Metal ions in the context of nanoparticles toward biological applications

Current Opinion in Chemical Engineering

Volumn 4, Issue , 2014, Pages 88-96

  Carrillo Carrión, Carolina ^a   Nazarenus, Moritz ^a   Paradinas, Sara Sánchez ^a,b   Carregal Romero, Susana ^a   Almendral, María Jesús ^b   Fuentes, Manuel ^b   Pelaz, Beatriz ^a   Del Pino, Pablo ^a,c   Hussain, Irshad ^d   Clift, Martin J D ^e   Rothen Rutishauser, Barbara ^e   Liang, Xing Jie ^f,g   Parak, Wolfgang J ^a,c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c CIC BIOMAGUNE   (Spain)

^d LAHORE UNIVERSITY OF MANAGEMENT SCIENCES   (Pakistan)

^e UNIVERSITY OF FRIBOURG   (Switzerland)

^f NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^g INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL APPLICATIONS; BIOLOGICAL MEDIA; COLLOIDAL NANOPARTICLES; IMAGING APPLICATIONS; INORGANIC NANOPARTICLE;

MAGNETIC RESONANCE IMAGING; NANOPARTICLES;

METAL IONS;

EID: 84897604696     PISSN: None     EISSN: 22113398     Source Type: Journal    
DOI: 10.1016/j.coche.2013.11.006     Document Type: Review

References (110)

1. M. Chanana, P. Rivera-Gil, M.A. Correa-Duarte, W.J. Parak, and L.M. Liz-Marzán Physicochemical properties of protein-coated gold nanoparticles in biological fluids and cells before and after proteolytic digestion Angew Chem Int Ed Engl 52 2013 4179 4183
2. E.C. Dreaden, A.M. Alkilany, X. Huang, C.J. Murphy, and M.A. El-Sayed The golden age: gold nanoparticles for biomedicine Chem Soc Rev 41 2012 2740 2779
3. E. Boisselier, and D. Astruc Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity Chem Soc Rev 38 2009 1759 1782
4. J. Yang, H. Yin, J. Jia, and Y. Wei Facile synthesis of high-concentration. Stable aqueous dispersions of uniform silver nanoparticles using aniline as a reductant Langmuir 27 2011 5047 5053
5. P. Podsiadlo, S. Paternel, J.-M. Rouillard, Z. Zhang, J. Lee, J.-W. Lee, E. Gulari, and N.A. Kotov Layer-by-layer assembly of nacre-like nanostructured composites with antimicrobial properties Langmuir 21 2005 11915 11921 (Pubitemid 43011536)
6. A. Ramakrishnan, K. Dumbuya, J. Ofili, H.P. Steinruck, J.M. Gottfried, and W. Schwieger Highly dispersed Pd nanoparticles within silica: synthesis and characterization Appl Clay Sci 51 2011 8 14
7. D. Ung, L.D. Tung, G. Caruntu, D. Delaportas, I. Alexandrou, I.A. Prior, and N.T.K. Thanh Variant shape growth of nanoparticles of metallic FePt, FePd and FePtPd alloys Cryst Eng Comm 11 2009 1309 1316
8. L.T. Lu, L.D. Tung, I. Robinson, D. Ung, B. Tan, J. Long, A.I. Cooper, D.G. Fernig, and N.T.K. Thanh Size and shape control for water-soluble magnetic cobalt nanoparticles using polymer ligands J Mater Chem 18 2008 2453 2458 (Pubitemid 351671686)
9. Y. Bao, M. Beerman, and K.M. Krishnan Controlled self-assembly of colloidal cobalt nanocrystals J Magn Magn Mater 266 2003 L245 L249
10. 3 nanocrystals Chem Mater 14 2002 1048 1052
11. 3 nanoparticles Polyhedron 33 2012 145 149
12. 2 core shell particles] J Magn Magn Mater 252 2002 4 6
