The suppressive effects of gx-50 on Aβ-induced chemotactic migration of microglia

International Immunopharmacology

Volumn 19, Issue 2, 2014, Pages 283-289

  Guo, Yubing ^a   Shi, Shi ^a   Tang, Maoping ^a   Liang, Dongli ^a   Xu, Wangjie ^a   Wang, Lianyun ^a   Wang, Zhaoxia ^a   Qiao, Zhongdong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Chemotaxis; Microglia; TGF 1 Smad2 pathway

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GLYCOGEN SYNTHASE KINASE 3BETA; GX 50; NOOTROPIC AGENT; RANTES; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL VIABILITY; CHEMOTAXIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; MICROGLIA; MICROGLIAL CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING; ZANTHOXYLUM;

ALZHEIMER'S DISEASE; CHEMOTAXIS; MICROGLIA; TGF-Β1-SMAD2 PATHWAY;

ACRYLAMIDES; AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHEMOTAXIS; GLYCOGEN SYNTHASE KINASE 3; MICROGLIA; PEPTIDE FRAGMENTS; RATS; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84896836383     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.01.025     Document Type: Article

References (30)

1. D.J. Selkoe, and D. Schenk Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu Rev Pharmacol Toxicol 43 2003 545 584
2. M.A. Meraz-Rios, D. Toral-Rios, D. Franco-Bocanegra, J. Villeda-Hernandez, and V. Campos-Pena Inflammatory process in Alzheimer's disease Front Integr Neurosci 7 2013 59
3. E. Solito, and M. Sastre Microglia function in Alzheimer's disease Front Pharmacol 3 2012 14
4. S.T. Dheen, C. Kaur, and E.A. Ling Microglial activation and its implications in the brain diseases Curr Med Chem 14 11 2007 1189 1197
5. A. Cossarizza, R. Ferraresi, L. Troiano, E. Roat, L. Gibellini, and L. Bertoncelli et al. Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry Nat Protoc 4 12 2009 1790 1797
6. M. Tang, Z. Wang, Y. Zhou, W. Xu, S. Li, and L. Wang et al. A novel drug candidate for Alzheimer's disease treatment: gx-50 derived from Zanthoxylum bungeanum J Alzheimers Dis 34 1 2013 203 213
7. W.-C. Huang, F.-C. Yen, Y.-J. Shiao, F.-S. Shie, J.-L. Chan, and C.-N. Yang et al. Enlargement of Aβ aggregates through chemokine-dependent microglial clustering Neurosci Res 63 4 2009 280 287
8. W.C. Huang, F.C. Yen, F.S. Shie, C.M. Pan, Y.J. Shiao, and C.N. Yang et al. TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5 J Neuroinflammation 7 2010 28
9. + regulatory T cell-mediated immunosuppression Cytokine Growth Factor Rev 14 2 2003 85 89
10. R. Peila, B. Yucesoy, L.R. White, V. Johnson, M.L. Kashon, and K. Wu et al. A TGF-β1 polymorphism association with dementia and neuropathologies: the HAAS Neurobiol Aging 28 9 2007 1367 1373
11. F. Caraci, S. Spampinato, M.A. Sortino, P. Bosco, G. Battaglia, and V. Bruno et al. Dysfunction of TGF-beta1 signaling in Alzheimer's disease: perspectives for neuroprotection Cell Tissue Res 347 1 2012 291 301
12. C.J. Yuskaitis, and R.S. Jope Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity Cell Signal 21 2 2009 264 273
13. H. Zeng, Q. Chen, and B. Zhao Genistein ameliorates β-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis Free Radic Biol Med 36 2 2004 180 188
14. S. Caito, Y. Yu, and M. Aschner Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia Neurotoxicology 37 2013 93 99
15. S. Rivest Molecular insights on the cerebral innate immune system Brain Behav Immun 17 1 2003 13 19
16. N. El-Hage, A.J. Bruce-Keller, P.E. Knapp, and K.F. Hauser CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice J Neuroimmune Pharmacol 3 4 2008 275 285
17. I. Tesseur, K. Zou, L. Esposito, F. Bard, E. Berber, and J. Van Can et al. Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer's pathology J Clin Invest 116 11 2006 3060 3069
18. B. Schmierer, and C.S. Hill TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility Nat Rev Mol Cell Biol 8 12 2007 970 982
19. L. Attisano, and J.L. Wrana Smads as transcriptional co-modulators Curr Opin Cell Biol 12 2 2000 235 243
20. J. Massagué, and D. Wotton New EMBO member's review: transcriptional control by the TGF-β/Smad signaling system EMBO J 19 8 2000 1745
21. H.-J. Zhu, and A.W. Burgess Regulation of transforming growth factor-β signaling Mol Cell Biol Res Commun 4 6 2001 321 330
22. S. Itoh, F. Itoh, M.J. Goumans, and P. ten Dijke Signaling of transforming growth factorâ€β family members through Smad proteins Eur J Biochem 267 24 2000 6954 6967
23. M.W. Feinberg, K. Shimizu, M. Lebedeva, R. Haspel, K. Takayama, and Z. Chen et al. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation Circ Res 94 5 2004 601 608
24. + regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10 Cancer Immunol Immunother 56 1 2007 48 59
25. H. Hayashi, S. Abdollah, Y. Qiu, J. Cai, Y.-Y. Xu, and B.W. Grinnell et al. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling Cell 89 7 1997 1165 1173
26. S. Dennler, M.-J. Goumans, and P. ten Dijke Transforming growth factor β signal transduction J Leukoc Biol 71 5 2002 731 740
27. M. Bitzer, G. von Gersdorff, D. Liang, A. Dominguez-Rosales, A.A. Beg, and M. Rojkind et al. A mechanism of suppression of TGF-β/SMAD signaling by NF-κB/RelA Genes Dev 14 2 2000 187 197
28. C.J. Yuskaitis, and R.S. Jope Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity Cell Signal 21 2 2009 264 273
29. W.C. Huang, Y.S. Lin, C.Y. Wang, C.C. Tsai, H.C. Tseng, and C.L. Chen et al. Glycogen synthase kinaseâ€3 negatively regulates antiâ€inflammatory interleukinâ€10 for lipopolysaccharideâ€induced iNOS/NO biosynthesis and RANTES production in microglial cells Immunology 128 1 pt2 2009 e275 e286
30. B. Gui, M. Su, J. Chen, L. Jin, R. Wan, and Y. Qian Neuroprotective effects of pretreatment with propofol in LPS-induced BV-2 microglia cells: role of TLR4 and GSK-3β Inflammation 35 5 2012 1632 1640