Cardiovascular complications of sleep apnea: Role of oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn 2014, Issue , 2014, Pages

  Badran, Mohammad ^a   Ayas, Najib ^b   Laher, Ismail ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; OXIDATIVE STRESS;

CARDIO-VASCULAR DISEASE; CELLULAR MECHANISMS; ENDOTHELIAL DYSFUNCTION; HUMAN PATIENTS; INTERMITTENT HYPOXIAS; OBSTRUCTIVE SLEEP APNEA; PATHOPHYSIOLOGICAL; REACTIVE OXYGEN SPECIES;

SLEEP RESEARCH;

REACTIVE OXYGEN METABOLITE;

ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CORONARY ARTERY DISEASE; ENDOTHELIAL DYSFUNCTION; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; HYPERTENSION; INTERMITTENT HYPOXIA; OXIDATIVE STRESS; SLEEP DISORDERED BREATHING; BIOLOGICAL MODEL; CARDIOVASCULAR DISEASES; COMPLICATION; PATHOLOGY;

CARDIOVASCULAR DISEASES; HUMANS; MODELS, BIOLOGICAL; OXIDATIVE STRESS; SLEEP APNEA SYNDROMES;

EID: 84896969402     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2014/985258     Document Type: Article

References (94)

1. Golbidi S., Badran M., Ayas N., Laher I., Cardiovascular consequences of sleep apnea. Lung 2012 190 113 132 2-s2.0-80055034226 10.1007/s00408-011-9340-1
2. Young T., Peppard P. E., Gottlieb D. J., Epidemiology of obstructive sleep apnea: a population health perspective. American Journal of Respiratory and Critical Care Medicine 2002 165 9 1217 1239 2-s2.0-0036569980 10.1164/rccm.2109080 (Pubitemid 34461732)
3. Redline S., Tishler P. V., Schluchter M., Aylor J., Clark K., Graham G., Risk factors for sleep-disordered breathing in children: qassociations with obesity, race, and respiratory problems. American Journal of Respiratory and Critical Care Medicine 1999 159 5 1527 1532 2-s2.0-0032957882 (Pubitemid 29227864)
4. Peppard P. E., Young T., Palta M., Skatrud J., Prospective study of the association between sleep-disordered breathing and hypertension. The New England Journal of Medicine 2000 342 19 1378 1384 2-s2.0-0034636477 10.1056/NEJM200005113421901 (Pubitemid 30262394)
5. Gottlieb D. J., Yenokyan G., Newman A. B., O'Connor G. T., Punjabi N. M., Quan S. F., Redline S., Resnick H. E., Tong E. K., Diener-West M., Shahar E., Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 2010 122 4 352 360 2-s2.0-77955171749 10.1161/CIRCULATIONAHA.109.901801
6. Arzt M., Young T., Finn L., Skatrud J. B., Bradley T. D., Association of sleep-disordered breathing and the occurrence of stroke. American Journal of Respiratory and Critical Care Medicine 2005 172 11 1447 1451 2-s2.0-30344467816 10.1164/rccm.200505-702OC (Pubitemid 43069819)
7. Gami A. S., Hodge D. O., Herges R. M., Olson E. J., Nykodym J., Kara T., Somers V. K., Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. Journal of the American College of Cardiology 2007 49 5 565 571 2-s2.0-33846613643 10.1016/j.jacc.2006.08.060 (Pubitemid 46177437)
8. Liu J.-N., Zhang J.-X., Lu G., Qiu Y., Yang D., Yin G.-Y., Zhang X.-L., The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia. Chinese Medical Journal 2010 123 1 74 78 2-s2.0-74749103367 10.3760/cma.j.issn.0366-6999.2010.01.013
9. Jun J., Reinke C., Bedja D., Berkowitz D., Bevans-Fonti S., Li J., Barouch L. A., Gabrielson K., Polotsky V. Y., Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 2010 209 2 381 386 2-s2.0-77950020024 10.1016/j.atherosclerosis.2009.10.017
10. Park A.-M., Suzuki Y. J., Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. Journal of Applied Physiology 2007 102 5 1806 1814 2-s2.0-34247866246 10.1152/japplphysiol.01291.2006 (Pubitemid 46701948)
