Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Homma, Takujiro ^a   Ishibashi, Daisuke ^a   Nakagaki, Takehiro ^a   Satoh, Katsuya ^a   Sano, Kazunori ^a   Atarashi, Ryuichiro ^a   Nishida, Noriyuki ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; PRION; PRION PROTEIN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE; UBIQUITIN;

ANIMAL; BRAIN; DISEASE MODEL; GENE EXPRESSION; GENETICS; LYSOSOME; METABOLISM; MOUSE; PRION; PRION DISEASE; PROTEIN DEGRADATION; PROTEIN TRANSPORT; PROTEINOSIS; TUMOR CELL LINE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BRAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HEAT-SHOCK PROTEINS; LYSOSOMES; MICE; PRION DISEASES; PRIONS; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEOLYSIS; PRPSC PROTEINS; UBIQUITIN; UP-REGULATION;

EID: 84897147170     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04504     Document Type: Article

References (49)

1. Prusiner, S. B. Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144 (1982 (Pubitemid 12089840)
2. Bockman, J. M., Kingsbury, D. T., McKinley, M. P., Bendheim, P. E. & Prusiner, S. B. Creutzfeldt-Jakob disease prion proteins in human brains. N. Engl. J. Med. 312, 73-78 (1985 (Pubitemid 15192136)
3. Prusiner, S. B. et al. Scrapie prions aggregate to form amyloid-like birefringent rods. Cell 35, 349-358 (1983 (Pubitemid 14202913)
4. Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R. & Finkbeiner, S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431, 805-810 (2004 (Pubitemid 39434070)
5. Kristiansen, M. et al. Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol. Cell 26, 175-188 (2007 (Pubitemid 46617340)
6. Rubinsztein, D. C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443, 780-786 (2006 (Pubitemid 44622682)
7. Bennett, E. J., Bence, N. F., Jayakumar, R.&Kopito, R. R. Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol. Cell 17, 351-365 (2005 (Pubitemid 40193307)
8. Garcia-Mata, R., Gao, Y. S. & Sztul, E. Hassles with taking out the garbage: aggravating aggresomes. Traffic 3, 388-396 (2002 (Pubitemid 34746406)
9. Johnston, J. A., Ward, C. L. & Kopito, R. R. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143, 1883-1898 (1998 (Pubitemid 29022611)
10. Johnston, J. A., Illing, M. E. & Kopito, R. R. Cytoplasmic dynein/dynactin mediates the assembly of aggresomes. Cell Motil. Cytoskelet. 53, 26-38 (2002 (Pubitemid 34984442)
11. Bjrky, G. et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171, 603-614 (2005
12. Ichimura, Y. et al. Structural basis for sorting mechanism of p62 in selective autophagy. J. Biol. Chem. 283, 22847-22857 (2008
13. Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-63 (2007 (Pubitemid 350235021)
14. Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007 (Pubitemid 47328003)
15. Iwata, A., Riley, B. E., Johnston, J. A.&Kopito, R. R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280, 40282-40292 (2005 (Pubitemid 41779165)
16. Pandey, U. B. et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863 (2007 (Pubitemid 46920134)
17. Babu, J. R., Geetha, T. & Wooten, M. W. Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. J. Neurochem. 94, 192-203 (2005 (Pubitemid 40911405)
18. Kuusisto, E., Suuronen, T. & Salminen, A. Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. Biochem. Biophys. Res. Commun. 280, 223-228 (2001 (Pubitemid 32917500)
19. Nakano, T., Nakaso, K., Nakashima, K. & Ohama, E. Expression of ubiquitinbinding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum. Acta Neuropathol. 107, 359-364 (2004 (Pubitemid 38477363)
20. Nakaso, K. et al. Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinsons disease. Brain Res. 1012, 42-51 (2004 (Pubitemid 38648897)
21. Tanji, K. et al. p62/sequestosome 1 binds to TDP-43 in brainswith frontotemporal lobar degeneration with TDP-43 inclusions. J. Neurosci. Res. 000, 1-9 (2012
