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Volumn 27, Issue 12, 2007, Pages 4217-4227

Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; AMINO ACID; ANISOMYCIN; CASPASE 3; CASPASE 7; HEMAGGLUTININ; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; NOCODAZOLE; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; SMALL INTERFERING RNA; SORBITOL; STRESS ACTIVATED PROTEIN KINASE; THREONINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 34250209867     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00067-07     Document Type: Article
Times cited : (48)

References (55)
  • 1
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal, B. B. 2003. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3:745-756.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 2
    • 33750611276 scopus 로고    scopus 로고
    • The case for survivin as a regulator of microtubule dynamics and cell-death decisions
    • Altieri, D. C. 2006. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr. Opin. Cell Biol. 18:609-615.
    • (2006) Curr. Opin. Cell Biol , vol.18 , pp. 609-615
    • Altieri, D.C.1
  • 3
    • 0037175021 scopus 로고    scopus 로고
    • A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils
    • Avdi, N. J., K. C. Malcolm, J. A. Nick, and G. S. Worthen. 2002. A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils. J. Biol. Chem. 277:40687-40696.
    • (2002) J. Biol. Chem , vol.277 , pp. 40687-40696
    • Avdi, N.J.1    Malcolm, K.C.2    Nick, J.A.3    Worthen, G.S.4
  • 4
    • 33845501864 scopus 로고    scopus 로고
    • Apoptosome: A platform for the activation of initiator caspases
    • Bao, Q., and Y. Shi. 2006. Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ. 14:56-65.
    • (2006) Cell Death Differ , vol.14 , pp. 56-65
    • Bao, Q.1    Shi, Y.2
  • 5
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck, T., and M. N. Hall. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-692.
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 6
    • 33748747786 scopus 로고    scopus 로고
    • p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65
    • Cai, B., S. H. Chang, E. B. Becker, A. Bonni, and Z. Xia. 2006. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J. Biol. Chem. 281:25215-25222.
    • (2006) J. Biol. Chem , vol.281 , pp. 25215-25222
    • Cai, B.1    Chang, S.H.2    Becker, E.B.3    Bonni, A.4    Xia, Z.5
  • 9
    • 8544253279 scopus 로고    scopus 로고
    • p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs
    • Cheung, P. Y., Y. Zhang, J. Long, S. Lin, M. Zhang, Y. Jiang, and Z. Wu. 2004. p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. J. Biol. Chem. 279:45308-45311.
    • (2004) J. Biol. Chem , vol.279 , pp. 45308-45311
    • Cheung, P.Y.1    Zhang, Y.2    Long, J.3    Lin, S.4    Zhang, M.5    Jiang, Y.6    Wu, Z.7
  • 10
    • 0033543158 scopus 로고    scopus 로고
    • Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2
    • Chung, H., A. C. Nairn, K. Murata, and D. L. Brautigan. 1999. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry 38:10371-10376.
    • (1999) Biochemistry , vol.38 , pp. 10371-10376
    • Chung, H.1    Nairn, A.C.2    Murata, K.3    Brautigan, D.L.4
  • 12
    • 0029808294 scopus 로고    scopus 로고
    • Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
    • Di Como, C. J., and K. T. Arndt. 1996. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10:1904-1916.
    • (1996) Genes Dev , vol.10 , pp. 1904-1916
    • Di Como, C.J.1    Arndt, K.T.2
  • 13
    • 0033593066 scopus 로고    scopus 로고
    • A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes
    • Eto, M., A. Karginov, and D. L. Brautigan. 1999. A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. Biochemistry 38:16952-16957.
    • (1999) Biochemistry , vol.38 , pp. 16952-16957
    • Eto, M.1    Karginov, A.2    Brautigan, D.L.3
  • 14
    • 2042538029 scopus 로고    scopus 로고
    • Structure and regulation of MAPK phosphatases
    • Farooq, A., and M. M. Zhou. 2004. Structure and regulation of MAPK phosphatases. Cell Signal. 16:769-779.
    • (2004) Cell Signal , vol.16 , pp. 769-779
    • Farooq, A.1    Zhou, M.M.2
  • 15
    • 27644439209 scopus 로고    scopus 로고
    • Anoikis
    • Gilmore, A. P. 2005. Anoikis. Cell Death Differ. 12(Suppl. 2):1473-1477.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1473-1477
    • Gilmore, A.P.1
  • 16
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-74.