13. J. Drbohlavova, V. Adam, R. Kizek, and J. Hubalek Quantum dots - characterization. Preparation and usage in biological systems Int J Mol Sci 10 2009 656 673
14. A.P. Alivisatos, W.W. Gu, and C. Larabell Quantum dots as cellular probes Annu Rev Biomed Eng 7 2005 55 76 (Pubitemid 41170185)
15. A.L. Rogach, A. Eychmüller, S.G. Hickey, and S.V. Kershaw Infrared-emitting colloidal nanocrystals: synthesis, assembly spectroscopy, and applications Small 3 2007 536 557 (Pubitemid 46624611)
16. W.J. Parak, D. Gerion, T. Pellegrino, D. Zanchet, C. Micheel, S.C. Williams, R. Boudreau, M.A. Le Gros, C.A. Larabell, and A.P. Alivisatos Biological applications of colloidal nanocrystals Nanotechnology 14 2003 R15 R27
17. H.-C. Yeh, J. Sharma, J.J. Han, J.S. Martinez, and J.H. Werner A DNA-silver nanocluster probe that fluoresces upon hybridization Nano Lett 10 2010 3106 3110
18. C.A. Lin, T.Y. Yang, C.H. Lee, S.H. Huang, R.A. Sperling, M. Zanella, J.K. Li, J.L. Shen, H.H. Wang, H.I. Yeh, W.J. Parak, and W.H. Chang Synthesis, characterization, and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications ACS Nano 3 2009 395 401
19. L. Shang, N. Azadfar, F. Stockmar, W. Send, V. Trouillet, M. Bruns, D. Gerthsen, and G.U. Nienhaus One-pot synthesis of near-infrared fluorescent gold clusters for cellular fluorescence lifetime imaging Small 7 2011 2614 2620
20. L. Shang, R.M. Dorlich, V. Trouillet, M. Bruns, and G.U. Nienhaus Ultrasmall fluorescent silver nanoclusters: protein adsorption and its effects on cellular responses Nano Res. 5 2012 531 542
21. S. Huang, C. Pfeiffer, J. Hollmann, S. Friede, J.J.-C. Chen, A. Beyer, K. Volz, W. Heimbrodt, J.M. Montenegro Martos, W. Chang, and W.J. Parak Synthesis and characterization of colloidal fluorescent silver nanoclusters Langmuir 28 2012 8915 8919
22. S. Wilhelm, T. Hirsch, W.M. Patterson, E. Scheucher, T. Mayr, and O.S. Wolfbeis Multicolor upconversion nanoparticles for protein conjugation Theranostics 13 2013 239 248
23. R. Elghanian, J.J. Storhoff, R.C. Mucic, R.L. Letsinger, and C.A. Mirkin Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles Science 277 1997 1078 1081 (Pubitemid 27371624)
24. R.A. Sperling, P. Rivera-Gil, F. Zhang, M. Zanella, and W.J. Parak Biological applications of gold nanoparticles Chem Soc Rev 37 2008 1896 1908
25. 2-xSe nanocrystals Nano Lett 11 2011 4711 4717
26. 2-xSe nanocrystals J Am Chem Soc 133 2011 11175 11180
27. W.H. Li, R. Zamani, P. Rivera-Gil, B. Pelaz, M. Ibanez, D. Cadavid, A. Shavel, R.A. Alvarez-Puebla, W.J. Parak, J. Arbiol, and A. Cabot CuTe nanocrystals: shape and size control, plasmonic properties, and use as SERS probes and photothermal agents J Am Chem Soc 135 2013 7098 7101
28. Q.A. Pankhurst, J. Connolly, S.K. Jones, and J. Dobson Applications of magnetic nanoparticles in biomedicine J Phys D: Appl Phys 36 2003 R167 R181
29. M. Colombo, S. Carregal-Romero, M.F. Casula, L. Gutiérrez, M.P. Morales, I.B. Böhm, J.T. Heverhagen, D. Prosperi, and W.J. Parak Biological applications of magnetic nanoparticles Chem Soc Rev 41 2012 4306 4334
