Difference absorption of l-tetrahydropalmatine and dl-tetrahydropalmatine in intestine of rats

Yaoxue Xuebao

Volumn 42, Issue 5, 2007, Pages 534-537

  Wu, Pei Sheng ^a   Huang, Shan Ding ^b   Ye, Ya Ju ^c   Sun, Si Yuan ^a   Jiang, Hui Di ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NINGBO UNIVERSITY   (China)

^c Yinzhou People's Hospital   (China)

Author keywords

Absorption; in situ single pass intestinal perfusion model; l THF; THF

Indexed keywords

BERBERINE DERIVATIVE; GLYCOPROTEIN P; TETRAHYDROPALMATINE; VERAPAMIL;

ANIMAL; ARTICLE; CHEMISTRY; COLON; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DUODENUM; FEMALE; ILEUM; INTESTINE ABSORPTION; JEJUNUM; MALE; METABOLISM; PERFUSION; PERMEABILITY; RAT; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; BERBERINE ALKALOIDS; COLON; DUODENUM; FEMALE; ILEUM; INTESTINAL ABSORPTION; JEJUNUM; MALE; P-GLYCOPROTEIN; PERFUSION; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; STEREOISOMERISM; VERAPAMIL;

EID: 34547252396     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. The State Pharmacopoeia Committee of the People ' s Republic of China. Pharmacopoeia of the People ' s Republic of China [S]. 2000 ed. Part II. Beijing: Chemical Industry Press, 2000; 216.
2. Sha S. Assay Methods for Active Components in Chinese Herb Medicines [ M ]. Beijing; People's Medical Publishing House, 1985;53.
3. Zhou JH, Wang JH. Advances in Pharmacological and Clinical Research of Traditional Chinese Medicines [M]. Beijing: Chinese Science and Technology Publishing House, 1993;201.
4. Xu T, Jin XL, Cao HM. Advance in research of the pharmacological action of dl-THP [J]. Chin J Clin Pharm, 2001,10:58 -60.
5. Huang K, Dai GZ, Li XH, et al. Blocking L-calcium current by l-terahydropalmatine in single ventricular myocyte of Guinea pigs [ J ]. Acta Pharm Sin, 1999,20:907.
6. Jin GZ. Advances in pharmacology of 2-tetrahydropalmatine and l-stepholidine [J]. Acta Pharm Sin, 1987, 22, 472 -474.
7. Hong ZY, Fan GR, ChaiYF, et al. Stereoselective pharmacokinetics of tetrahydrop-almatine in rats [J]. Acta Pharm Sin, 2005,40:746 -749.
8. Fagerholm U, Johansson M, Lennemas H. Comparison between permeability coefficients in rat and human jejunum [J]. Pharm Res, 1996,13:1336-1342.
9. You J, Li QP, Yu YW, et al. Absorption of zedoary oil in rat intestine using in situ single pass perfusion model [J]. Acta Pharm Sin, 2004, 39,849-853.
10. Sun JY, Zhou ZF, Liu F. Studies on the absorption kinetics of fluorouracil and effect of colon penetration enhancers using perfusion method in rats [ J ]. Chin J Mod Appl Pharm, 2003,20, 386-389.
11. Saitoh H, Aungst BJ. Possible involvement of multiple Pglycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine [J]. Pharm Res, 1995,12:1304-1310.
12. Berggren S, Hoogstraate J, Fagerholm U, et al. Characterization of jejunal absorption and apical efflux of ropivacaine, lidooaine and bupivacaine in the rat using in situ and in vitro absorption models [ J ]. Eur J Pharm Sci, 2004,21:553-560.