Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1841, Issue 4, 2014, Pages 552-562

  Cai, Kai ^a   Lucki, Natasha C ^a,b   Sewer, Marion B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b California Institute for Biomedical Research   (United States)

Author keywords

Adrenal cortex; cAMP; Cortisol; Diacylglycerol kinase theta; Phosphatidic acid

Indexed keywords

3 HYDROXY 3 METHYLGLUTARY COENZYME A; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ACID CERAMIDASE; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE THETA; HYDROCORTISONE; MESSENGER RNA; PHOSPHOLIPASE D; PRASTERONE; SHORT HAIRPIN RNA; STEROID HORMONE; STEROL 14ALPHA DEMETHYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; SF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

ADRENAL CORTEX CELL; ARTICLE; CHOLESTEROL METABOLISM; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEROIDOGENESIS; WESTERN BLOTTING; ADRENAL CORTEX; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIPID METABOLISM; METABOLISM; PHOSPHORYLATION; PROMOTER REGION; SIGNAL TRANSDUCTION;

ADRENAL CORTEX; CELL LINE; CHOLESTEROL; DEHYDROEPIANDROSTERONE; DIACYLGLYCEROL KINASE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; HYDROCORTISONE; LIPID METABOLISM; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 84896821738     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.12.005     Document Type: Article

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