-
1
-
-
0036723795
-
The VA and VCD spectra of various isotopes of L-alanine in aqueous solution
-
ABDALI, S., JALKANEN, K. J., BOHR, H., SUHAI, S., and NIEMINEN, R. M. (2002). The VA and VCD spectra of various isotopes of L-alanine in aqueous solution. Chem. Phys. 282, 219-235.
-
(2002)
Chem. Phys.
, vol.282
, pp. 219-235
-
-
Abdali, S.1
Jalkanen, K.J.2
Bohr, H.3
Suhai, S.4
Nieminen, R.M.5
-
2
-
-
18844455464
-
Second generation OD antisense oligonucleotides: From nuclease resistance to biological efficacy in animals
-
ALTMANN, K.-H., DEAN, N. M., FABBRO, D., FREIER, S. M., GEIGER, T., HÄ NER, R., HÜ SKEN, D., MARTIN, P., MONIA, B. P., MÜ LLER, M., et al. (1996). Second generation OD antisense oligonucleotides: from nuclease resistance to biological efficacy in animals. Chimia 50, 168-176.
-
(1996)
Chimia
, vol.50
, pp. 168-176
-
-
Altmann, K.-H.1
Dean, N.M.2
Fabbro, D.3
Freier, S.M.4
Geiger, T.5
Hä Ner, R.6
Hü Sken, D.7
Martin, P.8
Monia, B.P.9
Mü Ller, M.10
-
3
-
-
0028956615
-
Binding, uptake, and intracellular trafficking of phosphorothioate- modified oligodeoxynucleotides
-
BELTINGER, C., SARAGOVI, H. U., SMITH, R. M., LESAUTEUR, L., SHAH, N., DEDIONISIO, L., CHRISTENSEN, L., RAIBLE, A., JARETT, L., and GEWIRTZ, A. M. (1995). Binding, uptake, and intracellular trafficking of phosphorothioate- modified oligodeoxynucleotides. J. Clin. Invest 95, 1814-1823.
-
(1995)
J. Clin. Invest
, vol.95
, pp. 1814-1823
-
-
Beltinger, C.1
Saragovi, H.U.2
Smith, R.M.3
Lesauteur, L.4
Shah, N.5
Dedionisio, L.6
Christensen, L.7
Raible, A.8
Jarett, L.9
Gewirtz, A.M.10
-
4
-
-
84896956943
-
Perspectives in quantum nanobiology and biophysical chemistry
-
BOHR, H. G. (2013). Perspectives in quantum nanobiology and biophysical chemistry. Current Phys. Chem. 3, 4-8.
-
(2013)
Current Phys. Chem.
, vol.3
, pp. 4-8
-
-
Bohr, H.G.1
-
5
-
-
33745597909
-
Predicting protein interaction sites: Binding hot-spots in protein-protein and protein-ligand interfaces
-
BURGOYNE, N. J., and JACKSON, R. M. (2006). Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces. Bioinformatics 22, 1335-1342.
-
(2006)
Bioinformatics
, vol.22
, pp. 1335-1342
-
-
Burgoyne, N.J.1
Jackson, R.M.2
-
6
-
-
0031891022
-
Computation of electrostatic complements to proteins: A case of charge stabilized binding
-
CHONG, L. T., DEMPSTER, S. E., HENDSCH, Z. S., LEE, L. P., and TIDOR, B. (1998). Computation of electrostatic complements to proteins: a case of charge stabilized binding. Protein Sci. 7, 206-210.
-
(1998)
Protein Sci.
, vol.7
, pp. 206-210
-
-
Chong, L.T.1
Dempster, S.E.2
Hendsch, Z.S.3
Lee, L.P.4
Tidor, B.5
-
8
-
-
0032811602
-
Making drugs out of oligonucleotides: A brief review and perspective
-
COOK, P. D. (1999). Making drugs out of oligonucleotides: a brief review and perspective. Nucleosides Nucleotides 18, 1141-1162.
-
(1999)
Nucleosides Nucleotides
, vol.18
, pp. 1141-1162
-
-
Cook, P.D.1
-
9
-
-
0030917307
-
Peptide nucleic acids: Expanding the scope of recognition
-
COREY, D. R. (1997). Peptide nucleic acids: expanding the scope of recognition. TIBTECH 15, 224-229.
-
(1997)
TIBTECH
, vol.15
, pp. 224-229
-
-
Corey, D.R.1
-
11
-
-
33646715590
-
Improved targeting of miRNA with antisense oligonucleotides
-
DAVIS, S., LOLLO, B., FREIER, S., and ESAU, C. (2006). Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res. 34, 2294-2304.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2294-2304
-
-
Davis, S.1
Lollo, B.2
Freier, S.3
Esau, C.4
-
12
-
-
34247642239
-
Chemical modifications to improve the cellular uptake of oligonucleotides
-
DEBART, F., ABES, S., DEGLANE, G., MOULTON, H. M., CLAIR, P., GAIT, M. J., VASSEUR, J. J., and LEBLEU, B. (2007). Chemical modifications to improve the cellular uptake of oligonucleotides. Curr. Top. Med. Chem. 7, 727-737.
