메뉴 건너뛰기




Volumn 19, Issue 3, 2014, Pages 3508-3522

Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and hsp90 client protein degradation

Author keywords

Apoptosis; Celastrol; EGFR; Gefitinib resistance; Hsp90; NSCLC

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; GEFITINIB; HEAT SHOCK PROTEIN 90; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TRIPTERINE; TRITERPENE;

EID: 84896914147     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19033508     Document Type: Article
Times cited : (42)

References (46)
  • 1
    • 77951215549 scopus 로고    scopus 로고
    • Celastrol a triterpene, enhances trail-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
    • Sung, B.; Park, B.; Yadav, V.R.; Aggarwal, B.B. Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. J. Biol. Chem. 2010, 285, 11498-11507.
    • (2010) J. Biol. Chem. , vol.285 , pp. 11498-11507
    • Sung, B.1    Park, B.2    Yadav, V.R.3    Aggarwal, B.B.4
  • 2
    • 0034785173 scopus 로고    scopus 로고
    • A phase i study of ethyl acetate extract of the chinese antirheumatic herb tripterygium wilfordii hook f in rheumatoid arthritis
    • Tao, X.; Cush, J.J.; Garret, M.; Lipsky, P.E. A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis. J. Rheumatol. 2001, 28, 2160-2167.
    • (2001) J. Rheumatol. , vol.28 , pp. 2160-2167
    • Tao, X.1    Cush, J.J.2    Garret, M.3    Lipsky, P.E.4
  • 3
    • 17444428634 scopus 로고    scopus 로고
    • Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in balb/c mice
    • Li, H.; Zhang, Y.Y.; Huang, X.Y.; Sun, Y.N.; Jia, Y.F.; Li, D. Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice. Eur. J. Pharmacol. 2005, 512, 231-237.
    • (2005) Eur. J. Pharmacol. , vol.512 , pp. 231-237
    • Li, H.1    Zhang, Y.Y.2    Huang, X.Y.3    Sun, Y.N.4    Jia, Y.F.5    Li, D.6
  • 4
    • 33744486642 scopus 로고    scopus 로고
    • Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
    • Kiaei, M.; Kipiani, K.; Petri, S.; Chen, J.; Calingasan, N.Y.; Beal, M.F. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener Dis. 2005, 2, 246-254.
    • (2005) Neurodegener Dis. , vol.2 , pp. 246-254
    • Kiaei, M.1    Kipiani, K.2    Petri, S.3    Chen, J.4    Calingasan, N.Y.5    Beal, M.F.6
  • 6
    • 65549142792 scopus 로고    scopus 로고
    • Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model
    • Kim, D.Y.; Park, J.W.; Jeoung, D.; Ro, J.Y. Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur. J. Pharmacol. 2009, 612, 98-105.
    • (2009) Eur. J. Pharmacol. , vol.612 , pp. 98-105
    • Kim, D.Y.1    Park, J.W.2    Jeoung, D.3    Ro, J.Y.4
  • 7
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of akt/mammalian target of rapamycin pathway
    • Pang, X.; Yi, Z.; Zhang, J.; Lu, B.; Sung, B.; Qu, W.; Aggarwal, B.B.; Liu, M. Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res. 2010, 70, 1951-1959.
    • (2010) Cancer Res. , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6    Aggarwal, B.B.7    Liu, M.8
  • 8
    • 33947598693 scopus 로고    scopus 로고
    • Celastrol a novel triterpene, potentiates tnf-induced apoptosis and suppresses invasion of tumor cells by inhibiting nf-kappab-regulated gene products and tak1-mediated nf-kappab activation
    • Sethi, G.; Ahn, K.S.; Pandey, M.K.; Aggarwal, B.B. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood 2007, 109, 2727-2735.
    • (2007) Blood , vol.109 , pp. 2727-2735
    • Sethi, G.1    Ahn, K.S.2    Pandey, M.K.3    Aggarwal, B.B.4
  • 9
    • 33646406554 scopus 로고    scopus 로고
    • Celastrol a triterpene extracted from the chinese "thunder of god vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    • Yang, H.; Chen, D.; Cui, Q.C.; Yuan, X.; Dou, Q.P. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006, 66, 4758-4765.
    • (2006) Cancer Res. , vol.66 , pp. 4758-4765
    • Yang, H.1    Chen, D.2    Cui, Q.C.3    Yuan, X.4    Dou, Q.P.5
  • 10
    • 42649088411 scopus 로고    scopus 로고
    • Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing vegfr expression
    • Huang, Y.; Zhou, Y.; Fan, Y.; Zhou, D. Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett. 2008, 264, 101-106.
