Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats

Biomedical Chromatography

Volumn 20, Issue 1, 2006, Pages 95-100

  Li, Li ^a,b   Ye, Min ^a   Bi, Kaishun ^b   Guo, Dean ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Biotransformation; L tetrahydropalmatine; LC MS MS; Metabolism

Indexed keywords

BIOMOLECULES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RATS;

BIOTRANSFORMATION; IN-VIVO; L-TETRAHYDROPALMATINE; LC-MASS SPECTROMETRY/MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MASS SPECTROMETRY ANALYSIS; MICROBIAL METABOLISM; MICROBIAL TRANSFORMATION; VIVO STUDIES;

METABOLITES;

9 O NOR LEVO TETRAHYDROPALMATINE; CORYDALMINE; DRUG METABOLITE; LEVO CORYPALMINE; TETRAHYDROPALMATINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG FECES LEVEL; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIUM JANTHINELLUM; RAT; SEPARATION TECHNIQUE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STEPHANIA; TANDEM MASS SPECTROMETRY; URINARY EXCRETION;

ANIMALIA; MAMMALIA; PENICILLIUM JANTHINELLUM; STEPHANIA;

EID: 31344478233     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.534     Document Type: Article

References (8)

1. Azerad R. Microbial models of mammalian metabolism. Advances in Biochemical Engineering and Biotechnology 1999; 63: 169-218.
2. Chi KL and Albert YWC. Tetrahydropalmatine poisoning: diagnoses of nine adult overdoses based on toxicology screens by HPLC with diode-array detection and gas chromatography-mass spectrometry. Clinical Chemistry 1999; 45: 229-236.
3. Desmet P, Elferink F and Verpoorte R. Left-turning tetrahydropalmatine in Chinese tablets. Nederlands Tijdschrift voor Genees-kunde 1989; 133: 308.
4. Isabelle L, Jacques B and Robert A. Microbial models of drug metabolism: microbial transformations of trimegestone (RU27987), a 3-keto-4,9(10)-19-norsteroid drug. Bioorganic Medical Chemistry 1999; 7: 2329-2341.
5. Moussa C, Houziaux P, Danree B and Azerad R. Microbial models of mammalian metabolism. Fungal metabolism of phenolic and nonphenolic p-cymene-related drugs and prodrugs. I. Metabolites of thymoxamine. Drug Metabolism and Disposition 1997; 25: 301-310.
6. Picciotto A, Campo N, Brizzolara R, Giusto R, Giusto G and Sinelli N. Chronic hepatitis induced by Jin Bu Huan. Journal of Hepatology 1998; 28: 165-167.
7. Smith RV and Rosazza JP. Microbial models of mammalian metabolism, aromatic hydroxylation. Archives of Biochemistry and Biophysics 1974; 161: 551-558.
8. Woolf GM, Petrovic LM, Rojter SE, Wainwright S, Villamil FG and Katkov WN. Acute hepatitis associated with the Chinese herbal product Jin Bu Huan. Annals of Internal Medicine 1994; 121: 729-735.