    • (1977) J. Gen. Virol , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 17
    • 3242683251 scopus 로고    scopus 로고
    • p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L)
    • Grethe, S., M. P. Ares, T. Andersson, and M. I. Porn-Ares. 2004. p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L). Exp. Cell Res. 298:632-642.
    • (2004) Exp. Cell Res , vol.298 , pp. 632-642
    • Grethe, S.1    Ares, M.P.2    Andersson, T.3    Porn-Ares, M.I.4
  • 18
    • 29044443481 scopus 로고    scopus 로고
    • p38 MAPK regulates phosphorylation of Bad via PP2A-depcndent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis
    • Grethe, S., and M. I. Porn-Ares. 2006. p38 MAPK regulates phosphorylation of Bad via PP2A-depcndent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis. Cell Signal. 18:531-540.
    • (2006) Cell Signal , vol.18 , pp. 531-540
    • Grethe, S.1    Porn-Ares, M.I.2
  • 19
    • 33751309077 scopus 로고    scopus 로고
    • Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D
    • Hui, L., Y. Zheng, Y. Yan, J. Bargonetti, and D. A. Foster. 2006. Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D. Oncogene 25:7305-7310.
    • (2006) Oncogene , vol.25 , pp. 7305-7310
    • Hui, L.1    Zheng, Y.2    Yan, Y.3    Bargonetti, J.4    Foster, D.A.5
  • 20
    • 0033231020 scopus 로고    scopus 로고
    • From receptors to stress-activated MAP kinases
    • Ichijo, H. 1999. From receptors to stress-activated MAP kinases. Oncogene 18:6087-6093.
    • (1999) Oncogene , vol.18 , pp. 6087-6093
    • Ichijo, H.1
  • 21
    • 33645765290 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis
    • Inoue, T., D. L. Boyle, M. Corr, D. Hammaker, R. J. Davis, R. A. Flavell, and G. S. Firestein. 2006. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 103:5484-5489.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 5484-5489
    • Inoue, T.1    Boyle, D.L.2    Corr, M.3    Hammaker, D.4    Davis, R.J.5    Flavell, R.A.6    Firestein, G.S.7
  • 22
    • 15444370901 scopus 로고    scopus 로고
    • Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes
    • Inoue, T., D. Hammaker, D. L. Boyle, and G. S. Firestein. 2005. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J. Immunol. 174:4301-4306.
    • (2005) J. Immunol , vol.174 , pp. 4301-4306
    • Inoue, T.1    Hammaker, D.2    Boyle, D.L.3    Firestein, G.S.4
  • 23
    • 0028901087 scopus 로고
    • Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
    • Inui, S., K. Kuwahara, J. Mizutani, K. Maeda, T. Kawai, H. Nakayasu, and N. Sakaguchi. 1995. Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction. J. Immunol. 154:2714-2723.
    • (1995) J. Immunol , vol.154 , pp. 2714-2723
    • Inui, S.1    Kuwahara, K.2    Mizutani, J.3    Maeda, K.4    Kawai, T.5    Nakayasu, H.6    Sakaguchi, N.7
  • 24
    • 0032528434 scopus 로고    scopus 로고
    • Ig receptor binding protein 1 (α4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
    • Inui, S., H. Sanjo, K. Maeda, H. Yamamoto, E. Miyamoto, and N. Sakaguchi. 1998. Ig receptor binding protein 1 (α4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood 92:539-546.
    • (1998) Blood , vol.92 , pp. 539-546
    • Inui, S.1    Sanjo, H.2    Maeda, K.3    Yamamoto, H.4    Miyamoto, E.5    Sakaguchi, N.6
  • 25
    • 0035930339 scopus 로고    scopus 로고
    • T1P41 interacts with TAP42 and negatively regulates the TOR signaling pathway
    • Jacinto, E., B. Guo, K. T. Arndt, T. Schmelzle, and M. N. Hall. 2001. T1P41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell. 8:1017-1026.
    • (2001) Mol. Cell , vol.8 , pp. 1017-1026
    • Jacinto, E.1    Guo, B.2    Arndt, K.T.3    Schmelzle, T.4    Hall, M.N.5
  • 26
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • Janssens, V., and J. Goris. 2001. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353:417-439.
    • (2001) Biochem. J , vol.353 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 28
    • 0028282096 scopus 로고
    • Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate
    • Kuwahara, K., T. Matsuo, J. Nomura, H. Igarashi, M. Kimoto, S. Inui, and N. Sakaguchi. 1994. Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate. J. Immunol. 152:2742-2752.