30. P. del Pino, A. Munoz-Javier, D. Vlaskou, P. Rivera Gil, C. Plank, and W.J. Parak Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA Nano Lett 10 2010 3914 3921
31. J.T. Dias, M. Moros, P. del Pino, S. Rivera, V. Grazú, and J.M. de la Fuente DNA as a molecular local thermal probe for the analysis of magnetic hyperthermia Angew Chem Int Ed Engl 52 2013 11526 11529
32. B. Hille Ionic Channels of Excitable Membranes 2nd ed. 1992 Sinauer Associates Inc. Sunderland, MA
33. S. Kittler, C. Greulich, J. Diendorf, M. Koller, and M. Epple Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions Chem Mater 22 2010 4548 4554
34. S. Chernousova, and M. Epple Silver as antibacterial agent: ion, nanoparticle, and metal Angew Chem Int Ed Engl 52 2013 1636 1653
35. A.M. Derfus, W.C.W. Chan, and S.N. Bhatia Probing the cytotoxicity of semiconductor quantum dots Nano Lett 4 2004 11 18 (Pubitemid 38167855)
36. T.G. Iversen, T. Skotland, and K. Sandvig Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies Nano Today 6 2011 176 185
37. F. Zhao, Y. Zhao, Y. Liu, X. Chang, C. Chen, and Y. Zhao Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials Small 7 2011 1322 1337
38. S.D. Conner, and L.S. Schmid Regulated portals of entry into the cell Nature 422 2003 37 41
39. C. Brandenberger, C. Mühlfeld, Z. Ali, A.-G. Lenz, O. Schmid, W.J. Parak, P. Gehr, and B. Rothen-Rutishauser Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles Small 6 2010 1669 1678
40. E. Caballero-Díaz, C. Pfeiffer, L. Kastl, P. Rivera-Gil, B. Simonet, M. Valcárcel, J. Jiménez-Lamana, F. Laborda, and W.J. Parak The toxicity of silver nanoparticles depends on their uptake by cells and thus on their surface chemistry Part Part Syst Charact 30 2013 1079 1085
41. C. Kirchner, T.L. Kudera, S. Pellegrino, T. Muñoz Javier, A. Gaub, H.E. Stölzle, S. Fertig, and N.W.J. Parak Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles Nano Lett 5 2005 331 338 (Pubitemid 40308295)
42. T.L. Doane, and C. Burda The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy Chem Soc Rev 41 2012 2885 2911
43. W.J. Stark Nanoparticles in biological systems Angew Chem Int Ed 50 2011 1242 1258
44. P. Rivera-Gil, G. Oberdorster, A. Elder, V.F. Puntes, and W.J. Parak Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future ACS Nano 4 2010 5527 5531
45. C. Beer, R. Foldbjerg, Y. Hayashi, D.S. Sutherland, and H. Autrup Toxicity of silver nanoparticles - nanoparticle or silver ion? Toxicol Lett 208 2012 286 292
46. J.H. Priester, P.K. Stoimenov, R.E. Mielke, S.M. Webb, C. Ehrhardt, J.P. Zhang, G.D. Stucky, and P.A. Holden Effects of soluble cadmium salts versus CdSe quantum dots on the growth of planktonic Pseudomonas aeruginosa Environ Sci Technol 43 2009 2589 2594
47. A. Galeone, G. Vecchio, M.A. Malvindi, V. Brunetti, R. Cingolanib, and P.P. Pompa In vivo assessment of CdSe-ZnS quantum dots: coating dependent bioaccumulation and genotoxicity Nanoscale 4 2012 6401 6407
48. F. Herzog, M.J.D. Clift, F. Piccapietra, R. Behra, O. Schmid, A. Petri-Fink, and B. Rothen-Rutishauser Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface Part Fibre Toxicol 10 2013 11
