Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae

Fungal Genetics and Biology

Volumn 45, Issue 10, 2008, Pages 1430-1438

  Marie, Chelsea ^a,b   Leyde, Sarah ^a,b   White, Theodore C ^a,b  

^a School of Public Health and Community Medicine   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Azole resistance; ECM22; Ergosterol; FACS; GFP; Post translational regulation; SREBP; UPC2

Indexed keywords

ERGOSTEROL; HYBRID PROTEIN; PYRROLE DERIVATIVE; TRANSCRIPTION FACTOR;

ARTICLE; CYTOPLASM; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; INTRACELLULAR MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; STEROL ANALYSIS; STEROL METABOLISM; STEROL SYNTHESIS; YEAST CELL;

AZOLES; CYTOPLASM; ERGOSTEROL; GREEN FLUORESCENT PROTEINS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 53049094207     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2008.07.004     Document Type: Article

References (32)

1. Abramova N.E., et al. Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae. Genetics 157 3 (2001) 1169-1177
2. Adams A.K.C., and Gottschling D. Methods in Yeast Genetics (1995), Cold Springs Harbor Laboratory Press, Cold Springs Harbor, NY
3. Arthington-Skaggs B.A., et al. Quantitation of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans. J. Clin. Microbiol. 37 10 (1999) 3332-3337
4. Beals C.R., et al. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11 7 (1997) 824-834
5. Bolte S., and Cordelieres F.P. A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 224 Pt. 3 (2006) 213-232
6. Chang Y.C., et al. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol. Microbiol. 64 3 (2007) 614-629
7. Chun C.D., Liu O.W., and Madhani H.D. A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. PLoS Pathog. 3 2 (2007) e22
8. Crowley J.H., et al. A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae. J. Bacteriol. 180 16 (1998) 4177-4183
9. Davies B.S., and Rine J. A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. Genetics 174 1 (2006) 191-201
10. Davies B.S., Wang H.S., and Rine J. Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Mol. Cell. Biol. 25 16 (2005) 7375-7385
11. Espenshade P.J., and Hughes A.L. Regulation of sterol synthesis in eukaryotes. Annu. Rev. Genet. 41 (2007) 401-427
12. Fluckiger U., et al. Treatment options of invasive fungal infections in adults. Swiss Med. Wkly. 136 29-30 (2006) 447-463
13. Germann M., et al. Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. J. Biol. Chem. 280 43 (2005) 35904-35913
14. Guthrie, C., Fink, G. (Eds.), 1991. Guide to Yeast Genetics and Molecular Biology. Academic Press, Inc., San Diego, p. 933.
15. Habeler G., et al. YPL.db: the yeast protein localization database. Nucleic Acids Res. 30 1 (2002) 80-83
16. Henneberry A.L., and Sturley S.L. Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae. Semin. Cell Dev. Biol. 16 2 (2005) 155-161
17. Hughes A.L., Todd B.L., and Espenshade P.J. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120 6 (2005) 831-842
18. Huh W.K., et al. Global analysis of protein localization in budding yeast. Nature 425 6959 (2003) 686-691
19. Kwast K.E., Burke P.V., and Poyton R.O. Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J. Exp. Biol. 201 Pt. 8 (1998) 1177-1195
20. Lee H., et al. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol. Microbiol. 65 4 (2007) 1018-1033
21. MacPherson S., Larochelle M., and Turcotte B. A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol. Mol. Biol. Rev. 70 3 (2006) 583-604
22. Maniatis T., Fritsch E.F., and Sambrook J. Molecular Cloning: A Laboratory Manual (1982), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
23. Parks L.W., and Casey W.M. Physiological implications of sterol biosynthesis in yeast. Annu. Rev. Microbiol. 49 (1995) 95-116
24. Shianna K.V., et al. Identification of a UPC2 homolog in Saccharomyces cerevisiae and its involvement in aerobic sterol uptake. J. Bacteriol. 183 3 (2001) 830-834
25. Smith S.J., Crowley J.H., and Parks L.W. Transcriptional regulation by ergosterol in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 16 10 (1996) 5427-5432
26. Song J.L., et al. The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs. Antimicrob. Agents Chemother. 48 4 (2004) 1136-1144
27. Standards N.C.C.L.S. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard M27-A2. second ed. (2002), Clinical Laboratory Standards Institute, Wayne, PA
28. Stathopoulos-Gerontides A., Guo J.J., and Cyert M.S. Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes Dev. 13 7 (1999) 798-803
29. Todd R.B., and Andrianopoulos A. Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet. Biol. 21 3 (1997) 388-405
30. Valachovic M., et al. Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Genetics 173 4 (2006) 1893-1908
31. Vik A., and Rine J. Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 21 19 (2001) 6395-6405
32. White T.C., and Silver P.M. Regulation of sterol metabolism in Candida albicans by the UPC2 gene. Biochem. Soc. Trans. 33 Pt. 5 (2005) 1215-1218