Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria

Cancer Letters

Volumn 224, Issue 2, 2005, Pages 229-241

  Liu, Ming Jie ^a   Yue, Patrick Ying Kit ^b   Wang, Zhao ^a   Wong, Ricky Ngok Shun ^b  

^a TSINGHUA UNIVERSITY   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Apoptosis; Ca2+ homeostasis; G2 M arrest; Methyl protodioscin; Mitochondrial hyperpolarization

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DNA FRAGMENT; GLYCOSIDE; LIPOCORTIN 5; METHYL PROTODIOSCIN; PROTEIN BAX; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE G2 PHASE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL POPULATION; CELL PROTECTION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOSIS INHIBITION; POLYPLOIDY; PRIORITY JOURNAL; UPREGULATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CELL CYCLE; CELL PROLIFERATION; DIOSGENIN; DNA DAMAGE; HOMEOSTASIS; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SAPONINS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 19444376774     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.11.051     Document Type: Article

References (28)

1. R.W. Johnstone, A.A. Ruefli, and S.W. Lowe Apoptosis: a link between cancer genetics and chemotherapy Cell 108 2002 153 164
2. E.A. Sausville, Y. Elsayed, M. Monga, and G. Kim Signal transduction-directed cancer treatments Annu. Rev. Pharmacol. Toxicol. 43 2003 199 231
3. S.J. Elledge Cell cycle checkpoints: preventing an identity crisis Science 274 1996 1664 1672
4. D. Arion, L. Meijer, L. Brizuela, and D. Beach Cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF Cell 55 1988 371 378
5. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312
6. S. Desagher, and J.C. Martinou Mitochondria as the central control point of apoptosis Trends Cell. Biol. 10 2000 369 377
7. X. Jiang, and X. Wang Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 J. Biol. Chem. 275 2000 31199 31203
8. S. Cory, and J.M. Adams The Bcl-2 family: regulators of the cellular life-or-death switch Nat. Rev. Cancer 2 2002 647 656
9. M. Crompton The mitochondrial permeability transition pore and its role in cell death Biochem. J. 341 1999 233 249
10. M.R. Duchen Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signaling and cell death J. Physiol. 516 1999 1 17
11. S. Orrenius, B. Zhivotovsky, and P. Nicotera Regulation of cell death: the calcium-apoptosis link Nat. Rev. Mol. Cell Biol. 4 2003 552 565
12. K. Hu, A. Dong, X. Yao, H. Kobayashi, and S. Iwasaki Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca Planta Med. 62 1996 573 575
13. K. Hu, and X.S. Yao Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel Planta Med. 68 2002 297 301
14. J. Yin, Y. Tezuka, K. Kouda, Q.L. Tran, T. Miyahara, Y.J. Chen, and S. Kadota In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin Planta Med. 70 2004 220 226
15. M.S. Cheng, Q.L. Wang, Q. Tian, H.Y. Song, Y.X. Liu, and Q. Li Total synthesis of methyl protodioscin: a potent agent with antitumor activity J. Org. Chem. 68 2003 3658 3662
16. Z. Wang, J. Zhou, Y. Ju, H. Zhang, M. Liu, and X. Li Effects of two saponins extracted from the Polygonatum zanlanscianse on the human leukemia (HL-60) cells Biol. Pharm. Bull. 24 2001 159 162
17. M. Lubbert, C.W. Miller, L. Crawford, and H.P. Koeffler p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression J. Exp. Med. 167 1988 873 886
18. M.A. Jordan, K. Wendell, S. Gardiner, W.B. Derry, H. Copp, and L. Wilson Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death Cancer Res. 56 1996 816 825
19. 2 checkpoint through cyclin B1 Proc. Natl Acad. Sci. USA 96 1999 2147 2152
20. P.F. Li, R. Dietz, and R. von Harsdorf p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c independent apoptosis blocked by bcl-2 Eur. Mol. Biol. Organ. J. 18 1999 6027 6036
21. L prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange Mol. Cell 3 1999 159 167
22. J.C. Reed, J.M. Jurgensmeier, and S. Matsuyama Bcl-2 family proteins and mitochondria Biochim. Biophys. Acta - Bioenergetics 1366 1998 127 137
23. S. Matsuyama, J. Lopis, Q.L. Deveraux, R.Y. Tsien, and J.C. Reed Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis Nat. Cell Biol. 2 2000 318 325
24. K.B. Wallace, J.T. Eells, V.M.C. Madeira, G. Cortopassi, and D.P. Jones Mitochondria-mediated cell injury Fundam. Appl. Toxicol. 38 1997 23 37
25. A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev. 13 1999 1899 1911
26. A.J. Minn, L.H. Boise, and C.B. Thompson Expression of bcl-x(L) and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage Genes Dev. 10 1996 2621 2631
27. 2+ homeostasis by Bcl-2 J. Biol. Chem. 274 1999 33267 33273
28. G. Kroemer, B. Dallaporta, and M. Resche-Rigon The mitochondrial death/life regulation of apoptosis and necrosis Annu. Rev. Physiol. 60 1998 619 642