-
(2007)
Curr. Top. Med. Chem.
, vol.7
, pp. 727-737
-
-
Debart, F.1
Abes, S.2
Deglane, G.3
Moulton, H.M.4
Clair, P.5
Gait, M.J.6
Vasseur, J.J.7
Lebleu, B.8
-
13
-
-
0442323636
-
Two sides of the coin: Affinity and specificity of nucleic acid interaction
-
DEMIDOV, V. V., and FRANK-KAMENETSKII, M. D. (2004). Two sides of the coin: affinity and specificity of nucleic acid interaction. Trends Biochem. Sci. 29, 62-71.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 62-71
-
-
Demidov, V.V.1
Frank-Kamenetskii, M.D.2
-
14
-
-
55849117326
-
An appraisal of Poincaré-Hopf relation and application to topography of molecular electrostatic potentials
-
DHIMOY, R. K., BALANARAYAN, P., ANDSHRIDHAR, G. R. (2008). An appraisal of Poincaré-Hopf relation and application to topography of molecular electrostatic potentials. J. Chem. Phys. 129, 174103.
-
(2008)
J. Chem. Phys.
, vol.129
, pp. 174103
-
-
Dhimoy, R.K.1
Balanarayan, P.2
Andshridhar, G.R.3
-
15
-
-
70449372104
-
Signatures of molecular recognition from topography of electrostatic potential
-
DHIMOY, R. K., BALANARAYAN, P., and SHRIDHAR, G. R. (2013). Signatures of molecular recognition from topography of electrostatic potential. J. Chem. Sci. 121, 815-821.
-
(2013)
J. Chem. Sci.
, vol.121
, pp. 815-821
-
-
Dhimoy, R.K.1
Balanarayan, P.2
Shridhar, G.R.3
-
16
-
-
34547668773
-
The versatility of oligonucleotides as potential therapeutics
-
ECKSTEIN, F. (2007). The versatility of oligonucleotides as potential therapeutics. Expert. Opin. Biol. Ther. 7, 1021-1034.
-
(2007)
Expert. Opin. Biol. Ther.
, vol.7
, pp. 1021-1034
-
-
Eckstein, F.1
-
17
-
-
42249093319
-
LNA-mediated microRNA silencing in non-human primates
-
ELMEN, J., LINDOW, M., SCHUTZ, S., LAWRENCE, M., PETRI, A., OBAD, S., LINDHOLM, M., HEDTJARN, M., HANSEN, H. F., BERGER, U., GULLANS, S., KEARNEY, P., SARNOW, P., STRAARUP, E. M., and KAUPPINEN, S. (2008a). LNA-mediated microRNA silencing in non-human primates. Nature 452, 896-899.
-
(2008)
Nature
, vol.452
, pp. 896-899
-
-
Elmen, J.1
Lindow, M.2
Schutz, S.3
Lawrence, M.4
Petri, A.5
Obad, S.6
Lindholm, M.7
Hedtjarn, M.8
Hansen, H.F.9
Berger, U.10
Gullans, S.11
Kearney, P.12
Sarnow, P.13
Straarup, E.M.14
Kauppinen, S.15
-
18
-
-
40249106014
-
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
-
ELMEN, J., LINDOW, M., SILAHTAROGLU, A., BAK, M., CHRISTENSEN, M., LIND-THOMSEN, A., HEDTJARN, M., HANSEN, J. B., HANSEN, H. F., STRAARUP, E. M., MCCULLAGH, K., KEARNEY, P., and KAUPPINEN, S. (2008b). Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 36, 1153-1162.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 1153-1162
-
-
Elmen, J.1
Lindow, M.2
Silahtaroglu, A.3
Bak, M.4
Christensen, M.5
Lind-Thomsen, A.6
Hedtjarn, M.7
Hansen, J.B.8
Hansen, H.F.9
Straarup, E.M.10
McCullagh, K.11
Kearney, P.12
Kauppinen, S.13
-
19
-
-
0030727765
-
The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes
-
FREIER, S. M., and ALTMANN, K.-H. (1997). The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes. Nucleic Acid Res. 25, 4429-4443.
-
(1997)
Nucleic Acid Res.
