A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis

Journal of Neuroscience

Volumn 26, Issue 21, 2006, Pages 5649-5655

  Qiu, Jian ^a   Bosch, Martha A ^a   Tobias, Sandra C ^c   Krust, Andree ^e   Graham, Sharon M ^b   Murphy, Stephanie J ^b   Korach, Kenneth S ^d   Chambon, Pierre ^e   Scanlan, Thomas S ^c   Rønnekleiv, Oline K ^a   Kelly, Martin J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e CNRS   (France)

Author keywords

Body weight; GABAB receptor; GPCR; Intracellular signaling; POMC neurons; Potassium channels

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR X; G PROTEIN COUPLED ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; ENERGY METABOLISM; FEMALE; GUINEA PIG; HOMEOSTASIS; HYPOTHALAMUS; IN VITRO STUDY; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POSTMENOPAUSE; PRIORITY JOURNAL; SLEEP PATTERN; STRESS; THERMOREGULATION; WEIGHT GAIN; ANIMAL; BODY WEIGHT; C57BL MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BODY WEIGHT; ENERGY METABOLISM; FEMALE; GUINEA PIGS; HOMEOSTASIS; HYPOTHALAMUS; MICE; MICE, INBRED C57BL; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 33744970064     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0327-06.2006     Document Type: Article

References (43)

1. American College of Obstetricians and Gynecologists (2005) Body mass index and insulin resistance. Obstet Gynecol 104:5s-10s.
2. Blaustein JD (1994) Estrogen receptors in neurons: new subcellular locations and functional implications. Endocr J 2:249-258.
3. Butera PC, Czaja JA (1984) Intracranial estradiol in ovariectomized guinea pigs: effects on ingestive behaviors and body weight. Brain Res 322:41-48.
4. Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578.
5. 35S]GTPgammaS binding in guinea pig hypothalamus: effects of estrogen. Brain Res 791:341-346.
6. Czaja JA, Goy RW (1975) Ovarian hormones and food intake in female guinea pigs and rhesus monkeys. Horm Behav 6:329-349.
7. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M (2000) Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127:4277-4291.
8. Filardo EJ, Quinn JA, Frackelton Jr AR, Bland KI (2002) Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol 16:70-84.
9. Fodor M, Delemarre-van de Waal HA (2001) Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat? NeuroReport 12:3989-3991.
10. Frawley LS, Neill JD (1980) Effect of estrogen on serum prolactin levels in rhesus monkeys after hypophyseal stalk transection. Biol Reprod 22:1089-1093.
11. Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK (2002) Activation of central melanocortin pathways by fenfluramine. Science 297:609-611.
12. Horvath TL (2005) The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci 8:561-565.
13. Jobst EE, Enriori PJ, Cowley MA (2004) The electrophysiology of feeding circuits. Trends Endocrinol Metab 15:488-499.
14. Kelly MJ, Levin ER (2001) Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol Metab 12:152-156.
15. B-mediated hyperpolarization of hypothalamic arcuate neurons. J Neurosci 12:2745-2750.
16. Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK (1999) Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids 64:64-75.
17. Komesaroff PA, Sudhir K, Esler MD (1999) Effects of estrogen on stress responses in women. J Clin Endocrinol Metab 84:4292-4293.
18. Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13:177-184.
19. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JÅ, Smithies O (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA 95:15677-15682.
20. Lagrange AH, Rønnekleiv OK, Kelly MJ (1994) The potency of μ-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17β-estradiol. J Neurosci 14:6196-6204.
21. B response in hypothalamic neurons. Neuroendocrinology 64:114-123.
22. Lagrange AH, Rønnekleiv OK, Kelly MJ (1997) Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A. Mol Pharmacol 51:605-612.
23. McEwen BS, Alves SE (1999) Estrogen actions in the central nervous system. Endocr Rev 20:279-307.
24. Milewicz A, Bidzinska B, Mikulski E, Demissie M, Tworowska U (2000) Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels. Gynecol Endocrinol 14:196-203.
25. Milewicz A, Tworowska U, Demissie M (2001) Menopausal obesity-myth or fact? Climacteric 4:273-283.
26. Murphy KG, Bloom SR (2005) Peripheral influences on central melanocortin neurons. Peptides 26:1744-1752.
27. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LFJ, George SR (1998) Discovery of three novel G-protein-coupled receptor genes. Genomics 47:310-313.
28. Qiu J, Bosch MA, Tobias SC, Grandy DK, Scanlan TS, Rønnekleiv OK, Kelly MJ (2003) Rapid signaling of estrogen in hypothalamic neurons involves a novel G protein-coupled estrogen receptor that activates protein kinase C. J Neurosci 23:9529-9540.
29. Qiu J, Bosch MA, Rønnekleiv OK, Kelly MJ (2005) Convergence of membrane estrogen receptor and serotonin 5 HT2A/C receptor signaling in hypothalamic neurons. Soc Neurosci Abstr 31632.5.
30. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307:1625-1630.
31. Rønnekleiv OK, Kelly MJ (2005) Diversity of ovarian steroid signaling in the hypothalamus. Front Neuroendocrinol 26:65-84.
32. Saper CB, Chou TC, Elmquist JK (2002) The need to feed: homeostatic and hedonic control of eating. Neuron 36:199-211.
33. Sherwin BB (2002) Estrogen and cognitive aging in women. Trends Pharmacol Sci 23:527-534.
34. Shughrue PJ, Lane MV, Merchenthaler I (1997) Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525.
35. Sodersten P, Bergh C, Ammar (2003) Anorexia nervosa: towards a neurobiologically based therapy. Eur J Pharmacol 480:67-74.
36. Stearns V, Ullmer L, Lopez JF, Smith Y, Isaacs C, Hayes DF (2002) Hot flushes. Lancet 360:1851-1861.
37. Stearns V, Johnson MD, Rae JM, Morocho A, Novielli A, Bhargava P, Hayes DF, Desta Z, Flockhart DA (2003) Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764.
38. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374:542-546.
39. Thomas P, Pang Y, Filardo EJ, Dong J (2005) Identity of an estrogen membrane receptor coupled to a G-protein in human breast cancer cells. Endocrinology 146:624-632.
40. Tobias SC, Qiu J, Kelly MJ, Scanlan TS (2006) Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. Chem Med Chem 1:565-571.
41. Toran-Allerand CD, Singh M, Setalo Jr G (1999) Novel mechanisms of estrogen action in the brain: New players in an old story. Front Neuroendocrinol 20:97-121.
42. Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly Jr ES, Nethrapalli IS, Tinnikov AA (2002) ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci 22:8391-8401.
43. Wilson ME, Mook D, Graves F, Felger J, Bielsky IF, Wallen K (2003) Tamoxifen is an estrogen antagonist on gonadotropin secretion and responsiveness of the hypothalamic-pituitary-adrenal axis in female monkeys. Endocrine 22:305-315.