    • (1994) J. Immunol , vol.152 , pp. 2742-2752
    • Kuwahara, K.1    Matsuo, T.2    Nomura, J.3    Igarashi, H.4    Kimoto, M.5    Inui, S.6    Sakaguchi, N.7
  • 29
    • 33644524383 scopus 로고    scopus 로고
    • B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene 1EX-1 and ERK
    • Letourneux, C., G. Rocher, and F. Porteu. 2006. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene 1EX-1 and ERK. EMBO J. 25:727-738.
    • (2006) EMBO J , vol.25 , pp. 727-738
    • Letourneux, C.1    Rocher, G.2    Porteu, F.3
  • 30
    • 0035811068 scopus 로고    scopus 로고
    • Phosphorylation and microtubule association of the Opitz syndrome protein Mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4
    • Liu, J., T. D. Prickett, E. Elliott, G. Meroni, and D. L. Brautigan. 2001. Phosphorylation and microtubule association of the Opitz syndrome protein Mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4. Proc. Natl. Acad. Sci. USA 98:6650-6655.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6650-6655
    • Liu, J.1    Prickett, T.D.2    Elliott, E.3    Meroni, G.4    Brautigan, D.L.5
  • 31
    • 33646116320 scopus 로고    scopus 로고
    • Solution structure of the RBCC/TR1M B-box1 domain of human MID1: B-box with a RING
    • Massiah, M. A., B. N. Simmons, K. M. Short, and T. C. Cox. 2006. Solution structure of the RBCC/TR1M B-box1 domain of human MID1: B-box with a RING. J. Mol. Biol. 358:532-545.
    • (2006) J. Mol. Biol , vol.358 , pp. 532-545
    • Massiah, M.A.1    Simmons, B.N.2    Short, K.M.3    Cox, T.C.4
  • 32
    • 33646141371 scopus 로고    scopus 로고
    • The Tgif2 gene contains a retained intron within the coding sequence
    • Melhuish, T. A., and D. Wotton. 2006. The Tgif2 gene contains a retained intron within the coding sequence. BMC Mol. Biol. 7:2.
    • (2006) BMC Mol. Biol , vol.7 , pp. 2
    • Melhuish, T.A.1    Wotton, D.2
  • 33
    • 0027451706 scopus 로고
    • The extracellular matrix as a cell survival factor
    • Meredith, J. E., Jr., B. Fazeli, and M. A. Schwartz. 1993. The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4:953-961.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 953-961
    • Meredith Jr., J.E.1    Fazeli, B.2    Schwartz, M.A.3
  • 34
    • 0000714961 scopus 로고    scopus 로고
    • Regulation of protein kinase cascades by protein phosphatase 2A
    • Millward, T. A., S. Zolnierowcz, and B. A. Hemmings. 1999. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24:186-191.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 186-191
    • Millward, T.A.1    Zolnierowcz, S.2    Hemmings, B.A.3
  • 35
    • 0027143725 scopus 로고
    • Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
    • Mumby, M. C., and G. Walter. 1993. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol. Rev. 73:673-699.
    • (1993) Physiol. Rev , vol.73 , pp. 673-699
    • Mumby, M.C.1    Walter, G.2
  • 36
    • 0030984108 scopus 로고    scopus 로고
    • B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
    • Murata, K., J. Wu, and D. L. Brautigan. 1997. B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc. Natl. Acad. Sci. USA 94:10624-10629.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10624-10629
    • Murata, K.1    Wu, J.2    Brautigan, D.L.3
  • 38
    • 0033033091 scopus 로고    scopus 로고
    • Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases
    • Nanahoshi, M., Y. Tsujishita, C. Tokunaga, S. Inui, N. Sakaguchi, K. Hara, and K. Yonezawa. 1999. Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases. FEBS Lett. 446:108-112.
    • (1999) FEBS Lett , vol.446 , pp. 108-112
    • Nanahoshi, M.1    Tsujishita, Y.2    Tokunaga, C.3    Inui, S.4    Sakaguchi, N.5    Hara, K.6    Yonezawa, K.7
  • 39
    • 10744222950 scopus 로고    scopus 로고
    • Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells
    • Park, M. T., J. A. Choi, M. J. Kim, H. D. Um, S. Bae, C. M. Kang, C. K. Cho, S. Kang, H. Y. Chung, Y. S. Lee, and S. J. Lee. 2003. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J. Biol. Chem. 278:50624- 50634.