49. D. Stampoulis, S.K. Sinha, and J.C. White Assay-dependent phytotoxicity of nanoparticles to plants Environ Sci Technol 43 2009 9473 9479
50. C. Carlson, S.M. Hussain, A.M. Schrand, L.K. Braydich-Stolle, K.L. Hess, R.L. Jones, and J.J. Schlager Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species J Phys Chem B 112 2008 13608 13619
51. H.Y. Zhang, Z.X. Ji, T. Xia, H. Meng, C. Low-Kam, R. Liu, S. Pokhrel, S.J. Lin, X. Wang, Y.P. Liao, M. Wang, L. Li, R. Rallo, R. Damoiseaux, D. Telesca, L. Mädler, Y. Cohen, J.I. Zink, and A.E. Nel Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation ACS Nano 6 2012 4349 4368
52. S. Sharifi, S. Behzadi, S. Laurent, M. Laird Forrest, P. Stroeve, and M. Mahmoudi Toxicity of nanomaterials Chem Soc Rev 41 2012 2323 2343
53. C.C. Huang, R.S. Aronstam, D.R. Chen, and Y.W. Huang Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles Toxicol In Vitro 24 2010 45 55
54. Y.N. Chang, M.Y. Zhang, L. Xia, J. Zhang, and G.M. Xing The toxic effects and mechanisms of CuO and ZnO nanoparticles Materials 5 2012 2850 2871
55. S. Pokhrel, A.E. Nel, and L. Mädler Custom-designed nanomaterial libraries for testing metal oxide toxicity Acc Chem Res 46 2013 Mar 632 641
56. S. George, S. Pokhrel, T. Xia, B. Gilbert, Z. Ji, M. Schowalter, A. Rosenauer, R. Damoiseaux, K.A. Bradley, L. Mädler, and A.E. Nel Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping ACS Nano 4 2010 15 29
57. T. Xia, Y. Zhao, T. Sager, S. George, S. Pokhrel, N. Li, D. Schoenfeld, H. Meng, S. Lin, X. Wang, M. Wang, Z. Ji, J.I. Zink, L. Mädler, V. Castranova, S. Lin, and A.E. Nel Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos ACS Nano 5 2011 1223 1235
58. S.T. Selvan, T.T. Tan, and J.Y. Ying Robust, non-cytotoxic, silica-coated CdSe quantum dots with efficient photoluminescence Adv Mater 17 2005 1620 1625 (Pubitemid 40963859)
59. M.J. Hajipour, K.M. Fromm, A. Akbar Ashkarran, D. Jimenez de Aberasturi, Larramendi IRd, T. Rojo, V. Serpooshan, W.J. Parak, and M. Mahmoudi Antibacterial properties of nanoparticles Trends Biotechnol 30 2012 499 511
60. R. Behra, L. Sigg, M.J. Clift, F. Herzog, M. Minghetti, B. Johnston, A. Petri-Fink, and B. Rothen-Rutishauser Bioavailability of silver nanoparticles and ions: from a chemical and biochemical J R Soc Interface 10 2013 20130396
61. A.S. Susha, A.M. Javier, W.J. Parak, and A.L. Rogach Luminescent CdTe nanocrystals as ion probes and pH sensors in aqueous solutions Colloid Surf A 281 2006 40 43 (Pubitemid 44255729)
62. S.E. Skrabalak, J. Chen, Y. Sun, X. Lu, L. Au, C.M. Cobley, and Y. Xia Gold Nanocages: synthesis, properties, and applications Acc Chem Res 41 2008 1587 1595
63. M.H. Oh, T. Yu, S.H. Yu, B. Lim, K.T. Ko, M.G. Willinger, D.H. Seo, B.H. Kim, M.G. Cho, J.H. Park, K. Kang, Y.E. Sung, N. Pinna, and T. Hyeon Galvanic replacement reactions in metal oxide nanocrystals Science 340 2013 964 968
64. E. Gonzalez, J. Arbiol, and V.F. Puntes Carving at the nanoscale: sequential galvanic exchange and kirkendall growth at room temperature Science 334 2011 1377 1380
