Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

European Journal of Pharmacology

Volumn 612, Issue 1-3, 2009, Pages 98-105

  Kim, Dae Yong ^a   Park, Jung Won ^b   Jeoung, Dooil ^c   Ro, Jai Youl ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

Inflammatory cytokine; MAP kinase; MMPs; NF B; TIMPs

Indexed keywords

ALLERGEN; CELASTROL; DRUG VEHICLE; GAMMA INTERFERON; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OVALBUMIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY CONSTRICTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GOBLET CELL; HISTOPATHOLOGY; IMMUNOMODULATION; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; WESTERN BLOTTING;

ALLERGENS; ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LUNG; MATRIX METALLOPROTEINASES; MICE; OVALBUMIN; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; TRITERPENES;

EID: 65549142792     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.03.078     Document Type: Article

References (41)

1. Abel M., and Vliagoflis H. Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: role for IgE-mediated mast cell activation. J. Immunol. 180 (2008) 3543-3550
2. Blease K. Targeting kinases in asthma. Expert Opin. Investig. Drugs 14 (2005) 1212-1220
3. Bond M., Fabunmi R.P., Baker A.H., and Newby A.C. Synergistic up-regulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB. FEBS Lett. 435 (1998) 29-34
4. Calixto J.B., Campos M.M., Otuki M.F., and Santos A.R. Anti-inflammatory compounds of plant origin. Part II: modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med. 70 (2004) 93-103
5. Cho S.H., Stanciu L.A., Holgate S.A., and Johnsyon S.L. Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma. Am. J. Respir. Crit. Care Med. 171 (2005) 224-230
6. Choi J.M., Ahn M.H., Chae W.J., Jung Y.G., Park J.C., Song H.M., Kim Y.E., Shin J.A., Park C.S., Park J.W., Park T.K., Lee J.H., Seo B.F., Kim K.D., Kim E.S., Lee D.H., Lee S.K., and Lee S.K. Intranasal delivery of cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat. Med. 12 (2006) 574-579
7. Dedeoglu F., Horwitz B., Chaudhuri J., Alt F.W., and Geha R.S. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFκB. Int. Immunol. 16 (2004) 395-404
8. Girolamo N.D., Indoh I., Jackson N., Wakefield D., McNeil H.P., Yan W., Geezy C., Arm J.P., and Tedla N. Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration. J. Immunol. 177 (2006) 2638-2650
9. Gueders M.M., Bertholet P., Perin F., Rocks N., Maree R., Botta V., Louis R., Foidart J.-M., Noel A., Evrard B., and Cataldo D.D. A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyper-responsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma. Biochem. Pharmacol. 75 (2008) 514-526
10. Henry M.T., McMahon K., Mackarel A.J., Prikk K., Sorsa T., Maisi P., Sepper R., FitzGerald M.X., and O'Connor C.M. Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarciodosis and IPF. Eur. Respir. J. 20 (2002) 1220-1227
11. Hur G.Y., Shen S.S., Kang Y.M., Koh D.H., Park H.J., Ye Y.M., Yim H.E., Kim K.S., and Park H.S. Histamine release and inflammatory cell infiltration in airway mucosa in methylene diphenyl diisocyanate (MDI)-induced occupational asthma. J. Clin. Immunol. (2008) 10.1007/s10875-008-9199-y
12. Jin H.Z., Hwang B.Y., Kim H.S., Lee J.H., Kim Y.H., and Lee J.J. Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production. J. Nat. Prod. 65 (2002) 89-91
13. Kim D.Y., Ryu S.Y., Lim J.E., Lee Y.S., and Ro J.Y. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur. J. Pharmacol. 557 (2007) 76-86
14. Kim Y.K., Oh S.Y., Jeon S.G., Park H.W., Lee S.Y., Chun E.Y., Bang B., Lee H.S., Oh M.H., Kim Y.S., Kim J.H., Gho Y.S., Cho S.H., Min K.U., Kim Y.Y., and Zhu Z. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J. Immunol. 178 (2007) 5375-5382
15. Kimata M., Ishizaki M., Tanaka H., Nagai H., and Inagaki N. Production of matrix metalloproteinase in human cultured mast cells: involvement of protein kinase C-mitogen activated protein kinase kinase-extracellular signal-regulated kinase pathway. Allergol. Intern. 55 (2006) 67-76
16. Ko F.W., Diba C., Roth M., McKay K., Johnson P.R., Salome C., and King G.G. A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion. Chest 127 (2005) 1919-1927
17. Kumagai K., Ohno I., Okada S., Ohkawara Y., Suzuki K., Shinya T., Nagase H., Iwata K., and Shirato K. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J. Immunol. 162 (1999) 4212-4219