11. Rosa D. P., Martinez D., Picada J. N., Semedo J. G., Marroni N. P., Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure. Comparative Hepatology 2011 10, article 1 2-s2.0-79959818879 10.1186/1476-5926-10-1
12. Matsumoto C., Hayashi T., Kitada K., Yamashita C., Miyamura M., Mori T., Ukimura A., Ohkita M., Jin D., Takai S., Miyazaki M., Okada Y., Kitaura Y., Matsumura Y., Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice. Hypertension 2009 54 1 164 171 2-s2.0-67649881400 10.1161/HYPERTENSIONAHA.109.131391
13. Brindeiro C. M. T., Da Silva A. Q., Allahdadi K. J., Youngblood V., Kanagy N. L., Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. American Journal of Physiology: Heart and Circulatory Physiology 2007 293 5 H2971 H2976 2-s2.0-36148987611 10.1152/ajpheart.00219.2007 (Pubitemid 350106521)
14. Hui-guo L., Kui L., Yan-ning Z., Yong-jian X., Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia. Sleep Medicine 2010 11 2 205 212 2-s2.0-75449093386 10.1016/j.sleep.2009.05.015
15. Tufik S., Santos-Silva R., Taddei J. A., Bittencourt L. R. A., Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Medicine 2010 11 5 441 446 2-s2.0-77951648526 10.1016/j.sleep.2009.10.005
16. Kapur V. K., Obstructive sleep apnea: diagnosis, epidemiology, and economics. Respiratory Care 2010 55 9 1155 1167 2-s2.0-77957919124
17. Silverberg D. S., Oksenberg A., Laina A., Sleep-related breathing disorders as a major cause of essential hypertension: fact or fiction? Current Opinion in Nephrology and Hypertension 1998 7 4 353 357 2-s2.0-0031829459 10.1097/00041552-199807000-00001 (Pubitemid 28341744)
18. Sjöström C., Lindberg E., Elmasry A., Hägg A., Svärdsudd K., Janson C., Prevalence of sleep apnoea and snoring in hypertensive men: a population based study. Thorax 2002 57 7 602 607 2-s2.0-0036310880 10.1136/thorax.57.7.602 (Pubitemid 34761762)
19. O'Connor G. T., Caffo B., Newman A. B., Quan S. F., Rapoport D. M., Redline S., Resnick H. E., Samet J., Shahar E., Prospective study of sleep-disordered breathing and hypertension: the sleep heart health study. American Journal of Respiratory and Critical Care Medicine 2009 179 12 1159 1164 2-s2.0-67449093751 10.1164/rccm.200712-1809OC
20. Pedrosa R. P., Drager L. F., Gonzaga C. C., Sousa M. G., De Paula L. K. G., Amaro A. C. S., Amodeo C., Bortolotto L. A., Krieger E. M., Bradley T. D., Lorenzi-Filho G., Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension 2011 58 5 811 817 2-s2.0-83155180378 10.1161/HYPERTENSIONAHA.111.179788
21. Chobanian A. V., Bakris G. L., Black H. R., Cushman W. C., Green L. A., Izzo J. L. Jr., Jones D. W., Materson B. J., Oparil S., Wright J. T. Jr., Roccella E. J., Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003 42 6 1206 1252 2-s2.0-0347423198 10.1161/01.HYP.0000107251.49515.c2 (Pubitemid 37553153)
22. Becker H. F., Jerrentrup A., Ploch T., Grote L., Penzel T., Sullivan C. E., Peter J. H., Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 2003 107 1 68 73 2-s2.0-0037422591 10.1161/01.CIR.0000042706.47107.7A (Pubitemid 36070935)
23. Peker Y., Kraiczi H., Hedner J., Löth S., Johansson A., Bende M., An independent association between obstructive sleep apnoea and coronary artery disease. European Respiratory Journal 1999 14 1 179 184 2-s2.0-0032866064 10.1034/j.1399-3003.1999.14a30.x (Pubitemid 29411254)
24. Konecny T., Sert Kuniyoshi F. H., Orban M., Pressman G. S., Kara T., Gami A., Caples S. M., Lopez-Jimenez F., Somers V. K., Under-diagnosis of sleep apnea in patients after acute myocardial infarction. Journal of the American College of Cardiology 2010 56 9 742 743 2-s2.0-77955889788 10.1016/j.jacc.2010. 04.032
