Absolute proteomic quantification of the activity state of proteases and proteolytic cleavages using proteolytic signature peptides and isobaric tags

Journal of Proteomics

Volumn 100, Issue , 2014, Pages 79-91

  Fahlman, Richard P ^a   Chen, Wei ^a   Overall, Christopher M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Degradomics; ITRAQ synthesis; MMPs; Protease; Proteolytic cleavages; Proteomics

Indexed keywords

CARBON 13; ENZYME PRECURSOR; GELATINASE A; INTERSTITIAL COLLAGENASE; NEUTROPHIL COLLAGENASE; PEPTIDE; PROTEINASE; PROTEOLYTIC SIGNATURE PEPTIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; CARBON; MATRIX METALLOPROTEINASE; PEPTIDE HYDROLASE; TRYPSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOBARIC TAGS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN PROCESSING; PROTEOMICS; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; ZYMOGRAPHY; CHEMISTRY; ISOTOPE LABELING; METABOLISM; PROCEDURES; SENSITIVITY AND SPECIFICITY;

CARBON ISOTOPES; HUMANS; ISOTOPE LABELING; MATRIX METALLOPROTEINASES; PEPTIDE HYDROLASES; PEPTIDES; PROTEOLYSIS; PROTEOMICS; SENSITIVITY AND SPECIFICITY; TRYPSIN;

EID: 84897097267     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2013.09.006     Document Type: Article

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