, vol.25
, pp. 4429-4443
-
-
Freier, S.M.1
Altmann, K.-H.2
-
20
-
-
84896998593
-
-
Gaussian, Inc., Wallingford CT
-
FRISCH, M. J., TRUCKS, G. W.; SCHLEGEL, H. B.; SCUSERIA, G. E.; ROBB, M. A.; CHEESEMAN, J. R.; SCALMANI, G.; BARONE, V.; MENNUCCI, B.; PETERSSON, G. A., et al. (2009). Gaussian 09, (Gaussian, Inc., Wallingford CT)
-
(2009)
Gaussian
, vol.9
-
-
Frisch, M.J.1
Trucks, G.W.2
Schlegel, H.B.3
Scuseria, G.E.4
Robb, M.A.5
Cheeseman, J.R.6
Scalmani, G.7
Barone, V.8
Mennucci, B.9
Petersson, G.A.10
-
21
-
-
84883404077
-
Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern
-
HAGEDORN, P. H., YAKIMOV, V., OTTOSEN, S., KAMMLER, S., NIELSEN, N. F., HOG, A. M., HEDTJARN, M., MELDGAARD, M., MOLLER, M. R., ORUM, H., et al. (2013). Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern. Nucleic Acid Ther. 23, 302-310.
-
(2013)
Nucleic Acid Ther.
, vol.23
, pp. 302-310
-
-
Hagedorn, P.H.1
Yakimov, V.2
Ottosen, S.3
Kammler, S.4
Nielsen, N.F.5
Hog, A.M.6
Hedtjarn, M.7
Meldgaard, M.8
Moller, M.R.9
Orum, H.10
-
22
-
-
54049085042
-
SPC3042: A proapoptotic survivin inhibitor
-
HANSEN, J. B., FISKER, N., WESTERGAARD, M., KJAERULFF, L. S., HANSEN, H. F., THRUE, C. A., ROSENBOHM, C., WISSENBACH, M., ORUM, H., and KOCH, T. (2008). SPC3042: a proapoptotic survivin inhibitor. Mol. Cancer Ther. 7, 2736-2745.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2736-2745
-
-
Hansen, J.B.1
Fisker, N.2
Westergaard, M.3
Kjaerulff, L.S.4
Hansen, H.F.5
Thrue, C.A.6
Rosenbohm, C.7
Wissenbach, M.8
Orum, H.9
Koch, T.10
-
23
-
-
0027104702
-
Antisense and antigene properties of peptide nucleic acid
-
HANVEY, J. C., PEFFER, N. J., BISI, J. E., THOMSON, S. A., CADILLA, R., JOSEY, J. A., RICCA, D. J., HASSMAN, C. F., BONHAM, M. A., AU, K. G., et al. (1992). Antisense and antigene properties of peptide nucleic acid. Science 258, 1481-1485.
-
(1992)
Science
, vol.258
, pp. 1481-1485
-
-
Hanvey, J.C.1
Peffer, N.J.2
Bisi, J.E.3
Thomson, S.A.4
Cadilla, R.5
Josey, J.A.6
Ricca, D.J.7
Hassman, C.F.8
Bonham, M.A.9
-
24
-
-
84872522659
-
Opposite attract: Shape and electrostatic complementarity in Protein-DNA Complexes
-
Royal Society of Chemistry
-
HARRIS, C. R., MACKOY, T., MACHADO C. D. ANA, XU, D., ROHS, R., and FENLEY, O. M. (2012). Opposite attract: shape and electrostatic complementarity in Protein-DNA Complexes. In: Innovations in Biomolecular Modeling and Simulations, Volume 2. T. Schlick, ed. (Royal Society of Chemistry), pp. 53-80.
-
(2012)
Innovations in Biomolecular Modeling and Simulations, Volume 2. T. Schlick
, pp. 53-80
-
-
Harris, C.R.1
Mackoy, T.2
Machado, D.C.3
Ana, X.U.D.4
Rohs, R.5
Fenley, O.M.6
-
25
-
-
79958818207
-
Role of heat capacity change in understanding and modeling melting thermodynamics of complementary duplexes containing standard and nucleobase-modified LNA
-
HUGHESMANN, C. B., TURNER, R. F. B., and HAYNES C. A. (2011). Role of heat capacity change in understanding and modeling melting thermodynamics of complementary duplexes containing standard and nucleobase-modified LNA. Biochemistry 50, 5354-5368.
-
(2011)
Biochemistry
, vol.50
, pp. 5354-5368
-
-
Hughesmann, C.B.1
Turner, R.F.B.2
Haynes, C.A.3
-
26
-
-
0035313507
-
A comparison of aqueous solvent models used in the calculation of the Raman and ROA spectra od L-alanine
-
JALKANEN J. K, NIEMINEN M. R., FRIMAND K., BOHR J., BOHR H., WADE C. R., TAJKHORSHID E., and SUHAI S. (2001). A comparison of aqueous solvent models used in the calculation of the Raman and ROA spectra od L-alanine. Chem. Phys. 265, 125-151.
-
(2001)
Chem. Phys.