25. Sorajja D., Gami A. S., Somers V. K., Behrenbeck T. R., Garcia-Touchard A., Lopez-Jimenez F., Independent association between obstructive sleep apnea and subclinical coronary artery disease. Chest 2008 133 4 927 933 2-s2.0-42149171750 10.1378/chest.07-2544 (Pubitemid 351536868)
26. Gami A. S., Rader S., Svatikova A., Wolk R., Herold D. L., Huyber C., Winnicki M., Somers V. K., Familial premature coronary artery disease mortality and obstructive sleep apnea. Chest 2007 131 1 118 121 2-s2.0-33846304207 10.1378/chest.06-1404 (Pubitemid 46122982)
27. Kaneko Y., Hajek V. E., Zivanovic V., Raboud J., Bradley T. D., Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep 2003 26 3 293 297 2-s2.0-0042853169 (Pubitemid 39610676)
28. Shahar E., Whitney C. W., Redline S., Lee E. T., Newman A. B., Javler F., George N., O'Connor T., Boland L. L., Schwartz J. E., Samet J. M., Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the sleep heart health study. American Journal of Respiratory and Critical Care Medicine 2001 163 1 19 25 2-s2.0-0035148723 (Pubitemid 32095247)
29. Valham F., Mooe T., Rabben T., Stenlund H., Wiklund U., Franklin K. A., Increased risk of stroke in patients with coronary artery disease and sleep apnea: a 10-year follow-up. Circulation 2008 118 9 955 960 2-s2.0-52049113931 10.1161/CIRCULATIONAHA.108.783290
30. Redline S., Yenokyan G., Gottlieb D. J., Shahar E., O'Connor G. T., Resnick H. E., Diener-West M., Sanders M. H., Wolf P. A., Geraghty E. M., Ali T., Lebowitz M., Punjabi N. M., Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. American Journal of Respiratory and Critical Care Medicine 2010 182 2 269 277 2-s2.0-77954528745 10.1164/rccm.200911-1746OC
31. Shamsuzzaman A. S. M., Gersh B. J., Somers V. K., Obstructive sleep apnea: implications for cardiac and vascular disease. The Journal of the American Medical Association 2003 290 14 1906 1914 2-s2.0-0141922797 10.1001/jama.290.14.1906 (Pubitemid 37430608)
32. Vazir A., Hastings P. C., Dayer M., McIntyre H. F., Henein M. Y., Poole-Wilson P. A., Cowie M. R., Morrell M. J., Simonds A. K., A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction. European Journal of Heart Failure 2007 9 3 243 250 2-s2.0-33847286426 10.1016/j.ejheart.2006.08.001 (Pubitemid 46330138)
33. Yumino D., Wang H., Floras J. S., Newton G. E., Mak S., Ruttanaumpawan P., Parker J. D., Bradley T. D., Prevalence and physiological predictors of sleep apnea in patients with heart failure and systolic dysfunction. Journal of Cardiac Failure 2009 15 4 279 285 2-s2.0-65249085038 10.1016/j.cardfail.2008.11. 015
34. Wang H., Parker J. D., Newton G. E., Floras J. S., Mak S., Chiu K.-L., Ruttanaumpawan P., Tomlinson G., Bradley T. D., Influence of obstructive sleep apnea on mortality in patients with heart failure. Journal of the American College of Cardiology 2007 49 15 1625 1631 2-s2.0-34047257334 10.1016/j.jacc.2006.12.046 (Pubitemid 46551635)
35. Marin J. M., Carrizo S. J., Vicente E., Agusti A. G. N., Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. The Lancet 2005 365 9464 1046 1053 2-s2.0-15244344823 10.1016/S0140-6736(05)71141-7 (Pubitemid 40386782)
36. Valko M., Leibfritz D., Moncol J., Cronin M. T. D., Mazur M., Telser J., Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology 2007 39 1 44 84 2-s2.0-33749986298 10.1016/j.biocel.2006.07.001 (Pubitemid 44566469)
