A practical strategy for characterization of the metabolic profile of chiral drugs using combinatory liquid chromatography-mass spectrometric techniques: Application to tetrahydropalmatine enantiomers and their metabolites in rat urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 94, Issue , 2014, Pages 152-162

  Zhang, Yinying ^a   Dong, Xin ^a   Le, Jian ^b   Wen, Jun ^a   Lin, Zebin ^a   Liu, Yinli ^a   Lou, Ziyang ^a   Chai, Yifeng ^a   Hong, Zhanying ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

LC QqQ MS; Metabolites; Rat urine; Tetrahydropalmatine; UPLC QTOF MS

Indexed keywords

GLUCURONIDE; TETRAHYDROPALMATINE;

ANIMAL EXPERIMENT; ARTICLE; CONJUGATION; CORYDALIS; DEMETHYLATION; DRUG METABOLISM; ENANTIOMER; IN VIVO STUDY; KINETICS; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ASSAY; RAT; RHIZOME; STEREOCHEMISTRY; SULFATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINARY EXCRETION; URINE;

LC-QQQ/MS; METABOLITES; RAT URINE; TETRAHYDROPALMATINE; UPLC-QTOF/MS;

ANIMALS; BERBERINE ALKALOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORYDALIS; DRUGS, CHINESE HERBAL; MALE; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84896808330     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.01.045     Document Type: Article

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