, vol.265
, pp. 125-151
-
-
Jalkanen, K.J.1
Nieminen, M.R.2
Frimand, K.3
Bohr, J.4
Bohr, H.5
Wade, C.R.6
Tajkhorshid, E.7
Suhai, S.8
-
29
-
-
66249086550
-
Hydrogen bonding, electrostatic potential, and molecular design
-
KENNY, P. W. (2009). Hydrogen bonding, electrostatic potential, and molecular design. J. Chem. Inf. Model. 49, 1234-1244.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 1234-1244
-
-
Kenny, P.W.1
-
30
-
-
84879838868
-
LNA antisense: A review
-
KOCH, T. (2013). LNA antisense: a review. Curr. Phys. Chem. 3, 55-68.
-
(2013)
Curr. Phys. Chem.
, vol.3
, pp. 55-68
-
-
Koch, T.1
-
31
-
-
85020060298
-
Locked nucleic acid
-
CRC Press: Boca Raton, FL
-
KOCH, T., and ØRUM, H. (2007). Locked nucleic acid. In: Antisense Drug Discovery. S. T. Crooke, ed. (CRC Press: Boca Raton, FL), pp. 519-565.
-
(2007)
Antisense Drug Discovery. S. T. Crooke
, pp. 519-565
-
-
Koch, T.1
Ørum, H.2
-
32
-
-
65249165824
-
Locked nucleic acid: Properties and therapeutic aspects
-
RSC Publishing: Cambridge, UK
-
KOCH, T., ROSENBOHM, C., HANSEN, H. F., F., HANSEN, B., STRAARUP, E. M., and KAUPPINEN, S. (2008). Locked nucleic acid: properties and therapeutic aspects. In: Therapeutic Oligonucleotides. Jens Kurreck, ed. (RSC Publishing: Cambridge, UK), pp. 103-141.
-
(2008)
Therapeutic Oligonucleotides. Jens Kurreck
, pp. 103-141
-
-
Koch, T.1
Rosenbohm, C.2
Hansen, H.F.F.3
Hansen, B.4
Straarup, E.M.5
Kauppinen, S.6
-
33
-
-
79959479529
-
Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
-
KOLLER, E., VINCENT, T. M., CHAPPELL, A., DE, S., MANOHARAN, M., and BENNETT, C. F. (2011). Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes. Nucleic Acids Res. 39, 4795-4807.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 4795-4807
-
-
Koller, E.1
Vincent, T.M.2
Chappell, A.3
De, S.4
Manoharan, M.5
Bennett, C.F.6
-
34
-
-
33646262869
-
Testing electrostatic complementarity in enzyme catalysis: Hydrogen bonding in the ketosteroid isomerase oxyanion hole
-
KRAUT, D. A., SIGALA, P. A., PYBUS, B., LIU, C. W., RINGE, D., PETSKO, G. A., and HERSCHLAG, D. (2006). Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole. PLoS Biol. 4, e99.
-
(2006)
PLoS Biol.
, vol.4
-
-
Kraut, D.A.1
Sigala, P.A.2
Pybus, B.3
Liu, C.W.4
Ringe, D.5
Petsko, G.A.6
Herschlag, D.7
-
35
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
KRUTZFELDT, J., RAJEWSKY, N., BRAICH, R., RAJEEV, K. G., TUSCHL, T., MANOHARAN, M., and STOFFEL, M. (2005). Silencing of microRNAs in vivo with 'antagomirs'. Nature 438, 685-689.
-
(2005)
Nature
, vol.438
, pp. 685-689
-
-
Krutzfeldt, J.1
Rajewsky, N.2
Braich, R.3
Rajeev, K.G.4
Tuschl, T.5
Manoharan, M.6
Stoffel, M.7
-
36
-
-
33846322573
-
Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency
-
LAI, J. C., BROWN, B. D., VOSKRESENSKIY, A. M., VONHOFF, S., KLUSSMAN, S., TAN, W., COLOMBINI, M., WEERATNA, R., MILLER, P., BENIMETSKAYA, L., and STEIN, C. A. (2007A). Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency. Mol. Ther. 15, 270-278.
-
(2007)
Mol. Ther.
, vol.15
, pp. 270-278
-
-
Lai, J.C.1
Brown, B.D.2
Voskresenskiy, A.M.3
Vonhoff, S.4
Klussman, S.5
Tan, W.6
Colombini, M.7
Weeratna, R.8
Miller, P.9
Benimetskaya, L.10
Stein, C.A.11
-
37
-
-
74249112787
-
Therapeutic silencing of micro-RNA-122 in Primates with chronic hepatitis C virus infection
-
LANFORD, R., HILDEBRANDT-ERIKSEN, E. S., PETRI, A., PERSSON, R., LINDOW, M., MUNK, M. E., KAUPPINEN, S., and ØRUM, H. (2010). Therapeutic silencing of micro-RNA-122 in Primates with chronic hepatitis C virus infection. Science 327, 198-201.
