Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways

Blood

Volumn 123, Issue 5, 2014, Pages

  Beck, Florian ^a   Geiger, Jörg ^b   Gambaryan, Stepan ^b,c   Veit, Johannes ^d   Vaudel, Marc ^a   Nollau, Peter ^e   Kohlbacher, Oliver ^d   Martens, Lennart ^f,g   Walter, Ulrich ^h   Sickmann, Albert ^a,i   Zahedi, René P ^a  

^a LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f Vlaams Instituut voor Biotechnologie   (Belgium)

^g GHENT UNIVERSITY   (Belgium)

^h UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

ⁱ RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ILOPROST; PEPTIDE DERIVATIVE; ANTITHROMBOCYTIC AGENT; CYCLIC AMP;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOCYTE INHIBITION; UBIQUITINATION; CYTOLOGY; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

BLOOD PLATELETS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; ILOPROST; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTEIN INTERACTION MAPS; SIGNAL TRANSDUCTION;

EID: 84897012538     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-07-512384     Document Type: Article

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