    • (2008) Cancer Lett. , vol.264 , pp. 101-106
    • Huang, Y.1    Zhou, Y.2    Fan, Y.3    Zhou, D.4
  • 12
    • 78650236850 scopus 로고    scopus 로고
    • Chemotherapy chemoresistance and the changing treatment landscape for nsclc
    • Chang, A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 2011, 71, 3-10.
    • (2011) Lung Cancer , vol.71 , pp. 3-10
    • Chang, A.1
  • 13
    • 68849105058 scopus 로고    scopus 로고
    • Double egfr mutants containing rare egfr mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations
    • Tam, I.Y.; Leung, E.L.; Tin, V.P.; Chua, D.T.; Sihoe, A.D.; Cheng, L.C.; Chung, L.P.; Wong, M.P. Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations. Mol. Cancer Ther. 2009, 8, 2142-2151.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2142-2151
    • Tam, I.Y.1    Leung, E.L.2    Tin, V.P.3    Chua, D.T.4    Sihoe, A.D.5    Cheng, L.C.6    Chung, L.P.7    Wong, M.P.8
  • 14
    • 67649600824 scopus 로고    scopus 로고
    • Src promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy
    • Leung, E.L.; Tam, I.Y.; Tin, V.P.; Chua, D.T.; Sihoe, A.D.; Cheng, L.C.; Ho, J.C.; Chung, L.P.; Wong, M.P. SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Mol. Cancer Res. 2009, 7, 923-932.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 923-932
    • Leung, E.L.1    Tam, I.Y.2    Tin, V.P.3    Chua, D.T.4    Sihoe, A.D.5    Cheng, L.C.6    Ho, J.C.7    Chung, L.P.8    Wong, M.P.9
  • 15
    • 65249095599 scopus 로고    scopus 로고
    • The eml4-Alk fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type egfr and kras
    • Wong, D.W.; Leung, E.L.; So, K.K.; Tam, I.Y.; Sihoe, A.D.; Cheng, L.C.; Ho, K.K.; Au, J.S.; Chung, L.P.; Pik Wong, M. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 2009, 115, 1723-1733.
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3    Tam, I.Y.4    Sihoe, A.D.5    Cheng, L.C.6    Ho, K.K.7    Au, J.S.8    Chung, L.P.9    Pik Wong, M.10
  • 16
    • 84864835466 scopus 로고    scopus 로고
    • The oncogenic lung cancer fusion kinase cd74-ros activates a novel invasiveness pathway through e-syt1 phosphorylation
    • Jun, H.J.; Johnson, H.; Bronson, R.T.; de Feraudy, S.; White, F.; Charest, A. The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. Cancer Res. 2012, 72, 3764-3774.
    • (2012) Cancer Res. , vol.72 , pp. 3764-3774
    • Jun, H.J.1    Johnson, H.2    Bronson, R.T.3    De Feraudy, S.4    White, F.5    Charest, A.6
  • 17
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch, F.R.; Varella-Garcia, M.; Bunn, P.A., Jr.; di Maria, M.V.; Veve, R.; Bremmes, R.M.; Baron, A.E.; Zeng, C.; Franklin, W.A. Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 2003, 21, 3798-3807.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3    Di Maria, M.V.4    Veve, R.5    Bremmes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 19
    • 33846202907 scopus 로고    scopus 로고
    • Molecular mechanisms of epidermal growth factor receptor (egfr) activation and response to gefitinib and other egfr-targeting drugs
    • Ono, M.; Kuwano, M. Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin. Cancer Res. 2006, 12, 7242-7251.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 7242-7251
    • Ono, M.1    Kuwano, M.2
  • 20
    • 80051746642 scopus 로고    scopus 로고
    • Curcumin induces egfr degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy
    • Lee, J.Y.; Lee, Y.M.; Chang, G.C.; Yu, S.L.; Hsieh, W.Y.; Chen, J.J.; Chen, H.W.; Yang, P.C. Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy. PLoS One 2011, 6, e23756.
    • (2011) PLoS One , vol.6
    • Lee, J.Y.1    Lee, Y.M.2    Chang, G.C.3    Yu, S.L.4    Hsieh, W.Y.5    Chen, J.J.6    Chen, H.W.7    Yang, P.C.8
  • 23
    • 77953078857 scopus 로고    scopus 로고
    • Combined inhibition of igfr enhances the effects of gefitinib in h1650: A lung cancer cell line with egfr mutation and primary resistance to egfr-tk inhibitors
    • Choi, Y.J.; Rho, J.K.; Jeon, B.S.; Choi, S.J.; Park, S.C.; Lee, S.S.; Kim, H.R.; Kim, C.H.; Lee, J.C. Combined inhibition of IGFR enhances the effects of gefitinib in H1650: A lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors. Cancer Chemother. Pharmacol. 2010, 66, 381-388.
