681.
18. Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas favone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Infamm. 2007;2007:45673.
19. Brandner JM, Zacheja S, Houdek P, Moll I, Lobmann R. Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model. Diabetes Care. 2008;31(1):114-120.
20. Trengove NJ, Stacey MC, MacAuley S, et al. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen. 1999;7(6):442-452.
21. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fbrotic and delayed healing. Front Biosci. 2004;9:283-289.
22. van den Berg AJ, van den Worm E, van Ufford HC, Halkes SB, Hoekstra MJ, Beukelman CJ. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care. 2008;17(4):172-174, 176.
23. Leong AG, Herst PM, Harper JL. Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun. 2012;18(3): 459-466.
24. Kassim M, Achoui M, Mustafa MR, Mohd MA, Yusoff KM. Ellagic acid, phenolic acids, and favonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutr Res. 2010;30(9):650-659.
25. Khalil M, Sulaiman SA, Boukraa L. Antioxidant properties of honey and its role in preventing health disorder. The Open Nutraceuticals Journal. 2010;3(1):6-16.
26. Pyrzynska K, Biesaga M. Analysis of phenolic acids and favonoids in honey. TrAC. 2009;28(7):893-902.
27. Mahgoub AA, el-Medany AH, Hagar HH, Sabah DM. Protective effect of natural honey against acetic acid-induced colitis in rats. Trop Gastroenterol. 2002;23(2):82-87.
28. Medhi B, Prakash A, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats. Indian J Exp Biol. 2008;46(8):583-590.
29. Prakash A, Medhi B, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. Phytother Res. 2008;22(11): 1511-1519.
30. Uhlen M, Oksvold P, Fagerberg L, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 2010;28(12):1248-1250.
31. Al-Waili NS, Boni NS. Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food. 2003;6(2):129-133.
32. Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfram on infammation, nitric oxide, and free radical formation. Dig Surg. 2002;19(4):306-311; discussion 311-312.