37. Halliwell B., Reactive oxygen species in living systems: source, biochemistry, and role in human disease. American Journal of Medicine 1991 91 3 14S 22S 2-s2.0-4244087065
38. Beckman J. S., Koppenol W. H., Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. American Journal of Physiology: Cell Physiology 1996 271 5 C1424 C1437 2-s2.0-0029805172
39. Babior B. M., Phagocytes and oxidative stress. American Journal of Medicine 2000 109 1 33 44 2-s2.0-0034725724 10.1016/S0002-9343(00)00481-2 (Pubitemid 30608735)
40. Mohazzab K. M., Kaminski P. M., Wolin M. S., NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. American Journal of Physiology: Heart and Circulatory Physiology 1994 266 6 H2568 H2572 2-s2.0-0028233138 (Pubitemid 24215893)
41. Griendling K. K., Sorescu D., Ushio-Fukai M., NAD(P)H oxidase: role in cardiovascular biology and disease. Circulation Research 2000 86 5 494 501 2-s2.0-0034677947 (Pubitemid 30165039)
42. Schulz R., Mahmoudi S., Hattar K., Sibelius U. L. F., Olschewski H., Mayer K., Seeger W., Grimminger F., Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea: impact of continuous positive airway pressure therapy. American Journal of Respiratory and Critical Care Medicine 2000 162 2 566 570 2-s2.0-0033845075 (Pubitemid 30647201)
43. Dyugovskaya L., Lavie P., Lavie L., Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. American Journal of Respiratory and Critical Care Medicine 2002 165 7 934 939 2-s2.0-0036528981 (Pubitemid 34774660)
44. Dyugovskaya L., Polyakov A., Lavie P., Lavie L., Delayed neutrophil apoptosis in patients with sleep apnea. American Journal of Respiratory and Critical Care Medicine 2008 177 5 544 554 2-s2.0-40649097290 10.1164/rccm.200705-675OC (Pubitemid 351442194)
45. Lavie L., Vishnevsky A., Lavie P., Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004 27 1 123 128 2-s2.0-2442674412 (Pubitemid 43906323)
46. Barcelo A., Miralles C., Barbe F., Vila M., Pons S., Agusti A. G. N., Abnormal lipid peroxidation in patients with sleep apnoea. European Respiratory Journal 2000 16 4 644 647 2-s2.0-0033777033 10.1034/j.1399-3003.2000.16d13.x
47. Kizawa T., Nakamura Y., Takahashi S., Sakurai S., Yamauchi K., Inoue H., Pathogenic role of angiotensin II and oxidised LDL in obstructive sleep apnoea. European Respiratory Journal 2009 34 6 1390 1398 2-s2.0-73249133165 10.1183/09031936.00009709
48. Vatansever E., Surmen-Gur E., Ursavas A., Karadag M., Obstructive sleep apnea causes oxidative damage to plasma lipids and proteins and decreases adiponectin levels. Sleep and Breathing 2011 15 3 275 282 2-s2.0-80054929356 10.1007/s11325-010-0378-8
49. Yamauchi M., Nakano H., Maekawa J., Okamoto J., Ohnishi Y., Suzuki T., Kimura H., Oxidative stress in obstructive sleep apnea. Chest 2005 127 5 1674 1679 2-s2.0-19844383448 10.1378/chest.127.5.1674 (Pubitemid 46218794)
50. Jelic S., Le Jemtel T. H., Inflammation, oxidative stress, and the vascular endothelium in obstructive sleep apnea. Trends in Cardiovascular Medicine 2008 18 7 253 260 2-s2.0-60149084225 10.1016/j.tcm.2008.11.008
51. Christou K., Moulas A. N., Pastaka C., Gourgoulianis K. I., Antioxidant capacity in obstructive sleep apnea patients. Sleep Medicine 2003 4 3 225 228 2-s2.0-0038676909 10.1016/S1389-9457(02)00253-8 (Pubitemid 36748608)
52. Barceló A., Barbé F., de la Peña M., Vila M., Pérez G., Piérola J., Durán J., Agustí A. G. N., Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment. European Respiratory Journal 2006 27 4 756 760 2-s2.0-33750117317 10.1183/09031936.06.00067605 (Pubitemid 44914199)