-
(2010)
Science
, vol.327
, pp. 198-201
-
-
Lanford, R.1
Hildebrandt-Eriksen, E.S.2
Petri, A.3
Persson, R.4
Lindow, M.5
Munk, M.E.6
Kauppinen, S.7
Ørum, H.8
-
38
-
-
79959223747
-
Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site
-
LAXTON, C., BRADY, K., MOSCHOS, S., TURNPENNY, P., RAWAL, J., PRYDE, D. C., SIDDERS, B., CORBAU, R., PICKFORD, C., and MURRAY, E. J. (2011). Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site. Antimicrob. Agents Chemother. 55, 3105-3114.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 3105-3114
-
-
Laxton, C.1
Brady, K.2
Moschos, S.3
Turnpenny, P.4
Rawal, J.5
Pryde, D.C.6
Sidders, B.7
Corbau, R.8
Pickford, C.9
Murray, E.J.10
-
39
-
-
0034601112
-
Cellular delivery of antisense oligonucleotides
-
LEBEDEVA, I., BENIMETSKAYA, L., STEIN, C. A., and VILENCHIK, M. (2000). Cellular delivery of antisense oligonucleotides. Eur. J. Pharm. Biopharm. 50, 101-119.
-
(2000)
Eur. J. Pharm. Biopharm.
, vol.50
, pp. 101-119
-
-
Lebedeva, I.1
Benimetskaya, L.2
Stein, C.A.3
Vilenchik, M.4
-
40
-
-
84856517940
-
PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates
-
LINDHOLM, M. W., ELMEN, J., FISKER, N., HANSEN, H. F., PERSSON, R., MOLLER, M. R., ROSENBOHM, C., ORUM, H., STRAARUP, E. M., and KOCH, T. (2011). PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates. Mol. Ther. 20, 376-381.
-
(2011)
Mol. Ther.
, vol.20
, pp. 376-381
-
-
Lindholm, M.W.1
Elmen, J.2
Fisker, N.3
Hansen, H.F.4
Persson, R.5
Moller, M.R.6
Rosenbohm, C.7
Orum, H.8
Straarup, E.M.9
Koch, T.10
-
41
-
-
0029099305
-
Ein neuer zugang zu 2-O-alkylribonucleosiden und eigenschaften deren oligonucleotiden
-
MARTIN, P. (1995). Ein neuer zugang zu 2-O-alkylribonucleosiden und eigenschaften deren oligonucleotiden. Helvetica Chimica Acta 78, 486-504.
-
(1995)
Helvetica Chimica Acta
, vol.78
, pp. 486-504
-
-
Martin, P.1
-
42
-
-
33745645838
-
T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB
-
MAX, K. E., ZEEB, M., BIENERT, R., BALBACH, J., and HEINEMANN, U. (2006). T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB. J. Mol. Biol. 360, 702-714.
-
(2006)
J. Mol. Biol.
, vol.360
, pp. 702-714
-
-
Max, K.E.1
Zeeb, M.2
Bienert, R.3
Balbach, J.4
Heinemann, U.5
-
43
-
-
82955233645
-
Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense
-
MOSCHOS, S. A., FRICK, M., TAYLOR, B., TURNPENNY, P., GRAVES, H., SPINK, K. G., BRADY, K., LAMB, D., COLLINS, D., ROCKEL, T. D., et al. (2011). Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol. Ther. 19, 2163-2168.
-
(2011)
Mol. Ther.
, vol.19
, pp. 2163-2168
-
-
Moschos, S.A.1
Frick, M.2
Taylor, B.3
Turnpenny, P.4
Graves, H.5
Spink, K.G.6
Brady, K.7
Lamb, D.8
Collins, D.9
Rockel, T.D.10
-
44
-
-
0041806640
-
Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations
-
MUZET, N., GUILLOT, B., JELSCH, C., HOWARD, E., and LECOMTE, C. (2003). Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations. Proc. Natl. Acad. Sci. U. S. A. 100, 8742-8747.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8742-8747
-
-
Muzet, N.1
Guillot, B.2
Jelsch, C.3
Howard, E.4
Lecomte, C.5
-
45
-
-
0034023314
-
Solution structure of an LNA hybridized to DNA: NMR study of the d(CT(L)GCT(L)T(L)CT(L)GC):d(GCA GAAGCAG) duplex containing four locked nucleotides
-
NIELSEN, K. E., SINGH, S. K., WENGEL, J., and JACOBSEN, J. P. (2000). Solution structure of an LNA hybridized to DNA: NMR study of the d(CT(L)GCT(L)T(L)CT(L)GC):d(GCA GAAGCAG) duplex containing four locked nucleotides. Bioconjug. Chem. 11, 228-238.
-
(2000)
Bioconjug. Chem.