    • (2003) J. Biol. Chem , vol.278 , pp. 50624-50634
    • Park, M.T.1    Choi, J.A.2    Kim, M.J.3    Um, H.D.4    Bae, S.5    Kang, C.M.6    Cho, C.K.7    Kang, S.8    Chung, H.Y.9    Lee, Y.S.10    Lee, S.J.11
  • 41
    • 33750076984 scopus 로고    scopus 로고
    • The alpha-4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A
    • Prickett, T. D., and D. L. Brautigan. 2006. The alpha-4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. J. Biol. Chem. 281:30503-30511.
    • (2006) J. Biol. Chem , vol.281 , pp. 30503-30511
    • Prickett, T.D.1    Brautigan, D.L.2
  • 42
    • 4644360207 scopus 로고    scopus 로고
    • Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits
    • Prickett, T. D., and D. L. Brautigan. 2004. Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits. J. Biol. Chem. 279:38912-38920.
    • (2004) J. Biol. Chem , vol.279 , pp. 38912-38920
    • Prickett, T.D.1    Brautigan, D.L.2
  • 43
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux, P. P., and J. Blenis. 2004. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68:320-344.
    • (2004) Microbiol. Mol. Biol. Rev , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 44
    • 6344237317 scopus 로고    scopus 로고
    • PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p
    • Santhanam, A., A. Hartley, K. Duvel, J. R. Broach, and S. Garrett. 2004. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryot. Cell 3:1261-1271.
    • (2004) Eukaryot. Cell , vol.3 , pp. 1261-1271
    • Santhanam, A.1    Hartley, A.2    Duvel, K.3    Broach, J.R.4    Garrett, S.5
  • 45
    • 0037633932 scopus 로고    scopus 로고
    • Schultz, D. R., and W. J. Harrington, Jr. 2003. Apoptosis: programmed cell death at a molecular level. Semin. Arthritis Rheum. 32:345-369.
    • Schultz, D. R., and W. J. Harrington, Jr. 2003. Apoptosis: programmed cell death at a molecular level. Semin. Arthritis Rheum. 32:345-369.
  • 46
    • 33747334635 scopus 로고    scopus 로고
    • Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IκBε
    • Stefansson, B., and D. L. Brautigan. 2006. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IκBε. J. Biol. Chem. 281:22624-22634.
    • (2006) J. Biol. Chem , vol.281 , pp. 22624-22634
    • Stefansson, B.1    Brautigan, D.L.2
  • 47
    • 0036687249 scopus 로고    scopus 로고
    • Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis
    • Tanaka, N., M. Kamanaka, H. Enslen, C. Dong, M. Wysk, R. J. Davis, and R. A. Flavell. 2002. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 3:785-791.
    • (2002) EMBO Rep , vol.3 , pp. 785-791
    • Tanaka, N.1    Kamanaka, M.2    Enslen, H.3    Dong, C.4    Wysk, M.5    Davis, R.J.6    Flavell, R.A.7
  • 49
    • 27744512550 scopus 로고    scopus 로고
    • Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    • Van Kanegan, M. J., D. G. Adams, B. E. Wadzinski, and S. Strack. 2005. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J. Biol. Chem. 280:36029-36036.
    • (2005) J. Biol. Chem , vol.280 , pp. 36029-36036
    • Van Kanegan, M.J.1    Adams, D.G.2    Wadzinski, B.E.3    Strack, S.4
  • 52
    • 0029808748 scopus 로고    scopus 로고
    • Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
    • Whitmarsh, A. J., and R. J. Davis. 1996. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74:589-607.
    • (1996) J. Mol. Med , vol.74 , pp. 589-607
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 53
    • 0033616588 scopus 로고    scopus 로고
    • Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
    • Wysk, M., D. D. Yang, H. T. Lu, R. A. Flavell, and R. J. Davis. 1999. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA 96:3763-3768.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3763-3768
    • Wysk, M.1    Yang, D.D.2    Lu, H.T.3    Flavell, R.A.4    Davis, R.J.5
  • 54
    • 0142188706 scopus 로고    scopus 로고
    • Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy
    • Yang, L., Z. Cao, H. Yan, and W. C. Wood. 2003. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res. 63:6815-6824.
    • (2003) Cancer Res , vol.63 , pp. 6815-6824
    • Yang, L.1    Cao, Z.2    Yan, H.3    Wood, W.C.4
  • 55
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • Zarubin, T., and J. Han. 2005. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15:11-18.
    • (2005) Cell Res , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.