Imaging of distribution of topically applied drug molecules in mouse skin by combination of time-of-flight secondary ion mass spectrometry and scanning electron microscopy

Analytical Chemistry

Volumn 86, Issue 7, 2014, Pages 3443-3452

  Sjövall, Peter ^a   Greve, Tanja M ^b   Clausen, Susanne K ^b   Moller, Kristian ^b   Eirefelt, Stefan ^b   Johansson, Björn ^c   Nielsen, Kim T ^b  

^a SP TECHNICAL RESEARCH INSTITUTE OF SWEDEN   (Sweden)

^b LEO PHARMA A S   (Denmark)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; MOLECULES; PHARMACOKINETICS; PHOSPHOLIPIDS; SCANNING ELECTRON MICROSCOPY; SPATIAL DISTRIBUTION;

DRUG DISTRIBUTION; DRUG PENETRATION; MASS SPECTROMETRIC IMAGING; MICROMOLAR RANGE; MILLIMOLAR RANGE; PHYSICOCHEMICAL PROPERTY; TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; TOPICAL APPLICATION;

SECONDARY ION MASS SPECTROMETRY;

ANIMAL; BAGG ALBINO MOUSE; FEMALE; MASS SPECTROMETRY; METABOLISM; MOUSE; PHARMACOKINETICS; PROCEDURES; SCANNING ELECTRON MICROSCOPY; SKIN; TOPICAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; FEMALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; PHARMACOKINETICS; SKIN; SPECTROMETRY, MASS, SECONDARY ION;

EID: 84897494112     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac403924w     Document Type: Article

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