Study on the stereoselective excretion of tetrahydropalmatine enantiomers in rats and identification of in vivo metabolites by liquid chromatography- tandem mass spectrometry

Chirality

Volumn 22, Issue 3, 2010, Pages 355-360

  Hong, Zhanying ^a   Wen, Jun ^a   Zhang, Quanlong ^b   Fan, Guorong ^a   Chai, Yifeng ^a   Wu, Yutian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Enantiomers; Excretion; Metabolite elucidation; Stereoselectivity; Tetrahydropalmatine

Indexed keywords

ANALGESIC AGENT; HYPNOTIC AGENT; O DEMETHYLASE; SEDATIVE AGENT; TETRAHYDROPALMATINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; BLOOD LEVEL; CONTROLLED STUDY; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPNOSIS; LIQUID CHROMATOGRAPHY; MALE; MEDICINAL PLANT; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; RHIZOMA CORYDALIS; SEDATION; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY; URINARY EXCRETION;

ANIMALS; BERBERINE ALKALOIDS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 75849155201     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20750     Document Type: Article

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