53. Katsoulis K., Kontakiotis T., Spanogiannis D., Vlachogiannis E., Kougioulis M., Gerou S., Daskalopoulou E., Total antioxidant status in patients with obstructive sleep apnea without comorbidities: the role of the severity of the disease. Sleep and Breathing 2011 15 4 861 866 2-s2.0-84859385971 10.1007/s11325-010-0456-y
54. Hendricks J. C., Kline L. R., Kovalski R. J., O'Brien J. A., Morrison A. R., Pack A. I., The English bulldog: a natural model of sleep-disordered breathing. Journal of Applied Physiology 1987 63 4 1344 1350 2-s2.0-0023549870 (Pubitemid 18024166)
55. van Lunteren E., Effects of genetic obesity on rat upper airway muscle and diaphragm contractile properties. European Respiratory Journal 1996 9 10 2139 2144 2-s2.0-0029784903 (Pubitemid 26333557)
56. Alonso-Galicia M., Brands M. W., Zappe D. H., Hall J. E., Hypertension in obese Zucker rats: role of angiotensin II and adrenergic activity. Hypertension 1996 28 6 1047 1054 2-s2.0-0029808766 (Pubitemid 26415823)
57. Fredersdorf S., Thumann C., Ulucan C., Griese D. P., Luchner A., Riegger G. A. J., Kromer E. P., Weil J., Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats. Cardiovascular Pathology 2004 13 1 11 19 2-s2.0-0842283309 10.1016/S1054-8807(03)00109-1 (Pubitemid 38169461)
58. Lee S.-D., Nakano H., Farkas G. A., Adenosinergic modulation of ventilation in obese zucker rats. Obesity Research 2005 13 3 545 555 2-s2.0-22844441436
59. Radulovacki M., Trbovic S., Carley D. W., Hypotension reduces sleep apneas in Zucker lean and Zucker obese rats. Sleep 1996 19 10 767 773 2-s2.0-0030433707 (Pubitemid 27131926)
60. 2 reserve in sleeping dogs. Journal of Applied Physiology 2007 103 6 1942 1949 2-s2.0-36849016269 10.1152/japplphysiol.00735.2007 (Pubitemid 350232375)
61. Kimoff R. J., Brooks D., Horner R. L., Kozar L. F., Render-Teixeira C. L., Champagne V., Mayer P., Phillipson E. A., Ventilatory and arousal responses to hypoxia and hypercapnia in a canine model of obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 1997 156 3 886 894 2-s2.0-0030783048 (Pubitemid 27396431)
62. Launois S. H., Averill N., Abraham J. H., Kirby D. A., Weiss J. W., Cardiovascular responses to nonrespiratory and respiratory arousals in a porcine model. Journal of Applied Physiology 2001 90 1 114 120 2-s2.0-0035173613 (Pubitemid 32038510)
63. White S. G., Fletcher E. C., Miller C. C. III, Acute systemic blood pressure elevation in obstructive and nonobstructive breath hold in primates. Journal of Applied Physiology 1995 79 1 324 330 2-s2.0-0029135070
64. Farré R., Rotger M., Montserrat J. M., Calero G., Navajas D., Collapsible upper airway segment to study the obstructive sleep apnea/hypopnea syndrome in rats. Respiratory Physiology and Neurobiology 2003 136 2-3 199 209 2-s2.0-0038692881 10.1016/S1569-9048(03)00082-X (Pubitemid 36809007)
65. Nácher M., Serrano-Mollar A., Farré R., Panés J., Seguí J., Montserrat J. M., Recurrent obstructive apneas trigger early systemic inflammation in a rat model of sleep apnea. Respiratory Physiology and Neurobiology 2007 155 1 93 96 2-s2.0-33846022733 10.1016/j.resp.2006.06.004 (Pubitemid 46049132)
66. Schneider H., Schaub C. D., Chen C. A., Andreoni K. A., Schwartz A. R., Smith P. L., Robotham J. L., O'Donnell C. P., Effects of arousal and sleep state on systemic and pulmonary hemodynamics in obstructive apnea. Journal of Applied Physiology 2000 88 3 1084 1092 2-s2.0-0034015977 (Pubitemid 30154915)
67. Tagaito Y., Polotsky V. Y., Campen M. J., Wilson J. A., Balbir A., Smith P. L., Schwartz A. R., O'Donnell C. P., A model of sleep-disordered breathing in the C57BL/6J mouse. Journal of Applied Physiology 2001 91 6 2758 2766 2-s2.0-0035185564 (Pubitemid 33108043)
