Tetraploidization increases sensitivity to Aurora B kinase inhibition

Cell Cycle

Volumn 11, Issue 13, 2012, Pages 2567-2577

  Marxer, Miriam ^a   Foucar, Charles E ^a   Man, Wing Yu ^a   Chen, Yu ^a   Ma, Hoi Tang ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Aurora kinases; Cancer; Cell cycle; Mitosis; Tetraploidy

Indexed keywords

ALISERTIB; AURORA B KINASE; DIHYDROCYTOCHALASIN B; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHROMOSOME DUPLICATION; CONTROLLED STUDY; CYTOKINESIS; DIPLOIDY; ENZYME INHIBITION; FIBROBLAST; LETHALITY; LIVER CELL CARCINOMA; MAMMAL CELL; MOUSE; NONHUMAN; PLOIDY; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; TETRAPLOIDY; YEAST;

MAMMALIA;

EID: 84863787422     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.20947     Document Type: Article

References (31)

1. Scarbrough PR, Hersh J, Kukolich MK, Carroll AJ, Finley SC, Hochberger R, et al. Tetraploidy: a report of three live-born infants. Am J Med Genet 1984; 19:29-37; PMID:6496571; http://dx.doi.org/10.1002/ajmg.1320190106.
2. Conlon I, Raff M. Size control in animal development. Cell 1999; 96:235-44; PMID:9988218; http://dx.doi. org/10.1016/S0092-8674(00)80563-2.
3. Poon RYC. Polyploidization and cancer. New York: Springer 2010.
4. Ohno S. Evolution by gene duplication. New York: Springer-Verlag 1970.
5. Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194:23-8; PMID:959840; http://dx.doi.org/10.1126/science.959840.
6. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 2007; 17:157-62; PMID:17324569; http://dx.doi. org/10.1016/j.gde.2007.02.011.
7. Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 2004; 5:45-54; PMID:14708009; http://dx.doi.org/10.1038/nrm1276.
8. 2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus. Cancer Res 2003; 63:4211-7; PMID:12874028.
9. 2/tetraploid) populations and progression to aneuploidy in Barrett's esophagus. Proc Natl Acad Sci USA 1996; 93:7081-4; PMID:8692948; http://dx.doi. org/10.1073/pnas.93.14.7081.
10. Olaharski AJ, Sotelo R, Solorza-Luna G, Gonsebatt ME, Guzman P, Mohar A, et al. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 2006; 27:337-43; PMID:16123119; http://dx.doi.org/10.1093/carcin/bgi218.
11. Cowell JK, Wigley CB. Changes in DNA content during in vitro transformation of mouse salivary gland epithelium. J Natl Cancer Inst 1980; 64:1443-9; PMID:6929380.
12. Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 2005; 437:1038-42; PMID:16222248; http://dx.doi.org/10.1038/nature03958.
13. Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 2010; 141:81-93; PMID:20371347; http://dx.doi. org/10.1016/j.cell.2010.01.031.
14. Larizza L, Schirrmacher V. Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants. Cancer Metastasis Rev 1984; 3:193-222; PMID:6388823; http://dx.doi.org/10.1007/BF00048385.
15. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043-7; PMID:16222300; http://dx.doi. org/10.1038/nature04217.
16. Ho CC, Hau PM, Marxer M, Poon RYC. The requirement of p53 for maintaining chromosomal stability during tetraploidization. Oncotarget 2010; 1:583-95; PMID:21317454.
17. Storchová Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, et al. Genome-wide genetic analysis of polyploidy in yeast. Nature 2006; 443:541-7; PMID:17024086; http://dx.doi.org/10.1038/nature05178.
18. Ma HT, Poon RYC. How protein kinases co-ordinate mitosis in animal cells. Biochem J 2011; 435:17-31; PMID:21406064; http://dx.doi.org/10.1042/BJ20100284.
19. Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol 2007; 8:798-812; PMID:17848966; http:// dx.doi.org/10.1038/nrm2257.
20. Kimura M, Matsuda Y, Yoshioka T, Okano Y. Cell cycledependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J Biol Chem 1999; 274:7334-40; PMID:10066797; http://dx.doi.org/10.1074/ jbc.274.11.7334.
21. Dieterich K, Soto Rifo R, Faure AK, Hennebicq S, Ben Amar B, Zahi M, et al. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Nat Genet 2007; 39:661-5; PMID:17435757; http://dx.doi.org/10.1038/ng2027.
22. Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta 2010; 1799:829-39; PMID:20863917.
23. Hau PM, Siu WY, Wong N, Lai PB, Poon RYC. Polyploidization increases the sensitivity to DNAdamaging agents in mammalian cells. FEBS Lett 2006; 580:4727-36; PMID:16887121; http://dx.doi. org/10.1016/j.febslet.2006.07.059.
24. Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2 and Cenp-E to kinetochores. J Cell Biol 2003; 161:267-80; PMID:12719470; http://dx.doi. org/10.1083/jcb.200208091.
25. Sloane DA, Trikic MZ, Chu ML, Lamers MB, Mason CS, Mueller I, et al. Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237. ACS Chem Biol 2010; 5:563-76; PMID:20426425; http:// dx.doi.org/10.1021/cb100053q.
26. Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114:585-98; PMID:13678582; http://dx.doi. org/10.1016/S0092-8674(03)00642-1.
27. Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, et al. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 2004; 279:12997-3003; PMID:14722118; http://dx.doi.org/10.1074/jbc.M311128200.
28. Ma HT, Tsang YH, Marxer M, Poon RYC. Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis. Mol Cell Biol 2009; 29:6500-14; PMID:19822658; http://dx.doi. org/10.1128/MCB.00669-09.
29. Yam CH, Siu WY, Lau A, Poon RYC. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. J Biol Chem 2000; 275:3158-67; PMID:10652300; http://dx.doi. org/10.1074/jbc.275.5.3158.
30. Siu WY, Arooz T, Poon RYC. Differential responses of proliferating versus quiescent cells to adriamycin. Exp Cell Res 1999; 250:131-41; PMID:10388527; http:// dx.doi.org/10.1006/excr.1999.4551.
31. Poon RYC, Toyoshima H, Hunter T. Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell 1995; 6:1197-213; PMID:8534916.