Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interference

Genomics

Volumn 93, Issue 4, 2009, Pages 392-396

  Fortunato, Angelo ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Caenorhabditis elegans; Chromosome III; Efl 1 E2F; Embryonic development; Interference of RNA; Synthetic phenotype

Indexed keywords

SYNTHETIC DNA; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR ELF 1;

ARTICLE; CAENORHABDITIS ELEGANS; CHROMOSOME 3; EMBRYO DEVELOPMENT; GENE INTERACTION; HIGH THROUGHPUT SCREENING; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA INTERFERENCE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; GENES, HELMINTH; RNA INTERFERENCE;

CAENORHABDITIS ELEGANS;

EID: 62149124046     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2008.11.006     Document Type: Article

References (16)

1. Hartwell L.H., Hopfield J.J., Leibler S., and Murray A.W. From molecular to modular cell biology. Nature 402 (1999) C47-C52
2. Piano F., Gunsalus K.C., Hill D.E., and Vidal M. C. elegans network biology: a beginning. WormBook 21 (2006) 1-20
3. Li S., Armstrong C.M., Bertin N., Ge M., Milstein S., Boxem M., Vidalain P.-O., Han J.-D.J., Chesneau A., Hao T., et al. A map of the interactome network of the metazoan C. elegans. Science 303 (2004) 540-543
4. NBrowse. http://www.gnetbrowse.org accessed Dicember 2007
5. Lehner B., Crombie C., Tischler J., Fortunato A., and Fraser A.G. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat. Genet. 38 (2006) 896-903
6. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
7. Nevins J.R. The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10 (2001) 699-703
8. Höglinger G.U., Breunig J.J., Depboylu C., Rouaux C., Michel P.P., Alvarez-Fischer D., Boutillier A.-L., DeGregori J., Oertel W.H., Rakic P., et al. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc. Natl. Acad. Sci. 104 (2007) 3585-3590
9. Timmons L., and Fire A. Specific interference by ingested dsRNA. Nature 395 (1998) 854
10. Fraser A.G., Kamath R.S., Zipperlen P., Martinez-Campos M., Sohrmann M., Ahringer J., et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408 (2000) 325-330
11. Timmons L., Court D.L., and Fire A. Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263 (2001) 103-112
12. Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M., et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421 (2003) 231-237
13. Kamath R.S., Martinez-Campo M., Zipperlen P., Fraser A.G., and Ahringer J. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2 1 (2001) (Electronic publication ahead of print, 2000 Dec 20)
14. Garbe D., Doto J.B., and Sundaram M.V. Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics 167 (2004) 632-663
15. Goker-Alpan O., Hruska K.S., Orvisky E., Kishnani P.S., Stubblefield B.K., Schiffmann R., and Sidransky E. Divergent phenotypes in Gaucher disease implicate the role of modifiers. J. Med. Genet. 42 (2005) e37
16. WormBase. http://www.wormbase.org accessed Dicember 2007