68. Nisbet R. E., Graves A. S., Kleinhenz D. J., Rupnow H. L., Reed A. L., Fan T.-H. M., Mitchell P. O., Sutliff R. L., Michael Hart C., The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. American Journal of Respiratory Cell and Molecular Biology 2009 40 5 601 609 2-s2.0-65349186285 10.1165/2008-0145OC
69. Jun J., Savransky V., Nanayakkara A., Bevans S., Li J., Smith P. L., Polotsky V. Y., Intermittent hypoxia has organ-specific effects on oxidative stress. American Journal of Physiology: Regulatory Integrative and Comparative Physiology 2008 295 4 R1274 R1281 2-s2.0-57349113972 10.1152/ajpregu.90346.2008
70. Peng Y.-J., Nanduri J., Yuan G., Wang N., Deneris E., Pendyala S., Natarajan V., Kumar G. K., Prabhakar N. R., NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. The Journal of Neuroscience 2009 29 15 4903 4910 2-s2.0-65549160457 10.1523/JNEUROSCI.4768-08.2009
71. Zhan G., Serrano F., Fenik P., Hsu R., Kong L., Pratico D., Klann E., Veasey S. C., NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. American Journal of Respiratory and Critical Care Medicine 2005 172 7 921 929 2-s2.0-25444437443 10.1164/rccm.200504-581OC (Pubitemid 41369078)
72. Savransky V., Bevans S., Nanayakkara A., Li J., Smith P. L., Torbenson M. S., Polotsky V. Y., Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. American Journal of Physiology: Gastrointestinal and Liver Physiology 2007 293 4 G871 G877 2-s2.0-35349013538 10.1152/ajpgi.00145.2007 (Pubitemid 47605939)
73. Xu W., Chi L., Xu R., Ke Y., Luo C., Cai J., Qiu M., Gozal D., Liu R., Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 2005 43 4 204 213 2-s2.0-17444427385 10.1038/sj.sc.3101674 (Pubitemid 40546718)
74. Kato M., Roberts-Thomson P., Phillips B. G., Haynes W. G., Winnicki M., Accurso V., Somers V. K., Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000 102 21 2607 2610 2-s2.0-0034700285
75. Li J., Savransky V., Nanayakkara A., Smith P. L., O'Donnell C. P., Polotsky V. Y., Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. Journal of Applied Physiology 2007 102 2 557 563 2-s2.0-33846882824 10.1152/japplphysiol.01081.2006 (Pubitemid 46220883)
76. Glass C. K., Witztum J. L., Atherosclerosis: the road ahead. Cell 2001 104 4 503 516 2-s2.0-0035936802 10.1016/S0092-8674(01)00238-0 (Pubitemid 32201946)
77. Ip M. S., Lam B., Chan L.-Y., Zheng L., Tsang K. W. T., Fung P. C. W., Lam W.-K., Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. American Journal of Respiratory and Critical Care Medicine 2000 162 6 2166 2171 2-s2.0-0034526576 (Pubitemid 32051681)
78. Teramoto S., Kume H., Matsuse T., Ishii T., Miyashita A., Akishita M., Toba K., Ouchi Y., Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome. Sleep Medicine 2003 4 5 403 407 2-s2.0-0141446377 10.1016/S1389-9457(03)00102-3 (Pubitemid 37193023)
79. Svatikova A., Wolk R., Wang H. H., Otto M. E., Bybee K. A., Singh R. J., Somers V. K., Circulating free nitrotyrosine in obstructive sleep apnea. American Journal of Physiology: Regulatory Integrative and Comparative Physiology 2004 287 2 R284 R287 2-s2.0-3242804406 10.1152/ajpregu.00241.2004 (Pubitemid 38970278)
80. Tabrizi-Fard M. A., Maurer T. S., Fung H.-L., In vivo disposition of 3-nitro-L-tyrosine in rats: implications on tracking systemic peroxynitrite exposure. Drug Metabolism and Disposition 1999 27 4 429 431 2-s2.0-0032950583 (Pubitemid 29177632)
