Attenuation of high cholesterol-induced oxidative stress in rabbit liver by thymoquinone

European Journal of Gastroenterology and Hepatology

Volumn 22, Issue 7, 2010, Pages 826-834

  Attia, Ahmed ^a   Ragheb, Ahmed ^a   Sylwestrowicz, Thomas ^b   Shoker, Ahmed ^a  

^a ROYAL UNIVERSITY HOSPITAL   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

hyperlipidemia; oxidative stress; rabbit; steatosis; thymoquinone

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HOMOCYSTEINE; INSULIN; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; THYMOQUINONE; UREA; AMINOTRANSFERASE; ANTIOXIDANT; BENZOQUINONE DERIVATIVE; CHOLESTEROL INTAKE; GLUCOSE BLOOD LEVEL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD CELL COUNT; BODY WEIGHT; CHOLESTEROL DIET; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; EXPERIMENTAL RABBIT; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; UREA BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHOLESTEROL INTAKE; COMPLICATION; DRUG EFFECTS; HYPERCHOLESTEROLEMIA; LIVER; METABOLISM; PATHOLOGY; RABBIT;

ANIMALS; ANTIOXIDANTS; BENZOQUINONES; BLOOD GLUCOSE; CHOLESTEROL, DIETARY; FATTY LIVER; FEMALE; HYPERCHOLESTEROLEMIA; INSULIN; LIVER; MALONDIALDEHYDE; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RABBITS; TRANSAMINASES; TRIGLYCERIDES;

EID: 77953997856     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e328336000d     Document Type: Article

References (38)

1. Kainuma M, Fujimoto M, Sekiya N, Tsuneyama K, Cheng C, Takano Y, et al. Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis. J Gastroenterol 2006; 41:971-980.
2. Marra F, Gastaldelli A, Svegliati BG, Tell G, Tiribelli C. Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med 2008; 14:72-81.
3. Konishi M, Iwasa M, Araki J, Kobayashi Y, Katsuki A, Sumida Y, et al. Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. J Gastroenterol Hepatol 2006; 21:1821-1825.
4. Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernandez-Checa JC. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 1995; 48:825-834.
5. Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 1996; 111:1645-1653.
6. Robino G, Parola M, Marra F, Caligiuri A, De Franco RM, Zamara E, et al. Interaction between 4-hydroxy-2,3-alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signaling in hepatic stellate cells. J Biol Chem 2000; 275:40561-40567.
7. Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q, Ren C, et al. Model of nonalcoholic steatohepatitis. Am J Clin Nutr 2004; 79:502-509.
8. Mansour MA. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci 2000; 66:2583-2591.
9. Finking G, Hanke H. Nikolaj Nikolajewitsch Anitschkow (1885-1964) established the cholesterol-fed rabbit as a model for atherosclerosis research. Atherosclerosis 1997; 135:1-7.
10. Gupta PP, Tandon HD, Ramalingaswami V. Cirrhosis of the liver in rabbits induced by a high cholesterol diet-an experimental model. Indian J Med Res 1976; 64:1516-1526.
11. Buyssens N, Kockx MM, Herman AG, Lazou JM, Van den Berg K,Wisse E, Geerts A. Centrolobular liver fibrosis in the hypercholesterolemic rabbit. Hepatology 1996; 24:939-946.
12. Wanless IR, Belgiorno J, Huet PM. Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole. Hepatology 1996; 24:855-864.
13. Enriquez A, Leclercq I, Farrell GC, Robertson G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem Biophys Res Commun 1999; 255:300-306.
14. Raucy JL, Lasker JM, Kraner JC, Salazar DE, Lieber CS, Corcoran GB. Induction of cytochrome P450IIE1 in the obese overfed rat. Mol Pharmacol 1991; 39:275-280.
15. Irizar A, Barnett CR, Flatt PR, Ioannides C. Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat. Eur J Pharmacol 1995; 293:385-393.
16. Gali-Muhtasib H, Roessner A, Schneider-Stock R. Thymoquinone: A promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 2006; 38:1249-1253.
17. Al Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J 2002; 23:1327-1331.
18. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005; 5:1749-1770.
19. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol 2002; 79:23-26. (Pubitemid 34017236)
20. Kapoor R, Prasad K. Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: effect of SOD and catalase. Circ Shock 1994; 43:79-94.
21. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94:2467-2474.
22. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002; 62:1524-1538.
23. Baskol G, Baskol M, Kocer D. Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis. Clin Biochem 2007; 40:776-780. (Pubitemid 46961959)
24. Koruk M, Taysi S, Savas MC, Yilmaz O, Akcay F, Karakok M. Serum levels of acute phase proteins in patients with nonalcoholic steatohepatitis. Turk J Gastroenterol 2003; 14:12-17. (Pubitemid 36569840)
25. Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 1998; 30:225-243.
26. George J, Pera N, Phung N, Leclercq I, Yun HJ, Farrell G. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. J Hepatol 2003; 39:756-764.
27. Fan JG, Zhong L, Xu ZJ, Tia LY, Ding XD, Li MS, Wang GL. Effects of low-calorie diet on steatohepatitis in rats with obesity and hyperlipidemia. World J Gastroenterol 2003; 9:2045-2049.
28. Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA,Woodburne VE, et al. Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J Gastroenterol Hepatol 2003; 18:1272-1282.
29. Thong-Ngam D, Samuhasaneeto S, Kulaputana O, Klaikeaw N. N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World J Gastroenterol 2007; 13:5127-5132.
30. Brody T. Nutritional biochemistry. The United States: Academic Press; 1994.
31. Benzie IF. Lipid peroxidation: A review of causes, consequences, measurement and dietary influences. Int J Food Sci Nutr 1996; 47:233-261.
32. De Knegt RJ. Non-alcoholic steatohepatitis: clinical significance and pathogenesis. Scand J Gastroenterol Suppl 2001; 36:88-92.
33. Day CP. Pathogenesis of steatohepatitis. Best Pract Res Clin Gastroenterol 2002; 16:663-678.
34. Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 1999; 31:273-300.
35. Nagi MN, Mansour MA. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacol Res 2000; 41:283-289.
36. Nagi MN, Alam K, Badary OA, Al Shabanah OA, al Sawaf HA, Al Bekairi AM. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int 1999; 47:153-159.
37. El Gouhary I, Mohamed A, Suleiman S, Benghuzzi H. Comparison of the amelioration effects of two enzyme inducers on the inflammatory process of experimental allergic encephalitis (EAE) using immunohistochemical technique. Biomed Sci Instrum 2005; 41:376-381.
38. Badary OA, Nagi MN, al Shabanah OA, al Sawaf HA, al Sohaibani MO, al Bekairi AM. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol 1997; 75:1356-1361.