Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3014-3019

  Valastyan, Julie S ^a,b   Termine, Daniel J ^a   Lindquist, Susan ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BINDING PROTEIN; FLUCONAZOLE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPROTEIN; LIPID; PROTEIN VARIANT; SIMVASTATIN; STEROL;

ARTICLE; CELL MEMBRANE; CELL VACUOLE; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DEGENERATIVE DISEASE; EXON; GENETIC ANALYSIS; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STEROL SYNTHESIS;

ALPHA-SYNUCLEIN; BLOTTING, WESTERN; CELL MEMBRANE; DNA PRIMERS; ENDOPLASMIC RETICULUM; FLUCONAZOLE; LINEAR MODELS; MICROSCOPY, FLUORESCENCE; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE DELETION; STEROLS; YEASTS;

EID: 84896865726     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324209111     Document Type: Article

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