Qualitative-(semi)quantitative data acquisition of artemisinin and its metabolites in rat plasma using an LTQ/Orbitrap mass spectrometer

Journal of Mass Spectrometry

Volumn 47, Issue 2, 2012, Pages 246-252

  Du, Fuying ^a   Liu, Tian ^a   Shen, Tao ^a   Zhu, Fanping ^a   Xing, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

artemisinin; HRMS; metabolites; quantitation

Indexed keywords

ANALYTES; ARTEMISININ; AUTOINDUCTION; CALIBRATION CURVES; CONCENTRATION RANGES; DATA SETS; DIASTEREOMERS; EXTRACTED ION CHROMATOGRAM; HIGH EXPOSURES; HIGH RESOLUTION; HRMS; MASS ANALYZERS; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PHASE I; PLASMA SAMPLES; POSITIVE ION MODE; PROTEIN PRECIPITATION; QUANTITATION; QUANTITATIVE DATA; RAT PLASMA; STANDARD CURVES; VALIDATION APPROACH;

ACETONITRILE; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; RATS; SEPARATION;

METABOLISM;

ACETONITRILE; ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; DEOXYARTEMISININ; DIHYDROARTEMISININ; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG STABILITY; LINEAR MODELS; MASS SPECTROMETRY; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

RATTUS;

EID: 84857467328     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.2958     Document Type: Article

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