65. D.H. Son, S.M. Hughes, Y. Yin, and A.P. Alivisatos Cation exchange reactions in ionic nanocrystals Science 306 2004 1009 1012 (Pubitemid 39482899)
66. C. Xu, L. Mu, I. Roes, D. Miranda-Nieves, M. Nahrendorf, J.A. Ankrum, W. Zhao, and J.M. Karp Nanoparticle-based monitoring of cell therapy Nanotechnology 22 2011 494001
67. M.F. Warsi Lanthanide Functionalised Gold Nanoparticles as MRI Contrast Agent 2010 The University of York York, UK
68. H.B. Na, I.C. Song, and T. Hyeon Inorganic nanoparticles for MRI contrast agents Adv Mater 21 2009 2133 2148
69. L.A. Tran, R. Krishnamurthy, R. Muthupillai, G. Cabreira-Hansen Mda, J.T. Willerson, E.C. Perin, and L.J. Wilson Gadonanotubes as magnetic nanolabels for stem cell detection Biomaterials 31 2010 9482 9491
70. P. Rivera-Gil, and W.J. Parak Composite nanoparticles take aim at cancer ACS Nano 2 2008 2200 2205
71. H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J Control Release 65 2000 271 284 (Pubitemid 30122932)
72. A.K. Iyer, G. Khaled, J. Fang, and H. Maeda Exploiting the enhanced permeability and retention effect for tumor targeting Drug Discov Today 11 2006 812 818 (Pubitemid 44280021)
73. W.J. Rieter, J.S. Kim, K.M.L. Taylor, H.Y. An, W.L. Lin, T. Tarrant, and W.B. Lin Hybrid silica nanoparticles for multimodal Imaging Angew Chem Int Ed 46 2007 3680 3682 (Pubitemid 46981247)
74. J.K. Hsiao, C.P. Tsai, T.H. Chung, Y. Hung, M. Yao, H.M. Liu, C.Y. Mou, C.S. Yang, Y.C. Chen, and D.M. Huang Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking Small 4 2008 1445 1452
75. H. Kobayashi, S. Kawamoto, M. Bernardo, M.W. Brechbiel, M.V. Knopp, and P.L. Choyke Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging J Control Release 111 2006 343 351
76. Z.L. Cheng, D.L.J. Thorek, and A. Tsourkas Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T-1 magnetic resonance imaging contrast agent Angew Chem Int Ed 49 2010 346 350
77. W.J.M. Mulder, G.J. Strijkers, G.A.F. van Tilborg, A.W. Griffioen, and K. Nicolay Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging NMR Biomed 19 2006 142 164 (Pubitemid 43250800)
78. T. Bui, J. Stevenson, J. Hoekman, S.R. Zhang, K. Maravilla, and R.J.Y. Ho Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging PLoS One 5 9 2010 e13082
79. P. Tallury, S. Santra, P. Sharma, B.M.D. Matos, N. Bengtsson, S. Biswas, A.K. Saha, G.A. Walter, E.A. Scott, and B.M. Moudgil Fluorescent and paramagnetic chitosan nanoparticles that exhibit high magnetic resonance relaxivity: synthesis, characterization and in vitro studies J Biomed Nanotechnol 7 2011 724 729
80. K.H. Bae, Y.B. Kim, Y. Lee, J. Hwang, H. Park, and T.G. Park Bioinspired synthesis and characterization of gadolinium-labeled magnetite nanoparticles for dual contrast T-1- and T-2-weighted magnetic resonance imaging Bioconjugate Chem 21 2010 505 512
81. H. Yang, Y.M. Zhuang, Y. Sun, A.T. Dai, X.Y. Shi, D.M. Wu, F.Y. Li, H. Hu, and S.P. Yang Targeted dual-contrast T-1- and T-2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles Biomaterials 32 2011 4584 4593
