Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma

Oncotarget

Volumn 5, Issue 4, 2014, Pages 882-893

  Li, Jie ^a   Zhu, Shan ^b   Kozono, David ^b   Ng, Kimberly ^a   Futalan, Diahnn ^a   Shen, Ying ^a   Akers, Johnny C ^a   Steed, Tyler ^a   Kushwaha, Deepa ^b   Schlabach, Michael ^c   Carter, Bob S ^a   Kwon, Chang Hyuk ^d   Furnari, Frank ^e   Cavenee, Webster ^e   Elledge, Stephen ^b   Chen, Clark C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^e LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

DRD2; EGFR; Glioblastoma; Mitogenic signaling

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; HALOPERIDOL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; RAS PROTEIN; SHORT HAIRPIN RNA; DRD2 PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRD2 GENE; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; EGFR GENE; GENE; GENE IDENTIFICATION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC SCREENING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOGENESIS; MOUSE; MOUSE MODEL; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN TUMOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOBLASTOMA; HETEROGRAFTS; HUMANS; MICE; MICE, NUDE; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, DOPAMINE D2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84897419234     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1801     Document Type: Article

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