Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 5846-5859

  Pedragosa Badia, Xavier ^a   Sliwoski, Gregory R ^b   Nguyen, Elizabeth Dong ^b   Lindner, Diana ^a,c   Stichel, Jan ^a   Kaufmann, Kristian W ^b   Meiler, Jens ^b   Beck Sickinger, Annette G ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HEART CENTER HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGONISTIC EFFECTS; BIOLOGICAL FUNCTIONS; COMPARATIVE MODELING; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC INTERACTIONS; PANCREATIC POLYPEPTIDES; STRUCTURAL CHARACTERIZATION; TRANSMEMBRANE HELICES;

AMINO ACIDS; HYDROGEN BONDS; MUTAGENESIS;

HYDROPHOBICITY;

ASPARAGINE; ASPARTIC ACID; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; NEUROPEPTIDE Y4 RECEPTOR; PANCREAS POLYPEPTIDE; PHENYLALANINE; TRANSMEMBRANE HELIX 2; TRANSMEMBRANE HELIX 6; TRANSMEMBRANE HELIX 7; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESIDUE ANALYSIS; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

7-HELIX RECEPTOR; BINDING POCKET; COMPARATIVE MODEL; COMPUTER MODELING; G PROTEIN-COUPLED RECEPTORS (GPCR); MOLECULAR MODELING; NEUROPEPTIDE; PANCREATIC POLYPEPTIDE;

ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PANCREATIC POLYPEPTIDE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NEUROPEPTIDE Y;

EID: 84896841389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.502021     Document Type: Article

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