82. Z. Ali, A.Z. Abbasi, F. Zhang, P. Arosio, A. Lascialfari, M.F. Casula, A. Wenk, W. Kreyling, R. Plapper, and M. Seidel et al. Multifunctional nanoparticles for dual imaging Anal Chem 83 2011 2877 2882
83. C. Alric, J. Taleb, G. Le Duc, C. Mandon, C. Billotey, A. Le Meur-Herland, T. Brochard, F. Vocanson, M. Janier, P. Perriat, S. Roux, and O. Tillement Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging J Am Chem Soc 130 2008 5908 5915 (Pubitemid 351620836)
84. M.F. Warsi, R.W. Adams, S.B. Duckett, and V. Chechik Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating Chem Commun 46 2010 451 453
85. L.M. Manus, D.J. Mastarone, E.A. Waters, X.-Q. Zhang, E.A. Schultz-Sikma, K.W. MacRenaris, D. Ho, and T.J. Meade Gd(III)-nanodiamond conjugates for MRI contrast enhancement Nano Lett 10 2010 484 489
86. G. Gopalakrishnan, C. Danelon, P. Izewska, M. Prummer, P.Y. Bolinger, I. Geissbuhler, D. Demurtas, J. Dubochet, and H. Vogel Multifunctional lipid/quantum dot hybrid nanocontainers for controlled targeting of live cells Angew Chem Int Ed 45 2006 5478 5483 (Pubitemid 44384330)
87. 3+-functionalized near-infrared quantum dots for in vivo dual modal (fluorescence/magnetic resonance) imaging Chem Commun 44 2008 5764 5766
88. D. Gerion, J. Herberg, R. Bok, E. Gjersing, E. Ramon, R. Maxwell, J. Kurhanewicz, T.F. Budinger, J.W. Gray, M.A. Shuman, and F.F. Chen Paramagnetic silica-coated nanocrystals as an advanced MRI contrast agent J Phys Chem 111 2007 12542 12551 (Pubitemid 47388081)
89. L. Prinzen, R.J.J.H.M. Miserus, A. Dirksen, T.M. Hackeng, N. Deckers, N.J. Bitsch, R.T.A. Megens, K. Douma, J.W. Heemskerk, M.E. Kooi, P.M. Frederik, D.W. Slaaf, M.A. van Zandvoort, and C.P. Reutelingsperger Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots Nano Lett 7 2007 93 100 (Pubitemid 46225835)
90. F. Erogbogbo, C.-W. Chang, J.L. May, L. Liu, R. Kumar, W.-C. Law, H. Ding, K.T. Yong, I. Roy, M. Sheshadri, M.T. Swihart, and P.N. Prasad Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications Nanoscale 4 2012 5483 5489
91. L.J. Charbonniere, and N. Hildebrandt Lanthanide complexes and quantum dots: a bright wedding for resonance energy transfer Eur J Inorg Chem 21 2008 3241 3251
92. D. Jimenez de Aberasturi, J.M. Montenegro, I. Ruiz de Larramendi, T. Rojo, T.A. Klar, R. Alvarez-Puebla, L.M. Liz-Marzán, and W.J. Parak Optical sensing of small ions with colloidal nanoparticles Chem Mater 24 2012 738 745
93. F. Zhang, Z. Ali, F. Amin, A. Feltz, M. Oheim, and W.J. Parak Ion and pH sensing with colloidal nanoparticles: influence of surface charge on sensing and colloidal properties Chem Phys Chem 11 2010 730 735
94. A. Riedinger, F. Zhang, F. Dommershausen, C. Röcker, S. Brandholt, G.U. Nienhaus, U. Koert, and W.J. Parak Ratiometric optical sensing of chloride ions with organic fluorophore - gold nanoparticle hybrids: a systematic study of distance dependency and the influence of surface charge Small 6 2010 2590 2597
95. F. Zhang, E. Lees, F. Amin, P. Rivera-Gil, F. Yang, P. Mulvaney, and W.J. Parak Polymer-coated nanoparticles: a universal tool for biolabelling experiments Small 7 2011 3113 3127