, vol.11
, pp. 228-238
-
-
Nielsen, K.E.1
Singh, S.K.2
Wengel, J.3
Jacobsen, J.P.4
-
46
-
-
27544483499
-
The structure of a mixed LNA/DNA:RNA duplex is driven by conformational coupling between LNA and deoxyribose residues as determined from (13)C relaxation measurements
-
NIELSEN, K. E., and SPIELMANN, H. P. (2005). The structure of a mixed LNA/DNA:RNA duplex is driven by conformational coupling between LNA and deoxyribose residues as determined from (13)C relaxation measurements. J. Am. Chem. Soc. 127, 15273-15282.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 15273-15282
-
-
Nielsen, K.E.1
Spielmann, H.P.2
-
47
-
-
0026341239
-
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
-
NIELSEN, P. E., EGHOLM, M., BERG, R. H., and BUCHARDT, O. (1991). Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500.
-
(1991)
Science
, vol.254
, pp. 1497-1500
-
-
Nielsen, P.E.1
Egholm, M.2
Berg, R.H.3
Buchardt, O.4
-
48
-
-
79953202455
-
Silencing of microRNA families by seed-targeting tiny LNAs
-
OBAD, S., DOS SANTOS, C. O., PETRI, A., HEIDENBLAD, M., BROOM, O., RUSE, C., FU, C., LINDOW, M., STENVANG, J., STRAARUP, E. M., et al. (2011). Silencing of microRNA families by seed-targeting tiny LNAs. Nat. Genet. 43, 371-378.
-
(2011)
Nat. Genet.
, vol.43
, pp. 371-378
-
-
Obad, S.1
Dos Santos, C.O.2
Petri, A.3
Heidenblad, M.4
Broom, O.5
Ruse, C.6
Lindow, M.7
Stenvang, J.8
Straarup, E.M.9
-
49
-
-
0030862285
-
Synthesis of 2-0,4-C-methyleneuridine and-cytidine
-
OBIKA, S., NANBU, D., HARI, Y., MORIO, J. A. K., IN, Y., ISHIDA, T., and IMANISHI, T. (1997). Synthesis of 2-0,4-C-methyleneuridine and-cytidine. Novel bicyclic nucleosides having a fixed c3-endo sugar puckering. Tetrahedron Lett. 38, 8735-8738.
-
(1997)
Novel Bicyclic Nucleosides Having A Fixed c3-endo Sugar Puckering. Tetrahedron Lett.
, vol.38
, pp. 8735-8738
-
-
Obika, S.1
Nanbu, D.2
Hari, Y.3
Morio, J.A.K.4
Ishida, T.5
Imanishi, T.6
-
50
-
-
0037140761
-
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids
-
PETERSEN, M., BONDENSGAARD, K., WENGEL, J., and JACOBSEN, J. P. (2002). Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. J. Am. Chem. Soc. 124, 5974-5982.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5974-5982
-
-
Petersen, M.1
Bondensgaard, K.2
Wengel, J.3
Jacobsen, J.P.4
-
51
-
-
17344376224
-
The conformations of locked nucleic acids (LNA)
-
PETERSEN, M., NIELSEN, C. B., NIELSEN, K. E., JENSEN, G. A., BONDENSGAARD, K., SINGH, S. K., RAJWANSHI, V. K., KOSHKIN, A. A., DAHL, B. M., WENGEL, J., and JACOBSEN, J. P. (2000). The conformations of locked nucleic acids (LNA). J. Mol. Recognit. 13, 44-53.
-
(2000)
J. Mol. Recognit.
, vol.13
, pp. 44-53
-
-
Petersen, M.1
Nielsen, C.B.2
Nielsen, K.E.3
Jensen, G.A.4
Bondensgaard, K.5
Singh, S.K.6
Rajwanshi, V.K.7
Koshkin, A.A.8
Dahl, B.M.9
Wengel, J.10
Jacobsen, J.P.11
-
52
-
-
0036771786
-
2-O-[2-(methylthio) ethyl]-modified oligonucleotide: An analogue of 2-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA
-
PRAKASH, T. P., MANOHARAN, M., KAWASAKI, A. M., FRASER, A. S., LESNIK, E. A., SIOUFI, N., LEEDS, J. M., TEPLOVA, M., and EGLI, M. (2002). 2-O-[2-(methylthio) ethyl]-modified oligonucleotide: an analogue of 2-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA. Biochemistry 41, 11642-11648.
-
(2002)
Biochemistry
, vol.41
, pp. 11642-11648
-
-
Prakash, T.P.1
Manoharan, M.2
Kawasaki, A.M.3
Fraser, A.S.4
Lesnik, E.A.5
Sioufi, N.6
Leeds, J.M.7
Teplova, M.8
Egli, M.9
-
53
-
-
59449093219
-
Short antisense oligonucleotides with novel 2-4 conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals
-
SETH, P. P., SIWKOWSKI, A., ALLERSON, C. R., VASQUEZ, G., LEE, S., PRAKASH, T. P., WANCEWICZ, E. V., WITCHELL, D., and SWAYZE, E. E. (2009). Short antisense oligonucleotides with novel 2-4 conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals. J. Med. Chem. 52, 10-13.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 10-13
-
-
Seth, P.P.1
Siwkowski, A.2
Allerson, C.R.3
Vasquez, G.4
Lee, S.5
Prakash, T.P.6
Wancewicz, E.V.7
Witchell, D.8
Swayze, E.E.9
-
54
-
-
0003900439
-
-
VCH: Weinheim, Germany
-
SHABAROVA, Z. A., Bogdanov, A. A. (1994). Advanced organic chemistry of nucleic acids, (VCH: Weinheim, Germany), pp. 389-471.
