Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease

Neurobiology of Disease

Volumn 66, Issue , 2014, Pages 92-103

  Teixeira, Carla Andreia ^a   Miranda, Catarina Oliveira ^a,b   Sousa, Vera Filipe ^a,b   Santos, Telma Emanuela ^a   Malheiro, Ana Rita ^a   Solomon, Melani ^c   Maegawa, Gustavo H ^c   Brites, Pedro ^a   Sousa, Mónica Mendes ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axonal transport; Endocytosis; Krabbe's disease; Leukodystrophy; Myelin; Twitcher

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PSYCHOSINE; TUBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; FEMALE; GLOBOID CELL LEUKODYSTROPHY; IN VITRO STUDY; LIPID RAFT; MALE; MICROTUBULE; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE FIBER TRANSPORT; NEUROPATHOLOGY; NEUROPATHY; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN MODIFICATION; SCIATIC NERVE INJURY; SIGNAL TRANSDUCTION; SPINAL GANGLION; SYNAPSE VESICLE;

AXONAL TRANSPORT; ENDOCYTOSIS; KRABBE'S DISEASE; LEUKODYSTROPHY; MYELIN; TWITCHER;

ANIMALS; AXONAL TRANSPORT; AXONS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DYNEINS; ENDOCYTOSIS; FEMALE; GANGLIA, SPINAL; LEUKODYSTROPHY, GLOBOID CELL; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, NEUROLOGIC MUTANTS; MICROTUBULES; MOTOR NEURONS; NEURITES; NEURONS; SCIATIC NERVE; SYNAPTIC VESICLES; TRANSPORT VESICLES; TUBULIN;

EID: 84896968554     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.02.012     Document Type: Article

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