Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat

Neuroscience

Volumn 267, Issue , 2014, Pages 122-134

  Nag, S ^a   Mokha, S S ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

Analgesia; Clonidine; Estrogen; Pain; Sex differences; Spinal cord

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA 2 ADRENERGIC RECEPTOR; ANISOMYCIN; BOVINE SERUM ALBUMIN; CLONIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIARYLPROPIONITRILE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED RECEPTOR 30; GQ COUPLED MEMBRANE ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; ESTRADIOL-BOVINE SERUM ALBUMIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; GENOMICS; IMMUNOBLOTTING; IN VIVO STUDY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; RAT MODEL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TAIL FLICK TEST; TRANSCRIPTION REGULATION; ANIMAL; BOVINAE; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; METABOLISM; NOCICEPTION; PAIN MEASUREMENT; REACTION TIME; SPINAL CORD; SPRAGUE DAWLEY RAT; TIME;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; CATTLE; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; ESTRADIOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; NOCICEPTION; OVARIECTOMY; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA-2; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION; SPINAL CORD; TIME FACTORS;

EID: 84897035558     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.02.040     Document Type: Article

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