-
(1994)
Advanced Organic Chemistry of Nucleic Acids
, pp. 389-471
-
-
Shabarova, Z.A.1
Bogdanov, A.A.2
-
55
-
-
0034039797
-
Electrostatic aspects of protein-protein interactions
-
SHEINERMAN, F. B., NOREL, R., and HONIG, B. (2000). Electrostatic aspects of protein-protein interactions. Curr. Opin. Struct. Biol. 10, 153-159.
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 153-159
-
-
Sheinerman, F.B.1
Norel, R.2
Honig, B.3
-
56
-
-
0343065617
-
LNA (locked nucleic acids): Synthesis and highaffinity nucleic acid recognition
-
SINGH, S. K., NIELSEN, P., KOSHKIN, A., and WENGEL, J. (1998). LNA (locked nucleic acids): synthesis and highaffinity nucleic acid recognition. Chem. Commun. 455-456.
-
(1998)
Chem. Commun.
, pp. 455-456
-
-
Singh, S.K.1
Nielsen, P.2
Koshkin, A.3
Wengel, J.4
-
57
-
-
84555187851
-
Silencing of gene expression by gymnotic delivery of antisense oligonucleotides
-
SOIFER, H. S., KOCH, T., LAI, J., HANSEN, B., HOEG, A., OERUM, H., and STEIN, C. A. (2012). Silencing of gene expression by gymnotic delivery of antisense oligonucleotides. Methods Mol. Biol. 815, 333-346.
-
(2012)
Methods Mol. Biol.
, vol.815
, pp. 333-346
-
-
Soifer, H.S.1
Koch, T.2
Lai, J.3
Hansen, B.4
Hoeg, A.5
Oerum, H.6
Stein, C.A.7
-
58
-
-
84870197940
-
Chemical modification study of antisense gapmers
-
STANTON, R., SCIABOLA, S., SALATTO, C., WENG, Y., MOSHINSKY, D., LITTLE, J., WALTERS, E., KREEGER, J., DIMATTIA, D., CHEN, T., et al. (2012). Chemical modification study of antisense gapmers. Nucleic Acid Ther. 22, 344-359.
-
(2012)
Nucleic Acid Ther.
, vol.22
, pp. 344-359
-
-
Stanton, R.1
Sciabola, S.2
Salatto, C.3
Weng, Y.4
Moshinsky, D.5
Little, J.6
Walters, E.7
Kreeger, J.8
Dimattia, D.9
Chen, T.10
-
59
-
-
75649138331
-
Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
-
STEIN, C. A., HANSEN, J. B., LAI, J., WU, S., VOSKRESENSKIY, A., HOG, A., WORM, J., HEDTJARN, M., SOULEIMANIAN, N., MILLER, P., SOIFER, H. S., et al. (2010). Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents. Nucleic Acids Res. 38, e3.
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Stein, C.A.1
Hansen, J.B.2
Lai, J.3
Voskresenskiy, A.4
Hog, A.5
Worm, J.6
Hedtjarn, M.7
Souleimanian, N.8
Miller, P.9
Soifer, H.S.10
-
60
-
-
65249087358
-
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
-
STEIN, C. A., WU, S., VOSKRESENSKIY, A. M., ZHOU, J. F., SHIN, J., MILLER, P., SOULEIMANIAN, N., and BENIMETSKAYA, L. (2009). G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis. Clin. Cancer Res. 15, 2797-2807.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2797-2807
-
-
Stein, C.A.1
Voskresenskiy, A.M.2
Zhou, J.F.3
Shin, J.4
Miller, P.5
Souleimanian, N.6
Benimetskaya, L.7
-
61
-
-
78649877710
-
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
-
STRAARUP, E. M., FISKER, N., HEDTJARN, M., LINDHOLM, M. W., ROSENBOHM, C., AARUP, V., HANSEN, H. F., ORUM, H., HANSEN, J. B., and KOCH, T. (2010). Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res. 38, 7100-7111.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7100-7111
-
-
Straarup, E.M.1
Fisker, N.2
Hedtjarn, M.3
Lindholm, M.W.4
Rosenbohm, C.5
Aarup, V.6
Hansen, H.F.7
Orum, H.8
Hansen, J.B.9
Koch, T.10
-
62
-
-
0038298792
-
Profiling charge complementarity and selectivity for binding at the protein surface
-
SULEA, T., and PURISIMA, E. O. (2003). Profiling charge complementarity and selectivity for binding at the protein surface. Biophys. J. 84, 2883-2896.
