Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats

Phytotherapy Research

Volumn 22, Issue 11, 2008, Pages 1511-1519

  Prakash, A ^a   Medhi, B ^a   Avti, P K ^a   Saikia, U N ^a   Pandhi, P ^a   Khanduja, K L ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Antioxidant defence system; Colitis; Inflammatory bowel disease; Manuka honey

Indexed keywords

CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MYELOPEROXIDASE; PLANT EXTRACT; SALAZOSULFAPYRIDINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENTERITIS; ENZYME ASSAY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; HONEY; LEPTOSPERMUM; LIPID PEROXIDATION; MALE; MANUKA HONEY; NONHUMAN; PARAMETER; PROTECTION; RAT; TISSUE HOMOGENATE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; COLITIS; COLON; DISEASE MODELS, ANIMAL; GLUTATHIONE; HONEY; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; LIPID PEROXIDATION; MALE; PEROXIDASE; RATS; RATS, WISTAR; SULFASALAZINE; SUPEROXIDE DISMUTASE; TRINITROBENZENESULFONIC ACID;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 57349130063     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2523     Document Type: Article

References (47)

1. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IkB synthesis. Science 270: 286-290.
2. Azim MK, Perveen H, Mesaik MA, Simjee SU. 2007. Antinociceptive activity of natural honey in thermal-nociception models in mice. Phytother Res 21: 194-197.
3. Bilsel Y, Bugra D, Yamaner S, Bulut Y, Cevikbas U, Turkoglu U. 2002. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg 19(4): 306-311.
4. Bora U, Sahu A, Saikia AP, Ryakala VK, Goswami P. 2007. Medicinal plants used by the people of Northeast India for curing malaria. Phytother Res 21: 800-804.
5. Djordjevic A, Spasic S, Jovanovic-Galovic A, Djordjevic R, Grubor-Lajsic G. 2004. Oxidative stress in diabetic pregnancy: SOD, CAT and GSH-Px activity and lipid peroxidation products. J Matern Fetal Neonatal Med 16(6): 367-372.
6. D'Odorico A, Bortolan S, Cardin R et al. 2001. Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 136: 1289-1294.
7. Grant CM, MacIver FH, Dawes IW. 1996. Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast saccharomyces cerevisiae. Curr Genet 29(6): 511-515.
8. Grisham MB, Volkmer C, Tso P, Yamada T. 1991. Metabolism of trinitrobenzenesulfonic acid by the rat colon produces reactive oxygen species. Gastroenterology 101: 540-547.
9. Han SN, Meydani SN. 2000. Antioxidants, cytokines, and influenza infection in aged mice and elderly humans. J Infect Dis 182(suppl 1): S74-S80.
10. Hassan HM, Fridovich I. 1978. Regulation and role of superoxide dismutase. Biochem Soc Trans 6: 356-361.
11. Hermanowicz A, Gibson PR, Jewell DP. 1985. The role of phagocytes in inflammatory bowel disease. Clin Sci 69: 241-259.
12. Joshi R, Kumar S, Unnikrishnan M, Mukherjee T. 2005. Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity. Free Radic Res 39: 1163-1172.
13. Karayalcin SS, Sturbaum W, Wachsman JT, Cha JH, Powell DW. 1990. Hydrogen peroxide stimulates rat colonic prostaglandin production and alters electrolyte transport. J Clin Invest 86: 60-68.
14. Kono Y. 1978. Generation of superoxide radical during autooxidation of hydroxylamine and assay for SOD. Arch Biochem Biophys 186: 189-195.
15. Krawiesz JE, Sharan P, Stenson WF. 1984. Quantitative assay to acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster model. Gastroenterology 87: 1344-1350.
16. Kruidenier L, Verspaget HW. 1998. Antioxidants and mucosa protectives: realistic therapeutic options in inflammatory bowel disease? Mediators Inflamm 7: 157-162.
17. Kunin S, Gallily R. 1983. Recognition and lysis of altered self-cells by macrophages, a modification of target cells by 2, 4, 6-trinitrobenzenesulfonic acid. Immunology 48: 265-272.
18. Kurutas EB, Cetinkaya A, Bulbuloglu E, Kantarceken B. 2005. Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis. Mediators Inflamm 6: 390-394.
19. Larrick JW, Wright SC. 1990. Cytotoxic mechanism of tumor necrosis factor-α. FASEB J 4: 3215-3223.
20. Levine A, Kenet G, Bruk R et al. 2002. Effect of heparin on tissue binding activity of fibroblast growth factor and heparin binding epidermal growth factor in experimental colitis in rats. Pediatric Res 51: 635-640.