96. Y.W. Lin, C.C. Huang, and H.T. Chang Gold nanoparticle probes for the detection of mercury, lead and copper ions Analyst 136 2011 863 871
97. Y.J. Kim, R.C. Johnson, and J.T. Hupp Gold nanoparticle-based sensing of "spectroscopically silent" heavy metal ions Nano Lett 1 2001 165 167
98. C.C. Huang, Z. Yang, K.H. Lee, and H.T. Chang Synthesis of highly fluorescent gold nanoparticles for sensing Mercury(II) Angew Chem Int Ed 46 2007 6824 6828 (Pubitemid 47425796)
99. Y.F. Chen, and Z. Rosenzweig Luminescent CdS quantum dots as selective ion probes Anal Chem 74 2002 5132 5138
100. M.T. Fernandez-Argüelles, W.J. Jin, J.M. Costa-Fernandez, R. Pereiro, and A. Sanz-Medel Surface-modified CdSe quantum dots for the sensitive and selective determination of Cu(II) in aqueous solutions by luminescent measurements Anal Chim Acta 549 2005 20 25 (Pubitemid 41160506)
101. + ions by nucleic acid functionalized CdSe/ZnS quantum dots and their use for logic gate operations Angew Chem Int Ed 48 2009 7818 7821
102. H.A. Clark, S.L.R. Barker, M. Brasuel, M.T. Miller, E. Monson, S. Parus, Z.Y. Shi, A. Song, B. Thorsrud, R. Kopelman, A. Ade, W. Meixner, B. Athey, M. Hoyer, D. Hill, R. Lightle, and M.A. Philbert Subcellular optochemical nanobiosensors: probes encapsulated by biologically localised embedding (PEBBLEs) Sens Actuators B: Chem 51 1998 12 16 (Pubitemid 128433355)
103. E.J. Park, M. Brasuel, C. Behrend, M.A. Philbert, and R. Kopelman Ratiometric optical PEBBLE nanosensors for real-time magnesium ion concentrations inside viable cells Anal Chem 75 2003 3784 3791 (Pubitemid 36962112)
104. H.A. Clark, M. Hoyer, M.A. Philbert, and R. Kopelman Optical nanosensors for chemical analysis inside single living cells. 1. Fabrication. Characterization, and methods for intracellular delivery of PEBBLE sensors Anal Chem 71 1999 4831 4836
105. J. Sumner, J.W. Aylott, E. Monson, and R. Kopelman A fluorescent PEBBLE nanosensor for intracellular free zinc Analyst 127 2002 11 16 (Pubitemid 34081624)
106. 2+-sensitive PEBBLE fluorescent nanosensors using DsRed as the recognition element Sens Actuators B: Chem 113 2006 760 767 (Pubitemid 43184119)
107. J.P. Sumner, and R. Kopelman Alexa Fluor 488 as an iron sensing molecule and its application in PEBBLE nanosensors Analyst 130 2005 528 533 (Pubitemid 40523252)
108. M. Brasuel, R. Kopelman, I. Kasman, T.J. Miller, and M.A. Philbert Ion concentrations in live cells from highly selective ion correlation fluorescent nano-sensors for sodium Proc IEEE Sensors 1 2002 288 292
109. M. Brasuel, R. Kopelman, J.W. Aylott, H. Clark, H. Xu, M. Hoyer, T.J. Miller, R. Tjalkens, and M.A. Philbert Production, characteristics and applications of fluorescent PEBBLE nanosensors: potassium, oxygen, calcium and pH imaging inside live cells Sens Mater 14 2002 309 338
110. D. Si, T. Epstein, Lee Y-EK, and R. Kopelman Nanoparticle PEBBLE sensors for quantitative nanomolar imaging of intracellular free calcium ions Anal Chem 84 2012 978 986