Thymoquinone protects renal tubular cells against tubular injury

Cell Biochemistry and Function

Volumn 26, Issue 3, 2008, Pages 374-380

  Saved, Ahmed Amir Radwan ^a  

^a Minia University ^*  (Egypt)

Author keywords

Angiotensin II; NF B; Renal tubular epithelial cells; Thymoquinone

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANGIOTENSIN II; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; THYMOQUINONE;

ARTICLE; CONCENTRATION RESPONSE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE SEVERITY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY INJURY; PRIORITY JOURNAL; RENAL PROTECTION;

ADULT; BENZOQUINONES; CELLS, CULTURED; CYTOPROTECTION; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; NF-KAPPA B; PLASMIDS; PROTEIN BINDING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 42949125024     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1454     Document Type: Article

References (29)

1. Auwardt RB, Mudge SJ, Power DA. Transcription factor NFkappa B in glomerulonephritis. Nephrology 2000; 5: 71-82.
2. Chuang LY, Guh JY. Extracellular signals and intracellular pathways in diabetic nephropathy. Nephrology 2001; 6: 165-172.
3. Cooper ME. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 2001; 44: 1957-1972.
4. Yemeni KKV, Bai W, Khan BV, Medford RM, Natarajan R. Hyperglycemia- induced activation of nuclear transcription factor kappa B in vascular smooth muscle cells. Diabetes 1999; 48: 855-864.
5. Davies MJ, Gordon JL, Gearing AJ, et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 1993; 171: 223-229.
6. Alpers CE, Hudkins KL, Davis CL, et al. Expression of vascular cell adhesion molecule-1 in kidney allograft rejection. Kidney Int 1993; 44: 805-816.
7. Plow EF, D'Souza SE. A role for intercellular adhesion molecule-1 in restenosis. Circulation 1997; 95: 1355-1356.
8. Wolf G, Wenzel U, Burns KD, Harris RC, Stahl RA, Thaiss F. Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors. Kidney Int 2002; 61: 1986-1995.
9. Hernandez-Presa M, Bustos C, Ortego M, et al. Angiotensin- converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation 1997; 95: 1532-1541.
10. Wu L, Iwai M, Li Z, et al. Regulation of I{kappa}B and MCP-1 by angiotensin type 2 receptor-activated SHP-1 in fetal vascular smooth muscle cells. Mol Endocrinol 2004; 18: 666-678.
11. Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ. Ultraviolet light activates NF-kappaB through translational inhibition of I-kappa-B alpha synthesis. J Biol Chem 2004; 279: 34898-34902.
12. Hu J, Nakano H, Sakurai H, Colburn NH. Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis 2004; 25: 1991-2003.
13. Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC. p53 induces NF-kappa B activation by an I-kappa B kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem 2004; 279: 26115-26125.
14. Guijarro C, Egido J. Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 2001; 59: 415424.
15. Tahir KE, Ashour MM, al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24: 1123-1131.
16. Swamy SM, Tan BK. Cytotoxic and immunomodulatory effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 2000; 70: 1-7.
17. Mahmoud MR, El-Abhar HS, Saleh S. The effect of Nigella sativa oil against the liver damage induced by Shistosoma mansoni infection in mice. J Ethnopharmacol 2002; 79: 1-11.
18. Haddad PS, Dépôt M, Settaf A, Chabli A, Cherrah Y. Comparative survey on the medicinal plants most recommended by traditional practitioners in Morocco and Canada. J Herbs Spices Med Plants 2003; 10: 2545.
19. Bierhaus A, Schiekofer S, Schwaninger M, et al. Diabetes-associated sustained activation of the transcription factor nuclear factor-κB. Diabetes 2001; 50: 2792-2808.
20. Sens DA, Detrisac CJ, Sens MA, Rossi MR, Wenger SL, Todd JH. Tissue culture of human renal epithelial cells using a defined serum-free growth formulation. Exp Nephrol 1999; 7: 344-352.
21. Hofmann M, Schiekofer S, Kanitz M, et al. Insufficient glycemic control increases NF-κB binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. Diabetes Care 1998; 21: 1310-1316.
22. Schmidt AM, Yan SD, Stern DM. The dark side of glucose. Nat Med 1995; 1: 002-1004.
23. Yan SD, Schmidt AM, Anderson GM, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 1994; 269: 9889-9897.
24. Bierhaus A, Schiekofer S, Andrassy M, et al. The role of oxidative stress and subsequent NF-κB activation in renal disease. Kidney Blood Press Res 1999; 22: 189-199.
25. Sayed AAR, Morcos M. Thymoquinone decreases AGE induced NF-κB activation in proximal tubular epithelial cells. Phytother Res 2007; 21: 898-899.
26. El Gazzar MA, El Mezayen R, Nicolls MR, Dreskin SC. Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation. Biochim Biophys Acta 2007; 1770: 556-564.
27. Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol 2005; 11: 6684-6688.
28. Khan N, Sharma S, Sultana S. Nigella sativa ameliorates potassium bromate induced early events of carcinogenesis: diminution of oxidative stress. Hum Exp Toxicol 2003; 22: 193-203.
29. Khan N, Sharma S, Sultana S. Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1, 2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response. Redox Rep 2004; 9: 19-28.