Differential effects of nitrostyrene derivatives on myelopoiesis involve regulation of C/EBPα and p38MAPK activity

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Bartels, Marije ^a   Calgarotto, Andrana K ^b   Martens, Anton C ^a   Maso, Victor ^b   Da Silva, Saulo L ^c   Bierings, Marc B ^a   De Souza Queiroz, Mary L ^b   Coffer, Paul J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1 NITRO 3 (2 NITROVINYL)BENZENE; CCAAT ENHANCER BINDING PROTEIN ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITROSTYRENE 1 (2 NITROVINYL)BENZENE; STYRENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL EXPANSION; CELL LINEAGE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE; MALE; MOUSE; MYELOID PROGENITOR CELL; MYELOPOIESIS; NEUTROPHIL; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CFU COUNTING; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; STEM CELL;

ANIMALS; BONE MARROW CELLS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; MACROPHAGES; MALE; MICE, INBRED BALB C; MYELOPOIESIS; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; STEM CELLS; STYRENES;

EID: 84897556371     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090586     Document Type: Article

References (30)

1. Berliner N (2008) Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis. Blood 111(12):5427-5432.
2. Cantor AB, Orkin SH (2001) Hematopoietic development: a balancing act. Curr Opin Genet Dev 11(5):513-519. (Pubitemid 32800724)
3. Enver T, Heyworth CM, Dexter TM (1998) Do stem cells play dice? Blood 92(2):348-351.
4. Metcalf D (1998) Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation. Blood 92(2):345-347.
5. Friedman AD (2002) Transcriptional regulation of granulocyte and monocyte development. Oncogene 21(21):3377-3390.
6. Friedman AD (2002) Transcriptional regulation of myelopoiesis. Int J Hematol 75(5):466-472.
7. Ward AC, Loeb DM, Soede-Bobok AA, Touw IP, Friedman AD (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14(6):973-990. (Pubitemid 30389501)
8. Geest CR, Coffer PJ (2009) MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol 86(2):237-250.
9. Arthur JSC, Ley SC (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13:679-692.
10. Fathi AR, Krautheim A, Kaap S, Eger K, Steinfelder HJ (2000) Michael adducts of ascorbic acid as inhibitors of protein phosphatase 2A and inducers of apoptosis. Bioorg Med Chem Lett 10(14):1605-1608. (Pubitemid 30449731)
11. Kaap S, Quentin I, Tamiru D, Shaheen M, Eger K, et al. (2003) Structure activity analysis of the pro-apoptotic, antitumor effect of nitrostyrene adducts and related compounds. Biochem Pharmacol 65(4):603-610. (Pubitemid 36144246)
12. Kim JH, Kim JH, Lee GE, Lee JE, Chung IK (2003) Potent inhibition of human telomerase by nitrostyrene derivatives. Mol Pharmacol 63(5):1117-1124. (Pubitemid 36529930)
13. Villar JA, Lima FT, Veber CL, Oliveira AR, Calgarotto AK, et al. (2008) Synthesis and evaluation of nitrostyrene derivative compounds, new snake venom phospholipase A2 inhibitors. Toxicon 51(8):1467-1478.
14. Park J, Pei D (2004) trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases. Biochemistry 43(47):15014-15021. (Pubitemid 39587478)
15. Wang WY, Hsieh PW, Wu YC, Wu CC (2007) Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem Pharmacol 74(4):601-611.
16. Fecchio D, Sirois P, Russo M, Jancar S (1990) Studies on inflammatory response induced by Ehrlich tumor in mice peritoneal cavity. Inflammation 14(1):125-132. (Pubitemid 20061425)
17. Rich IN (1991) The effect of 5-fluorouracil on eryhtropoiesis. Blood 77(6):1164-1170.
18. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, et al. (2004) Phosphorylation of C/EBP inhibits granulopoiesis. Mol Cell Biol 24(2):675-686.
19. Dahl R, Walsh JC, Lancki D, Laslo P, Iyer SR, et al. (2003) Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol 4(10):1029-1036. (Pubitemid 37265925)
20. Friedman AD, Keefer JR, Kummalue T, Liu H, Wang QF, et al. (2003) Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha. Blood Cells Mol Dis 31(3):338-341. (Pubitemid 37433874)
21. Wang D, D'Costa J, Civin CI, Friedman AD (2006) C/EBPalpha directs monocytic commitment of primary myeloid progenitors. Blood 108(4):1223-1229. (Pubitemid 44232018)
22. Katsoulidis E, Li Y, Yoon P, Sassano A, Altman J, et al. (2005) Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res 65(19):9029-9037. (Pubitemid 41377395)
23. Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, et al. (2006) Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 108(13):4170-4177. (Pubitemid 44913289)
24. Verma A, Deb DK, Sassano A, Uddin S, Varga J, et al. (2002) Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem 277(10):7726-7735. (Pubitemid 34968219)
25. Spinelli E, Caporale R, Buchi F, Masala E, Gozzini A, et al. (2012) Distinct signal transduction abnormalities and erythropoietin response in bone marrow hematopoietic cell subpopulations of myelodysplastic syndrome patients. Clin Cancer Res 18(11):3079-3089.
26. Schonthal AH (2001) Role of serine/threonine protein phosphatase 2A in cancer. Cancer Lett 170(1):1-13.
27. Peng A, Maller JL (2010) Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene 29(45):5977-5988.
28. Alvarado-Kristensson M, Andersson T (2005) Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3. J Biol Chem 280(7):6238-6244. (Pubitemid 40280109)
29. Lin SP, Lee YT, Wang JY, Miller SA, Chiou SH, et al. (2012) Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS One 7(11):e49605.
30. Prickett TD, Brautigan DL (2007) Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol 27(12):4217-4227. (Pubitemid 46906547)