18. Lanone S., Zheng T., Zhu Z., Liu W., Lee C.G., Ma B., Chen Q., Homer R.J., Wang J., Rabach L.A., Robach M.E., Shipley J.M., Shapiro S.D., Senior R.M., and Elias J.A. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J. Clin. Invest. 110 (2002) 463-474
19. Lee Y.N., Tuckerman J., Nechshtan H., Schutz G., Razin E., and Angel P. c-Fos as a regulator of degranulation and cytokine production in Fcepsilon RI-activated mast cells. J. Immunol. 173 (2004) 2571-2577
20. Lee J.H., Koo T.H., Yoon H., Jung H.S., Jin H.Z., Lee K., Hong Y.S., and Lee J.J. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem. Pharmacol. 72 (2006) 1311-1321
21. Liang K.C., Lee C.W., Lin W.N., Lin C.C., Wu C.B., Luo S.F., and Yang C.M. Interleukin-1 beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells. J. Cell. Physiol. 211 (2007) 759-770
22. Liu R.L., Liu Z.L., Li Q., Qiu Z.M., Lü H.J., Yang Z.M., and Hong G.C. The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice. Zhonghua Jie He He Hu Xi Za Zhi 27 (2004) 165-168
23. Locke N.R., Royce S.G., Wainewright J.S., Samuel C.S., and Tang M.L. Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. Am. J. Respir. Cell Mol. Biol. 36 (2007) 625-632
24. McMillan S.J., Kearley J., Campbell J.D., Zhu X.-W., Narbi K.Y., Shipley J.M., Senior R.M., Nourshargh S., and Lloyd C.M. Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J. Immunol. 172 (2004) 2586-2594
25. Nakae S., Lunderius C., Ho L.H., Schafer B., Tsai M., and Galli S.J. TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice. J. Allergy Clin. Immunol. 119 (2007) 680-686
26. Opdenakker G., Van den Steen P.E., and Van Damme J. Gelatinase B: a turn and amplifier of immune functions. Trends Immunol. 22 (2001) 571-579
27. Penido C., Costa K.A., Costa M.F., Pereira J.F., Siani A.C., and Henriques M.G. Inhibition of allergen-induced eosinophil recruitment by natural tetranortriterpenoids is mediated by the suppression of IL-5, CCL11/eotaxin and NF-kappaB activation. Int. Immunopharmacol. 6 (2006) 109-121
28. Picado C., Bioque G., Roca-Ferrer J., Pujols L., Mullol J., Benitez P., and Bulbena O. Nuclear factor-κB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy 58 (2003) 122-126
29. Ray R.M., Vaidya R.J., and Johnson L.R. MEK/ERK regulates adherens junctions and migration through Rac1. Cell Motil. Cytoskelet. 643 (2007) 143-156
30. Renauld J.-C. New insight into the role of cytokines in asthma. J. Clin. Pathol. 54 (2001) 577-589
31. Secor Jr. E.R., Carson IV W.F., Singh A., Pensa M., Guernsey L.A., Schramm C.M., and Thrall R.S. Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma. Evid.-Based Compl. Alt. Med. 5 (2008) 61-69
32. Sergejeva S., Ivanov S., Lotvall J., and Linden A. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am. J. Respir. Cell mol. Biol. 33 (2005) 248-253
33. Sethi G., Ahn K.S., Pandey M.K., and Aggarwal B.B. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappa B-regulated gene products and TAK1-mediated NF-kappa B activation. Blood 109 (2007) 2727-2735
34. Tao X., Younger J., Fan F.Z., Wang B., and Lipsky P.E. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum. 46 (2002) 1735-1743
35. Venuprasad K., Elly C., Gao M., Salek-Ardakani S., Harasa Y., Luo J.-L., Yang C., Croft M., Inoue K., and Liu Y.C. Convergence of itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J. Clin. Invest. 116 (2006) 1117-1126
36. Vignola A.M., Riccobono L., Mirabella A., Profilta M., Chanez P., Bellia V., Mautino G., D'accardi P., Bousquet J., and Bonsignore G. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 158 (1998) 1945-1950
37. Wills-Karp M., and Karp C.L. Eosinophils in asthma: remodeling a tangled tale. Science 305 (2004) 1726-1729
38. Zheng T., Zhu Z., Wang Z., Homer R.J., Ma B., Riese R.J., Chapman H.A., Shapiro S.D., and Elias J.A. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema. J. Clin. Invest. 106 (2000) 1081-1093
39. Zhou B.N. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem. Inst. Oswaldo Cruz 2 (1991) 219-226
40. Zimmermann N., Hershey G.K., Foster P.S., and Rothenberg M.E. Chemokines in asthma: Cooperative interaction between chemokines and IL-13. J. Allergy Clin. Immunol. 111 (2003) 227-242
41. Zosky G.R., Larcombe A.N., White O.J., Burchell J.T., Janosi T.Z., Hantos Z., Holt P.G., Sly P.D., and Turner D.J. Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation. Clin. Exp. Allergy 38 (2008) 829-838