21. Loquercio C, D'Argenio G, Delle Cave M et al. 1996. Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats. Dig Dis Sci 41: 1204-1211.
22. Luck H. 1963. Catalase. In Methods of Enzymatic Analysis, Bergmeyer HW (ed.). Academic Press: New York, Section 3, 885-894.
23. Lusby PE, Coombes AL, Wilkinson JM. 2006. A comparison of wound healing following treatment with Lavandula × allardii honey or essential oil. Phytother Res 20: 755-757.
24. Mahgoub AA, el-Medany Ah, Hagar HH, Sabah DM. 2002. Protective effect of natural honey against acetic acid-induced colitis in rats. Trop Gastroenterol 23(2): 82-87.
25. Mårtensson J, Jain A, Stole E, Frayer W, Auld PA, Meister A. 1991. Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci USA 88(20): 9360-9364.
26. Meister A, Anderson ME. 1983. Glutathione. Annu Rev Biochem 52: 711-760.
27. Miranda A, Janssen L, Bosman CB et al. 2000. Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer. Clin Cancer Res 6: 3183-3192.
28. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. 1989. Heptan induced model of chronic inflammation and ulceration in rat colon. Gastroenterology 96: 795.
29. Mulder TP, Verspaget HW, Janssens AR, de Bruin PA, Pena AS, Lamers CB. 1991. Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease. Gut 32: 1146-1150.
30. Murata Y, Ishiguro Y, Itoh J, Munakata A, Yoshida Y. 1995. The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis. J Gastroenterol 30(suppl 8): 56-60.
31. Mythilypriya R, Shanthi P, Sachdanandam P. 2007. Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation - Kalpaamruthaa. Phytother Res 21: 574-578.
32. Nieto N, Fernandez MI, Torres MI, Rios A, Suarez MD, Gil A. 1998a. Dietary n-3 and n-6 long-chain polyunsaturated fatty acids affect cellular antioxidant defense system in rats with experimental ulcerative colitis induced by trinitrobenzene-sulfonic acid. Dig Dis Sci 43: 2676-2687.
33. Nieto N, Giron MD, Suarez MD, Gil A. 1998b. Changes in plasma and colonic mucosa fatty acid profiles in rats with ulcerative colitis induced by trinitrobenzenesulfonic acid. Dig Dis Sci 43: 2688-2695.
34. Nieto N, Torres MI, Fernandez MI et al. 2000. Experimental ulcerative colitis impairs antioxidant defense system in rat intestine. Dig Dis Sci 45: 1820-1827.
35. Ohkawa H, Ohishi N, Yoge K. 1978. Assay of lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biol Chem 95: 351-358.
36. Oz HS, Chen TS, McClain CJ, de Villiers WJ. 2005. Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem 16: 297-304.
37. Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 701: 158-169.
38. Schumbert R, Towner J, Zipser RD. 1989. Role of eicosanoids in human and experimental colitis. Dig Dis Sci 33: 58S-64S.
39. Sedor JR. 1986. Free radicals and prostanoid synthesis (editorial). Lab Clin Med 108: 521-522.
40. Slater TF. 1984. Free-radical mechanisms in tissue injury. Biochem J 222: 1-4.
41. The HS, Phillips RA, Miller RG. 1978. Quantitative studies on the precursors of cytotoxic lymphocytes. The cellular basis of the cross reactivity of TNP-specific clones. J Immunol 121: 1711-1718.
42. Verspaget HW, Mulder TP, Van der Sluys Veer A, Pena A, Lamers CB. 1991. Reactive oxygen metabolites and colitis: a disturbed balance between damage and protection. A selective review. Scand J Gastroenterol Suppl 188: 44-51.
43. Vogel HG, Goethe JW. 2002. Experimental colitis. In Drug Discovery and Evaluation Pharmacological Assay, 2nd edn. Springer: Berlin, 896-899.
44. Wallace JL, McKnight W, Asfaha S, Lio DY. 1998. Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation. Am J Physiol 274: G802-G808.
45. Wendland BE, Aghdassi E, Tarn C et al. 2001. Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. Am J Clin Nutr 74: 259-264.
46. Weston RJ, Mitchell KR, Allen KL. 1999. Antibacterial phenolic components of Manuka Honey. Food Chem 64: 295-301.
47. Zea-lriarte WL, Makiyama K, Goto S et al. 1996. Impairment of antioxidants in colonic epithelial cells isolated from trinitrobenzene sulphonic acid-induced colitis rats. Scand J Gastroenterol 31: 985-992.