22. Zatloukal, K. et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am. J. Pathol. 160, 255-263 (2002 (Pubitemid 34052286)
23. Aguib, Y., Heiseke, A., Gilch, S. & Riemer, C. Autophagy induction by trehalose counteracts cellular prion infection. Autophagy 361-369 (2009
24. Heiseke, A., Aguib, Y., Riemer, C., Baier, M. & Schatzl, H. M. Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy. J. Neurochem. 109, 25-34 (2009
25. Nakagaki, T. et al. FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy 9, 1-9 (2013
26. Ma, J. & Lindquist, S. Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc. Natl. Acad. Sci. U S A 98, 14955-14960 (2001 (Pubitemid 34013951)
27. Yedidia, Y., Horonchik, L., Tzaban, S., Yanai, A. & Taraboulos, A. Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein. EMBO J. 20, 5383-5391 (2001 (Pubitemid 32959458)
28. Drisaldi, B. et al.Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation. J. Biol. Chem. 278, 21732-43 (2003 (Pubitemid 36792576)
29. Fioriti, L. et al. Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations. J. Biol. Chem. 280, 11320-8 (2005 (Pubitemid 40418439)
30. Rane,N. S., Yonkovich, J. L.&Hegde, R. S. Protection from cytosolic prion protein toxicity by modulation of protein translocation. EMBO J. 23, 4550-9 (2004 (Pubitemid 39657855)
31. Shin, J. P62 and the sequestosome, a novel mechanism for protein metabolism. Arch. Pharm. Res. 21, 629-633 (1998 (Pubitemid 128668388)
32. Taraboulos, A., Serban, D. & Prusiner, S. B. Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J. Cell Biol. 110, 2117-2132 (1990
33. Seibenhener, M. L. et al. Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation. Mol. Cell. Biol. 24, 8055-8068 (2004 (Pubitemid 39167456)
34. Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M. & Nukina, N. Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins. Mol. Cell 44, 279-289 (2011
35. Xu, Y. et al. Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases. Autophagy 8, 1604-1620 (2012
36. Ishii, T. et al. Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 232, 33-37 (1997 (Pubitemid 27211914)
37. Deriziotis, P. et al. Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J. 30, 3065-3077 (2011
38. Jain, A. et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285, 22576-22591 (2010
39. Yamamoto, N. et al. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. J. Biol. Chem. 282, 4364-72 (2007 (Pubitemid 47101000)
40. Komatsu, M. et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 12, 213-223 (2010
41. Ironside, J. W., McCardle, L., Hayward, P. A. & Bell, J. E. Ubiquitin immunocytochemistry in human spongiform encephalopathies. Neuropathol. Appl. Neurobiol. 19, 134-140 (1993 (Pubitemid 23136222)
42. Kovacs, G. G., Preusser, M., Strohschneider, M. & Budka, H. Subcellular localization of disease-associated prion protein in the human brain. Am. J. Pathol. 166, 287-294 (2005 (Pubitemid 40051680)
43. Watanabe, Y. et al. p62/SQSTM1-dependent autophagy of Lewy body-like alphasynuclein inclusions. PLoS One 7, e52868 (2012
44. Doi, H. & Adachi, H. p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model. J. Neurosci. 33(18), 7710-7727 (2013
45. Xu, Y. et al. Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way. Med. Microbiol. Immunol. (2013
46. doi:10.1007/s00430-013-0316-z. 46. Atarashi, R., Sim, V. L., Nishida, N., Caughey, B. & Katamine, S. Prion straindependent differences in conversion of mutant prion proteins in cell culture. J. Virol. 80, 7854-62 (2006 (Pubitemid 44182286)
47. Nishida, N. et al. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J. Virol. 74, 320-325 (2000 (Pubitemid 30002912)
48. Iwamaru, Y. et al. Microglial cell line established from prion proteinoverexpressing mice is susceptible to various murine prion strains. J. Virol. 81, 1524-1527 (2007 (Pubitemid 46167875)
49. Ishibashi, D. et al. Protective role of interferon regulatory factor 3-mediated signaling against prion infection. J. Virol. 86, 4947-4955 (2012