Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes

Experimental Dermatology

Volumn 19, Issue 8, 2010, Pages

  Majtan, Juraj ^a   Kumar, Pawan ^b,c   Majtan, Tomas ^a,d   Walls, Andrew ^c   Klaudiny, Jaroslav ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b BLOOD RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d Nutrition Obesity Research Center at the University of Colorado   (United States)

Author keywords

Honey; Keratinocytes; Major royal jelly protein 1; Skin; Wound healing

Indexed keywords

COLLAGEN TYPE 4; CYTOKINE; GELATINASE B; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MESSENGER RNA; ROYAL JELLY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; EPIDERMIS; HONEY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; KERATINOCYTE; LIMULUS LYSATE TEST; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WOUND HEALING;

CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE IV; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; HONEY; HUMANS; INTERLEUKIN-1BETA; KERATINOCYTES; L-LACTATE DEHYDROGENASE; MALE; MATRIX METALLOPROTEINASE 9; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 77954853946     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00994.x     Document Type: Article

References (37)

1. Singer A J, Clark R A. Cutaneous wound healing. N Engl J Med 1999, 341:738-746.
2. Salo T, Mäkelä M, Kylmäniemi M, Autio-Harmainen H, Larjava H. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab Invest 1994, 70:176-182.
3. Woessner J F. MMPs and TIMPs - an historical perspective. Mol Biotechnol 2002, 22:33-49.
4. Brauchle M, Angermeyer K, Hubner G, Werner S. Large induction of keratinocytes growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 1994, 9:3199-3204.
5. Kristensen M, Chu C, Eedy D, Feldmann M, Brennan F, Breathnach S. Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55 kD but not the 75 kD TNF receptor. Clin Exp Immunol 1993, 94:354-362.
6. Molan P C. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 2006, 5:40-54.
7. Jull A, Rodgers A, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008, 4:1-50. Art. No. CD005083
8. Tonks A J, Cooper R A, Jones K P, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine 2003, 21:242-247.
9. Tonks A J, Dudley E, Porter N G. A 5.8 kDa component of manuka honey stimulates immune cells via TLR4. J Leukocyte Biol 2007, 82:1147-1155.
10. Majtan J, Kovacova E, Bilikova K, Simuth J. The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on TNFα release. Int Immunopharmacol 2006, 6:269-278.
11. Schmitzová J, Klaudiny J, Albert S. A family of major royal jelly proteins of the honeybee Apis mellifera L. Cell Mol Life Sci 1998, 54:1020-1030.
12. Šimúth J, Bíliková K, Kováčová E, Kuzmová Z, Schroder W. Immunochemical approach to detection of adulteration in honey: physiologically active royal jelly protein stimulating TNF-alpha is a regular component of honey. J Agric Food Chem 2004, 52:2154-2158.
13. Kamakura M, Suenobu N, Fukushima M. Fifty-seven-kDa protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum. Biochem Biophys Res Commun 2001, 282:865-874.
14. Matsui T, Yukiyoshi A, Doi S, Sugimoto H, Yamada H, Matsumoto K. Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J Nutr Biochem 2002, 13:80-86.
15. Fontana R, Mendes M A, Monson B D S, Konno K, César L M M, Malaspina O. Jelleines: a family of antimicrobial peptides from the royal jelly of honeybees (Apis mellifera). Peptides 2004, 25:919-928.
16. Fukuda M, Kobayashi K, Hirono Y. Jungle Honey Enhances Immune Function and Antitumor Activity. eCAM 2009, 10.1093/ecam/nen1086, doi
17. Timm M, Bartelt S, Hansen E W. Immunomodulatory effects of honey cannot be distinguished from endotoxin. Cytokine 2008, 42:113-120.
18. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing of protein-dye binding. Anal Biochem 1976, 72:248-254.
19. Oxholm A, Diamant M, Oxholm P, Bendtzen K. Interleukin-6 and tumour necrosis factor alpha are expressed by keratinocytes but not by Langerhans cells. APMIS 1991, 99:58-64.
20. McKay I A, Leigh I M. Epidermal cytokines and their roles in cutaneous wound healing. Br J Dermatol 1991, 124:513-518.
21. Moulin V. Growth factors in skin wound healing. Eur J Cell Biol 1995, 68:1-7.
22. Cooper R A, Molan P C, Harding K G. The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol 2002, 93:857-863.
23. Baroni M V, Chiabrando G A, Costa C, Wunderlin D. Assessment of the floral origin of honey by SDS-page immunoblot techniques. J Agric Food Chem 2002, 50:1262-1267.
24. Lee D C, Lee S Y, Cha S H, Choi Y S, Rhee H I. Discrimination of native bee-honey by and foreign bee-honey by SDS-PAGE. Korean J Food Sci 1998, 30:1-5.
25. Šimúth J. Some properties of the main protein of honeybee (Apis meliffera) royal jelly. Apidologie 2001, 32:69-80.
26. Kimura M, Kimura Y, Tsumura K, Okihara K, Sugimoto H, Yamada H. 350-kDa royal jelly glycoprotein (apisin), which stimulates proliferation of human monocytes, bears the beta1-3 galactosylated N-glycan: analysis of the N-glycosylation site. Biosci Biotechnol Biochem 2003, 67:2055-2058.
27. Tamura S, Kono T, Harada C, Yamaguchi K, Moriyama T. Estimation and characterisation of major royal jelly proteins obtained from the honeybee Apis meliffera. Food Chem 2009, 114:1491-1497.
28. Lebre M C, Aar A M C D, Baarsen L V. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2007, 127:331-341.
29. Song P I, Park Y M, Abraham T. Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 2002, 30:424-432.
30. Kawai K, Shimura H, Minagawa M, Ito A, Tomiyama K, Ito M. Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J Dermatol Sci 2002, 30:185-194.
31. Loryman C, Mansbridge J. Inhibition of keratinocyte migration by lipopolysaccharide. Wound Repair Regen 2008, 16:45-51.
32. Gupta S, Singh H, Varshney A, Prakash P. Therapeutic efficacy of honey in infected wounds in buffaloes. Indian J Anim Res 1992, 62:521-523.
33. Bergman A, Yanai J, Weiss J, Bell D, David M P. Acceleration of wound healing by topical application of honey. An animal model. Am J Surg 1983, 145:374-376.
34. McCawley L J, Matrisian L M. Metrix metalloproteinases: they're not just for matrix anymore!. Curr Opin Cell Biol 2001, 13:534-540.
35. Templin C, Grote K, Schledzewski K. Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms. Exp Dermatol 2009, 18:445-453.
36. Stoff A, Rivera A A, Banerjee N S. Promotion of incisional wound repair by human mesenchymal stem cell transplantation. Exp Dermatol 2009, 18:362-369.
37. Lorenz K, Sicker M, Schmelzer E. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol 2008, 17:925-932.