The sphingolipid psychosine inhibits fast axonal transport in krabbe disease by activation of GSK3β and deregulation of molecular motors

Journal of Neuroscience

Volumn 33, Issue 24, 2013, Pages 10048-10056

  Cantuti Castelvetri, Ludovico ^a   Givogri, Maria I ^a   Hebert, Amy ^a   Smith, Benjamin ^a   Song, Yuyu ^a   Kaminska, Agnieszka ^a   Lopez Rosas, Aurora ^a   Morfini, Gerardo ^a   Pigino, Gustavo ^a   Sands, Mark ^b   Brady, Scott T ^a   Bongarzone, Ernesto R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LYSOSOME ENZYME; PHOSPHOTRANSFERASE; PSYCHOSINE; SPHINGOLIPID; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MOTILITY; CONTROLLED STUDY; EMBRYO; FEMALE; GENOTYPE; GLOBOID CELL LEUKODYSTROPHY; IMMUNOBLOTTING; LIPID RAFT; MALE; MOUSE; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCIATIC NERVE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; AXONAL TRANSPORT; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOGEN SYNTHASE KINASE 3; LEUKODYSTROPHY, GLOBOID CELL; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MOLECULAR MOTOR PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PSYCHOSINE; SCIATIC NERVE; TIME FACTORS;

EID: 84878890357     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0217-13.2013     Document Type: Article

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