The role of renal proximal tubular cells in diabetic nephropathy

Current Diabetes Reports

Volumn 3, Issue 6, 2003, Pages 491-496

  Phillips, Aled O ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; GLUCOSE TRANSPORTER 1; HYALURONIC ACID; INSULIN; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DIABETIC NEPHROPATHY; DISEASE COURSE; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; INFLAMMATORY CELL; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY CELL; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY PROXIMAL TUBULE; MACROPHAGE MIGRATION; MYOFIBROBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW;

EID: 3142705848     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-003-0013-1     Document Type: Review

References (73)

1. Andersen AR, Christiansen SJ, Andersen JK, et al.: Diabetic nephropathy in type 1 diabetes: an epidemiological study. Diabetologia 1983, 25:496-501.
2. Ruggenenti P, Remuzzi G: Nephropathy of type-2 diabetes mellitus. J Am Soc Nephrol 1998, 9:2157-2169.
3. Chihara J, Takegayashi S, Taguchi T, et al.: Glomerulonephritis in diabetic patients and its effect on the prognosis. Nephron 1986, 43:45-49.
4. Mauer SM, Steffes MW, Ellis EE, et al.: Structural-functional relationships in diabetic nephropathy. J Clin Invest 1984, 74:1143-1155.
5. Bohle A, Wehrmann M, Bogenschutz O, et al.: The pathogenesis of chronic renal failure in diabetic nephropathy. Pathol Res Pract 1991, 187:251-259.
6. Parving HH: Renoprotection in diabetes: genetic and nongenetic risk factors and treatment. Diabetologia 1998, 41:745-759.
7. Ritz E, Stefanski A: Diabetic nephropathy in type II diabetes. Am J Kidney Dis 1996, 27:167-194.
8. Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Research Group [no authors listed]. Kidney Int 1995, 47:1703-1720.
9. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. UK Prospective Diabetes Study Group [no authors listed]. Lancet 1998, 352:837-853.
10. Alaveras AE, Thomas SM, Sagriotis A, Viberti GC: Promoters of progression of diabetic nephropathy: the relative roles of blood glucose and blood pressure control. Nephrol Dial Transplant 1997, 12:71-74.
11. Mulec H, Blohme G, Grande B, Bjorck S: The effect of metabolic control on rate of decline in renal function in insulin-dependent diabetes mellitus with overt diabetic nephropathy. Nephrol Dial Transplant 1998, 13:651-655.
12. Bank N, Aynedjian HS: Progressive increases in luminal glucose stimulate proximal sodium adsorption in normal and diabetic rats. J Clin Invest 1990, 86:309-316.
13. Burg M, Patlak N, Green N, Villey D: Organic solutes in fluid absorption by renal proximal convoluted tubules. Am J Physiol 1976, 231:627-637.
14. Kumar AM, Gupta RK, Spitzer A: Intracellular sodium in proximal tubules of diabetic rats: role of glucose. Kidney Int 1988, 33:792-797.
15. Pollock CA, Field MJ, Bostrom TE, et al.: Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis. Eur J Physiol 1991, 418:14-17.
16. Brito PL, Fioretto P, Drummond K, et al.: Proximal tubular basement membrane width in insulin-dependent diabetes mellitus. Kidney Int 1998, 53:754-761.
17. Ziyadeh FN, Snipes ER, Watanabe M, et al.: High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 1990, 259:F704-F714.
18. Phillips AO, Morrisey K, Martin J, et al.: Exposure of human renal proximal tubular cells to glucose leads to accumulation of type IV collagen and fibronectin by decreased degradation. Kidney Int 1997, 52:973-984.
19. Morrisey K, Steadman R, Williams JD, Phillips AO: Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent. Kidney Int 1999, 55:160-167.
20. Phillips AO, Morrisey K, Steadman R, Williams JD: Decreased degradation of collagen and fibronectin following exposure of proximal tubular cells to glucose. Exp Nephrol 1999, 7:449-462.
21. Bleyer AJ, Fumo P, Snipes ER, et al.: Polyol pathway mediates high glucose induced collagen synthesis in proximal tubule. Kidney Int 1994, 45:659-666.
22. Ziyadeh FN, Goldfarb S: The renal tubulointerstitium in diabetes mellitus. Kidney Int 1991, 39:464-475.
23. Flath MC, Bylander JE, Sens DA: Variation in sorbitol accumulation and polyol-pathway activity in cultured human proximal tubular cells. Diabetes 1992, 41:1050-1055.
24. Yamamoto T, Nakamura T, Noble NA, et al.: Expression of Transforming growth factor-beta is elevated in human and experimental diabetic nephrophathy. Proc Natl Acad Sci U S A 1993, 90:1814-1818.
25. Phillips AO, Morrisey R, Steadman R, Williams JD: Polarity of stimulation and secretion of TGF-beta1 by proximal tubular cells. Am J Pathol 1997, 150:1101-1111.
26. Phillips AO, Steadman R, