Hypotension reduces sleep apneas in Zucker lean and Zucker obese rats

Sleep

Volumn 19, Issue 10, 1996, Pages 767-773

  Radulovacki, Miodrag ^a   Trbovic, Sinisa ^a   Carley, David W ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Hypotension Sleep apneas; Zucker rats

Indexed keywords

HYDRALAZINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MONITORING; BREATHING RATE; CONTROLLED STUDY; HYPOTENSION; LUNG MINUTE VOLUME; MALE; NONHUMAN; NONREM SLEEP; OBESITY; PRIORITY JOURNAL; RAT; REM SLEEP; RESPIRATORY DRIVE; SLEEP APNEA SYNDROME; SLEEP STAGE;

EID: 0030433707     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/19.10.767     Document Type: Article

References (34)

1. Bradley T, Phillipson E. Central sleep apnea. Clin Chest Med 1992;13:493-505.
2. Bradley TD, McNicholas WT, Rutherford R, et al. Clinical and physiological heterogeneity of the central sleep apnea syndrome. Am Rev Respir Dis 1986;134:217-21.
3. Onal E. Central sleep apnea. Semin Respir Med 1988;9:547-53.
4. Kales A, Bixler ED, Cadieux RJ, et al. Sleep apnea in a hypertensive population. Lancet 1984;2:1005-8.
5. Levinson PD, Millman RP. Causes and consequences of blood pressure alterations in obstructive sleep apnea. Arch Intern Med 1991;151:455-62.
6. Peter JH. Modes of selection: epidemiology of sleep apnea. In: Levi-Valensi P, Duron B, eds. Sleep disorders and respiration. Colloque INSERM 1988;168:135-50.
7. Mayer J, Weichler U, Becker H, Penzel T, Peter JH, Wiehert P. Sleep apnea induced changes in blood pressure and heart rate. In: Home J, ed. Sleep '88. Stuttgart: G Fischer Verlag, 1989:270-2.
8. Mayer J, Weichler U, Herres-Mayer B, Schneider H, Marx U, Peter JH. Influence of metoprolol and cilazapril on blood pressure and on sleep apnea activity. J Cardiovasc Pharmacol 1990;16:952-61.
9. Sant' Ambrogio G, Remmers JE. Reflex influences acting on the respiratory muscles of the chest wall. In: Roussos C, Macklem PT, eds. The thorax. (Lung Biol Health Dis Ser). New York: M Dekker, 1985:531-94.
10. Widdicombe JG. Respiratory reflexes: In: Handbook of physiology. Respiration. Washington, DC: American Physiological Society 1964:585-630.
11. Ohtake PJ, Jennings DB. Ventilation is stimulated by small reductions in arterial pressure in the awake dog. J Appl Physiol 1992;73:1549-57.
12. Sato T, Saito H, Seto K, Takatsuji H. Sleep apneas and cardiac-arrhythmias in freely moving rats. Am J Physiol 1990;259: R282-7.
13. Mendelson WB, Martin JA, Perlis M, Giesen H, Wagner R, Rapoport SI. Periodic cessation of respiratory effort during sleep in adult rats. Physiol Behav 1988;43:229-34.
14. Monti D, Carley DW, Radulovacki M. Adenosine analogs modulate the incidence of sleep apneas in rats. Pharmacol Biochem Behav 1995;51:125-31.
15. Monti D, Carley DW, Radulovacki M. p-SPA, a peripheral adenosine A1 analog reduces sleep apneas in rats. Pharmacol Biochem Behav 1996;53:341-5.
16. Carley DW, Trbovic S, Radulovacki M. Effect of REM sleep deprivation on sleep apneas in rats. Exp Neural 1996;137:291-3.
17. Thomas AJ, Austin W, Friedman L, Strohl KP. A model of ventilatory instability induced in the unrestrained rat. J Appl Physiol 1992;73:1530-6.
18. Thomas AJ, Friedman L, MacKenzie CN, Strohl KP. Modification of conditioned apneas in rats: evidence for cortical involvement. J Appl Physiol 1995;78:1215-8.
19. Carley DW, Trbovic S, Radulovacki M. Sleep apnea in normal and REM sleep deprived normotensive Wistar-Kyoto and spontaneously hypertensive (SHR) rats. Physiol Behav 1996;59:827-31.
20. Barringer DL, Bunag RD. Uneven blunting of chronotropic baroreflexes in obese Zucker rats. Am J Physiol 1989;256:H417-21.
21. Bunag RD, Barringer DL. Obese Zucker rats, though still normotensive, already have impaired chronotropic baroreflexes. Clin Exper Theory Prac 1988;A10Suppl 1:257-62.
22. Chiueh CC, Kopin IJ. Hyperresponsivity of spontaneously hypertensive rats to indirect measurement of blood pressure. Am J Physiol 1978;234:H690-5.
23. Bunag RD. Measurement of blood pressure in rats. In: De Jong W, ed. Handbook of hypertension, vol. 4. Experimental and genetic models of hypertension. Amsterdam: Elsevier Science Publishers, 1984:1-12.
24. Van den Buse M. Circadian rhythms of blood pressure, heart rate, and locomotor activity in spontaneously hypertensive rats as measured with radio-telemetry. Physiol Behav 1994;55:783-7.
25. Epstein RA. Practical implementation of the barometric method for measurement of tidal volume. J Appl Physiol 1980;49:1107-15.
26. Benington JH, Kodali SK, Heller CH. Scoring transitions to REM sleep in rats based on the EEG phenomena of pre-REM sleep: an improved analysis of sleep structure. Sleep 1994;17:28-36.
27. Gatti PJ, Norman WP, Da Silva AMT, Gillis RA. Cardio-respiratory effects produced by microinjecting L-glutamic acid into medullary nuclei associated with the ventral surface of the medulla. Brain Res 1986;381:281-8.
28. Gozal D, Dong X-W, Rector DM, Harper RM. Optical imaging of the ventral medullary surface of the cat: hypoxia-induced differences in neural activation. J Appl Physiol 1993;74:1658-65.
29. Rector DM, Gozal D, Forster HV, et al. Ventral medullary surface activity during sleep, waking, and anesthetic states in the goat. Am J Physiol 1994;267:R1154-60.
30. Harper RM, Gozal D, Aljadeh G, Carroll JL, Dong X-W, Rector DM. Pressor-induced responses of the cat ventral medullary surface. Am J Physiol 1955;2268:R324-33.
31. Maxwell DL, Fuller RW, Nolop KB, Dixon CMS, Hughes JMB. Effects of adenosine on ventilatory responses to hypoxia and hypercapnia in humans. J Appl Physiol 1986;61:1762-6.
32. Watt AH, Routledge PA. Adenosine stimulates respiration in man. Br J Clin Pharmacol 1985;20:503-6.
33. 2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther 1989;251:47-55.
34. Christon J, Carley DW, Monti D, Radulovacki M. Effects of inspired gas on sleep-related apnea in the rat. J Appl Physiol 1996;80:2102-7.