81. Yung L. M., Leung F. P., Yao X., Chen Z.-Y., Huang Y., Reactive oxygen species in vascular wall. Cardiovascular and Hematological Disorders 2006 6 1 1 19 2-s2.0-33744501251 (Pubitemid 43803123)
82. Antoniades C., Shirodaria C., Warrick N., Cai S., De Bono J., Lee J., Leeson P., Neubauer S., Ratnatunga C., Pillai R., Refsum H., Channon K. M., 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 2006 114 11 1193 1201 2-s2.0-33748645122 10.1161/CIRCULATIONAHA.106.612325 (Pubitemid 44386484)
83. Ohike Y., Kozaki K., Iijima K., Eto M., Kojima T., Ohga E., Santa T., Imai K., Hashimoto M., Yoshizumi M., Ouchi Y., Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure: possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circulation Journal 2005 69 2 221 226 2-s2.0-20044370806 10.1253/circj.69.221 (Pubitemid 40313045)
84. Tanaka T., Nakamura H., Yodoi J., Bloom E. T., Redox regulation of the signaling pathways leading to eNOS phosphorylation. Free Radical Biology and Medicine 2005 38 9 1231 1242 2-s2.0-15944406071 10.1016/j.freeradbiomed.2005.01. 002 (Pubitemid 40445540)
85. Alchanatis M., Tourkohoriti G., Kakouros S., Kosmas E., Podaras S., Jordanoglou J. B., Daytime pulmonary hypertension in patients with obstructive sleep apnea: the effect of continuous positive airway pressure on pulmonary hemodynamics. Respiration 2001 68 6 566 572 2-s2.0-0035685436 10.1159/000050574 (Pubitemid 34062928)
86. Hetzel M., Kochs M., Marx N., Woehrle H., Mobarak I., Hombach V., Hetzel J., Pulmonary hemodynamics in obstructive sleep apnea: frequency and causes of pulmonary hypertension. Lung 2003 181 3 157 166 2-s2.0-0041909734 10.1007/s00408-003-1017-y (Pubitemid 37100590)
87. Weitzenblum E., Chaouat A., Obstructive sleep apnea syndrome and the pulmonary circulation. Italian Heart Journal 2005 6 10 795 798 2-s2.0-33644673831
88. Dursunolu N., Dursunolu D., Kiliç M., Impact of obstructive sleep apnea on right ventricular global function: sleep apnea and myocardial performance index. Respiration 2005 72 3 278 284 2-s2.0-22144482398 10.1159/000085369 (Pubitemid 40981087)
89. Otto M. E., Belohlavek M., Romero-Corral A., Gami A. S., Gilman G., Svatikova A., Amin R. S., Lopez-Jimenez F., Khandheria B. K., Somers V. K., Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. American Journal of Cardiology 2007 99 9 1298 1302 2-s2.0-34247548377 10.1016/j.amjcard.2006.12.052 (Pubitemid 46659871)
90. Romero-Corral A., Somers V. K., Pellikka P. A., Olson E. J., Bailey K. R., Korinek J., Orban M., Sierra-Johnson J., Kato M., Amin R. S., Lopez-Jimenez F., Decreased right and left ventricular myocardial performance in obstructive sleep apnea. Chest 2007 132 6 1863 1870 2-s2.0-37549066967 10.1378/chest.07-0966
91. Sajkov D., McEvoy R. D., Obstructive sleep apnea and pulmonary hypertension. Progress in Cardiovascular Diseases 2009 51 5 363 370 2-s2.0-60649085826 10.1016/j.pcad.2008.06.001
92. Suzuki Y. J., Jain V., Park A.-M., Day R. M., Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radical Biology and Medicine 2006 40 10 1683 1692 2-s2.0-33746701376 10.1016/j.freeradbiomed.2006.01.008 (Pubitemid 44308121)
93. Fletcher E. C., Lesske J., Behm R., Miller C. C. III, Stauss H., Unger T., Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. Journal of Applied Physiology 1992 72 5 1978 1984 2-s2.0-0026656461
94. Williams S. E. J., Wootton P., Mason H. S., Bould J., Iles D. E., Riccardi D., Peers C., Kemp P. J., Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 2004 306 5704 2093 2097 2-s2.0-10844248490 10.1126/science.1105010 (Pubitemid 40007661)