Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation

International Immunopharmacology

Volumn 19, Issue 2, 2014, Pages 233-244

  Yu, Hao ^a   Zheng, Lingli ^a   Yin, Lianhong ^a   Xu, Lina ^a   Qi, Yan ^a   Han, Xu ^a   Xu, Youwei ^a   Liu, Kexin ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

CCl4 induced hepatotoxicity; D. nipponica Makino; Liver injury; Natural product; Total saponins

Indexed keywords

CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; CYTOCHROME P450 2E1; DIOSCOREA NIPPONICA EXTRACT; FAS ANTIGEN; FAS LIGAND; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PLANT EXTRACT; PROTECTIVE AGENT; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS; CONTROLLED STUDY; DIOSCOREA NIPPONICA; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INFLAMMATION; LIVER PROTECTION; LIVER WEIGHT; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; YAM;

CCL(4)-INDUCED HEPATOTOXICITY; D. NIPPONICA MAKINO; LIVER INJURY; NATURAL PRODUCT; TOTAL SAPONINS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; DIOSCOREA; DRUG-INDUCED LIVER INJURY; MALE; MICE; PLANT EXTRACTS; SAPONINS;

EID: 84896850686     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.01.019     Document Type: Article

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