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 381-388
    • Choi, Y.J.1    Rho, J.K.2    Jeon, B.S.3    Choi, S.J.4    Park, S.C.5    Lee, S.S.6    Kim, H.R.7    Kim, C.H.8    Lee, J.C.9
  • 25
    • 41649111490 scopus 로고    scopus 로고
    • Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
    • Kim, H.P.; Han, S.W.; Kim, S.H.; Im, S.A.; Oh, D.Y.; Bang, Y.J.; Kim, T.Y. Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells. Mol. Cancer Ther. 2008, 7, 607-615.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 607-615
    • Kim, H.P.1    Han, S.W.2    Kim, S.H.3    Im, S.A.4    Oh, D.Y.5    Bang, Y.J.6    Kim, T.Y.7
  • 27
    • 79957808725 scopus 로고    scopus 로고
    • Olaquindox induces apoptosis through the mitochondrial pathway in hepg2 cells
    • Zou, J.; Chen, Q.; Jin, X.; Tang, S.; Chen, K.; Zhang, T.; Xiao, X. Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells. Toxicology 2011, 285, 104-113.
    • (2011) Toxicology , vol.285 , pp. 104-113
    • Zou, J.1    Chen, Q.2    Jin, X.3    Tang, S.4    Chen, K.5    Zhang, T.6    Xiao, X.7
  • 28
    • 34250760931 scopus 로고    scopus 로고
    • Flex-hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria
    • Liu, T.; Hannafon, B.; Gill, L.; Kelly, W.; Benbrook, D. Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria. Mol. Cancer Ther. 2007, 6, 1814-1822.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1814-1822
    • Liu, T.1    Hannafon, B.2    Gill, L.3    Kelly, W.4    Benbrook, D.5
  • 29
    • 81855218666 scopus 로고    scopus 로고
    • Shikonin a chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
    • Gong, K.; Li, W. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic. Biol. Med. 2011, 51, 2259-2271.
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 2259-2271
    • Gong, K.1    Li, W.2
  • 32
    • 27644584179 scopus 로고    scopus 로고
    • Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a nur77-dependent pathway
    • Maddika, S.; Booy, E.P.; Johar, D.; Gibson, S.B.; Ghavami, S.; Los, M. Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway. J. Cell Sci. 2005, 118, 4485-4493.
    • (2005) J. Cell Sci. , vol.118 , pp. 4485-4493
    • Maddika, S.1    Booy, E.P.2    Johar, D.3    Gibson, S.B.4    Ghavami, S.5    Los, M.6
  • 33
    • 67349200795 scopus 로고    scopus 로고
    • The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in fl cells
    • Eeva, J.; Nuutinen, U.; Ropponen, A.; Matto, M.; Eray, M.; Pellinen, R.; Wahlfors, J.; Pelkonen, J. The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells. Apoptosis 2009, 14, 687-698.
    • (2009) Apoptosis , vol.14 , pp. 687-698
    • Eeva, J.1    Nuutinen, U.2    Ropponen, A.3    Matto, M.4    Eray, M.5    Pellinen, R.6    Wahlfors, J.7    Pelkonen, J.8
  • 34
    • 79955855304 scopus 로고    scopus 로고
    • Celastrol targets mitochondrial respiratory chain complex i to induce reactive oxygen species-dependent cytotoxicity in tumor cells
    • Chen, G.; Zhang, X.; Zhao, M.; Wang, Y.; Cheng, X.; Wang, D.; Xu, Y.; Du, Z.; Yu, X. Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. BMC Cancer 2011, 11, 170.
    • (2011) BMC Cancer , vol.11 , pp. 170
    • Chen, G.1    Zhang, X.2    Zhao, M.3    Wang, Y.4    Cheng, X.5    Wang, D.6    Xu, Y.7    Du, Z.8    Yu, X.9
  • 35
    • 62949238913 scopus 로고    scopus 로고
    • New developments in hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential
    • Li, Y.; Zhang, T.; Schwartz, S.J.; Sun, D. New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential. Drug Resist. Updat. 2009, 12, 17-27.
    • (2009) Drug Resist. Updat. , vol.12 , pp. 17-27
    • Li, Y.1    Zhang, T.2    Schwartz, S.J.3    Sun, D.4
  • 37
    • 70449412700 scopus 로고    scopus 로고
    • The nf-kappa b inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
    • He, D.; Xu, Q.; Yan, M.; Zhang, P.; Zhou, X.; Zhang, Z.; Duan, W.; Zhong, L.; Ye, D.; Chen, W. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC Cancer 2009, 9, 343.
