Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro

Journal of Chromatography A

Volumn 1217, Issue 51, 2010, Pages 7942-7948

  Portmann, Simone ^a   Kwan, Hiu Ying ^a   Theurillat, Regula ^a   Schmitz, Andrea ^a   Mevissen, Meike ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Capillary electrophoresis; CYP2A6; CYP2B6; CYP3A4; Ketamine; Norketamine; Pharmacokinetics; Stereoselective metabolism

Indexed keywords

CYP2A6; CYP2B6; CYP3A4; KETAMINE; NORKETAMINE; STEREO-SELECTIVE;

ANESTHETICS; BIOCONVERSION; BLOOD VESSELS; CAPILLARY ELECTROPHORESIS; CATALYSTS; DRUG DOSAGE; ELECTROCHEMISTRY; ENZYMES; HYDROXYLATION; LIVER; METABOLISM; PHARMACOKINETICS; STEREOSELECTIVITY;

AMINES;

CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; KETAMINE; NORKETAMINE; PHENCYCLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CAPILLARY ELECTROCHROMATOGRAPHY; CONTROLLED STUDY; DEMETHYLATION; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOSELECTIVITY; HILL REACTION; HUMAN; HYDROXYLATION; IN VITRO STUDY; LIVER MICROSOME; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; STEREOCHEMISTRY;

ANALGESICS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, CAPILLARY; HUMANS; HYDROXYLATION; KETAMINE; KINETICS; MICROSOMES, LIVER; STEREOISOMERISM;

EID: 78649474321     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.06.028     Document Type: Article

References (35)

1. Baselt R.C., Cravey R.H. Disposition of Toxic Drugs and Chemicals in Man 1995, Chemical Toxicology Institute, Foster City, CA, p. 412. 4th ed.
2. Clarke's Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material 2004, 1152. Pharmaceutical Press, London, UK. 3rd ed. A.C. Moffat, M.D. Osselton, B. Widdop, L.Y. Galichet (Eds.).
3. Sinner B., Graf B.M. Handb. Exp. Pharmacol. 2008, 182:313.
4. Craven R. Anaesthesia 2007, 62:48.
5. Mathisen L.C., Skjelbred P., Skoglund L.A., Oye I. Pain 1995, 61:215.
6. Adams H.A., Werner C. Anaesthesist 1997, 46:1026.
7. Cromhout A. Emerg. Med. 2003, 15:155.
8. Huang M.K., Liu C., Li J.H., Huang S.D. J. Chromatogr. B 2005, 820:165.
9. Woolf T.F., Adams J.D. Xenobiotica 1987, 17:839.
10. Kharasch E.D., Labroo R. Anesthesiology 1992, 77:1201.
11. Yanagihara Y., Kariya S., Ohtani M., Uchino K., Aoyama T., Yamamura Y., Iga T. Drug Metab. Dispos. 2001, 29:887.
12. Hijazi Y., Boulieu R. Drug Metab. Dispos. 2002, 30:853.
13. Turfus S.C., Parkin M.C., Cowan D.A., Halket J.M., Smith N.W., Braithwaite R.A., Elliot S.P., Steventon G.B., Kicman A.T. Drug Metab. Dispos. 2009, 37:1769.
14. Schmitz A., Thormann W., Moessner L., Theurillat R., Helmja K., Mevissen M. Electrophoresis 2010, 31:1506.
15. Schmitz A., Theurillat R., Lassahn P.-G., Mevissen M., Thormann W. Electrophoresis 2009, 30:2912.
16. Adams J.D., Baillie T.A., Trevor A.J., Castagnoli N. Biomed. Mass Spectrom. 1981, 8:527.
17. Schmitz A., Portier C.J., Thormann W., Theurillat R., Mevissen M. J. Vet. Pharmacol. Ther. 2008, 31:446.
18. Savchuk S.A., Brodskii E.S., Rudenko B.A., Formanovskii A.A., Mikhura I.V., Davydova N.A. J. Anal. Chem. 1997, 52:1175.
19. Bolze S., Boulieu R. Clin. Chem. 1998, 44:560.
20. Hijazi Y., Bodonian C., Bolon M., Salord F., Boulieu R. Br. J. Anaesth. 2003, 90:155.
21. Lankveld D.P.K., Driessen B., Soma L.R., Moate P.J., Rudy J., Uboh C.E., van Dijk P., Hellebrekers L.J. J. Vet. Pharmacol. Ther. 2006, 29:477.
22. Theurillat R., Knobloch M., Levionnois O., Larenza P., Mevissen M., Thormann W. Electrophoresis 2005, 26:3942.
23. Theurillat R., Knobloch M., Schmitz A., Lassahn P.G., Mevissen M., Thormann W. Electrophoresis 2007, 28:2748.
24. Capponi L., Schmitz A., Thormann W., Theurillat R., Mevissen M. Am. J. Vet. Res. 2009, 70:777.
25. Larenza M.P., Landoni M.F., Levionnois O.L., Knobloch M., Kronen P.W., Theurillat R., Schatzmann U., Thormann W. Br. J. Anaesth. 2007, 98:204.
26. Larenza M.P., Knobloch M., Landoni M.F., Levionnois O.L., Kronen P.W., Theurillat R., Schatzmann U., Thormann W. Vet. J. 2008, 177:432.
27. Knobloch M., Portier C.J., Levionnois O.L., Theurillat R., Thormann W., Spadavecchia C., Mevissen M. Toxicol. Appl. Pharmacol. 2006, 216:373.
28. Peterbauer C., Larenza M.P., Knobloch M., Theurillat R., Thormann W., Mevissen M., Spadavecchia C. Vet. Anaesth. Analg. 2008, 35:414.
29. Larenza M.P., Peterbauer C., Landoni M.F., Levionnois O.L., Schatzmann U., Spadavecchia C., Thormann W. Am. J. Vet. Res. 2009, 70:831.
30. Wojcikowski J., Pichard-Garcia L., Maurel P., Daniel W.A. Eur. Neuropsychopharmacol. 2004, 14:199.
31. Houston J.B., Kenworthy K.E. Drug Metab. Dispos. 2000, 28:246.
32. Tracy T.S., Hummel M.A. Drug Metab. Rev. 2004, 36:231.
33. Turpeinen M., Raunio H., Pelkonen O. Curr. Drug Metab. 2006, 7:705.
34. Gerber J.G., Rhodes R.J., Gal J. Chirality 2004, 16:36.
35. Totah R.A., Sheffels P., Roberts T., Whittington D., Thummel K., Kharasch E.D. Anesthesiology 2008, 108:363.