-
(2003)
Biophys. J.
, vol.84
, pp. 2883-2896
-
-
Sulea, T.1
Purisima, E.O.2
-
63
-
-
0037423272
-
Biochemical characterization of interactions between DNA polymerase and singlestranded DNA-binding protein in bacteriophage RB69
-
SUN, S., and SHAMOO, Y. (2003). Biochemical characterization of interactions between DNA polymerase and singlestranded DNA-binding protein in bacteriophage RB69. J. Biol. Chem. 278, 3876-3881.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3876-3881
-
-
Sun, S.1
Shamoo, Y.2
-
64
-
-
0028533867
-
Triplex formation at single-stranded nucleic acid target sites of unrestricted sequences by two added strands of oligonucleotides: A proposed model
-
TRAPANE, T., and TS'O, P. (1994). Triplex formation at single-stranded nucleic acid target sites of unrestricted sequences by two added strands of oligonucleotides: a proposed model. J. Am. Chem. Soc. 116, 10437-10449.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 10437-10449
-
-
Trapane, T.1
Ts'o, P.2
-
65
-
-
0034002916
-
Recent advances in the medicinal chemistry of antisense oligonucleotides
-
UHLMANN, E. (2000). Recent advances in the medicinal chemistry of antisense oligonucleotides. Curr. Opin. Drug Discov. Devel. 3, 203-213.
-
(2000)
Curr. Opin. Drug Discov. Devel.
, vol.3
, pp. 203-213
-
-
Uhlmann, E.1
-
66
-
-
11944267365
-
Antisense oligonucleotides: A new therapeutic principle
-
UHLMANN, E., and PEYMAN, A. (1990). Antisense oligonucleotides: a new therapeutic principle. Chem. Rev. 90, 544-579.
-
(1990)
Chem. Rev.
, vol.90
, pp. 544-579
-
-
Uhlmann, E.1
Peyman, A.2
-
67
-
-
0034625010
-
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
-
WAHLESTEDT, C., SALMI, P., GOOD, L., KELA, J., JOHNSSON, T., HOKFELT, T., BROBERGER, C., PORRECA, F., LAI, J., REN, K., et al. (2000). Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc. Natl. Acad. Sci. U. S. A 97, 5633-5638.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A
, vol.97
, pp. 5633-5638
-
-
Wahlestedt, C.1
Salmi, P.2
Good, L.3
Kela, J.4
Johnsson, T.5
Hokfelt, T.6
Broberger, C.7
Porreca, F.8
Lai, J.9
Ren, K.10
-
68
-
-
33745213356
-
Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302)
-
WATANABE, T. A., GEARY, R. S., and LEVIN, A. A. (2006). Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302). Oligonucleotides 16, 169-180.
-
(2006)
Oligonucleotides
, vol.16
, pp. 169-180
-
-
Watanabe, T.A.1
Geary, R.S.2
Levin, A.A.3
-
69
-
-
0038497542
-
A structure of deoxyribose nucleic acid
-
WATSON, J. D., and CRICK, F. H. C. (1953a). A structure of deoxyribose nucleic acid. Nature 171, 737-738.
-
(1953)
Nature
, vol.171
, pp. 737-738
-
-
Watson, J.D.1
Crick, F.H.C.2
-
70
-
-
33749048664
-
Genetical implications of the structure of deoxyribonucleic acid
-
WATSON, J. D., and CRICK, F. H. C. (1953b). Genetical implications of the structure of deoxyribonucleic acid. Nature 171, 964-967.
-
(1953)
Nature
, vol.171
, pp. 964-967
-
-
Watson, J.D.1
Crick, F.H.C.2
-
72
-
-
79953254828
-
Antisense drug discovery and development
-
YAMAMOTO, T., NAKATANI, M., NARUKAWA, K., and OBIKA, S. (2011). Antisense drug discovery and development. Future Med. Chem. 3, 339-365.
-
(2011)
Future Med. Chem.
, vol.3
, pp. 339-365
-
-
Yamamoto, T.1
Nakatani, M.2
Narukawa, K.3
Obika, S.4
-
73
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligonucleotide
-
ZAMECNIK, P. C., and STEPHENSON, M. L. (1978). Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligonucleotide. Proc. Natl. Acad. Sci. U. S. A. 75, 280-284.
-
(1978)
Proc. Natl. Acad. Sci. U. S. A.
, vol.75
, pp. 280-284
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
74
-
-
33750008214
-
Recognition of T-rich singlestranded DNA by the cold shock protein Bs-CspB in solution
-
ZEEB, M., MAX, K. E., WEININGER, U., LOW, C., STICHT, H., and BALBACH, J. (2006). Recognition of T-rich singlestranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res. 34, 4561-4571.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 4561-4571
-
-
Zeeb, M.1
Max, K.E.2
Weininger, U.3
Low, C.4
Sticht, H.5
Balbach, J.6
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