    • (2009) BMC Cancer , vol.9 , pp. 343
    • He, D.1    Xu, Q.2    Yan, M.3    Zhang, P.4    Zhou, X.5    Zhang, Z.6    Duan, W.7    Zhong, L.8    Ye, D.9    Chen, W.10
  • 38
    • 84872841568 scopus 로고    scopus 로고
    • Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the mapk family and the mitochondria dependent pathway
    • Lee, M.S.; Chao, J.; Yen, J.C.; Lin, L.W.; Tsai, F.S.; Hsieh, M.T.; Peng, W.H.; Cheng, H.Y. Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway. Molecules 2012, 18, 354-72.
    • (2012) Molecules , vol.18 , pp. 354-372
    • Lee, M.S.1    Chao, J.2    Yen, J.C.3    Lin, L.W.4    Tsai, F.S.5    Hsieh, M.T.6    Peng, W.H.7    Cheng, H.Y.8
  • 39
    • 49149088537 scopus 로고    scopus 로고
    • Induction of apoptosis by shikonin through a ros/jnkmediated process in bcr/abl-positive chronic myelogenous leukemia (cml) cells
    • Mao, X.; Yu, C.R.; Li, W.H.; Li, W.X. Induction of apoptosis by shikonin through a ROS/JNKmediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell Res. 2008, 18, 879-888.
    • (2008) Cell Res. , vol.18 , pp. 879-888
    • Mao, X.1    Yu, C.R.2    Li, W.H.3    Li, W.X.4
  • 40
    • 67650930911 scopus 로고    scopus 로고
    • Heat-shock protein 90 (hsp90) as a molecular target for therapy of gastrointestinal cancer
    • Moser, C.; Lang, S.A.; Stoeltzing, O. Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer. Anticancer Res. 2009, 29, 2031-2042.
    • (2009) Anticancer Res. , vol.29 , pp. 2031-2042
    • Moser, C.1    Lang, S.A.2    Stoeltzing, O.3
  • 41
    • 0037131187 scopus 로고    scopus 로고
    • Akt forms an intracellular complex with heat shock protein 90 (hsp90) and cdc37 and is destabilized by inhibitors of hsp90 function
    • Basso, A.D.; Solit, D.B.; Chiosis, G.; Giri, B.; Tsichlis, P.; Rosen, N. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J. Biol. Chem. 2002, 277, 39858-39866.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39858-39866
    • Basso, A.D.1    Solit, D.B.2    Chiosis, G.3    Giri, B.4    Tsichlis, P.5    Rosen, N.6
  • 42
    • 0028786332 scopus 로고
    • Disruption of the raf-1-hsp90 molecular complex results in destabilization of raf-1 and loss of raf-1-ras association
    • Schulte, T.W.; Blagosklonny, M.V.; Ingui, C.; Neckers, L. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. J. Biol. Chem. 1995, 270, 24585-24588.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24585-24588
    • Schulte, T.W.1    Blagosklonny, M.V.2    Ingui, C.3    Neckers, L.4
  • 43
    • 39049150922 scopus 로고    scopus 로고
    • Inhibition of hsp90 down-regulates mutant epidermal growth factor receptor (egfr) expression and sensitizes egfr mutant tumors to paclitaxel
    • Sawai, A.; Chandarlapaty, S.; Greulich, H.; Gonen, M.; Ye, Q.; Arteaga, C.L.; Sellers, W.; Rosen, N.; Solit, D.B. Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Res. 2008, 68, 589-596.
    • (2008) Cancer Res. , vol.68 , pp. 589-596
    • Sawai, A.1    Chandarlapaty, S.2    Greulich, H.3    Gonen, M.4    Ye, Q.5    Arteaga, C.L.6    Sellers, W.7    Rosen, N.8    Solit, D.B.9
  • 45
    • 84894042781 scopus 로고    scopus 로고
    • Cancerous inhibitor of pp2a is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
    • doi:10.1093/carcin/bgt395
    • Liu, Z.; Ma, L.; Wen, Z.S.; Hu, Z.; Wu, F.Q.; Li, W.; Liu, J.; Zhou, G.B. Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer. Carcinogenesis 2013, doi:10.1093/carcin/bgt395.
    • Carcinogenesis , vol.2013
    • Liu, Z.1    Ma, L.2    Wen, Z.S.3    Hu, Z.4    Wu, F.Q.5    Li, W.6    Liu, J.7    Zhou, G.B.8
  • 46
    • 79957961355 scopus 로고    scopus 로고
    • Celastrol induces apoptosis in non-small-cell lung cancer a549 cells through activation of mitochondria- and fas/fasl-mediated pathways
    • Mou, H.; Zheng, Y.; Zhao, P.; Bao, H.; Fang, W.; Xu, N. Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. Toxicol. In Vitro 2011, 25, 1027-1032.
    • (2011) Toxicol. In Vitro , vol.25 , pp. 1027-1032
    • Mou, H.1    Zheng, Y.2    Zhao, P.3    Bao, H.4    Fang, W.5    Xu, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.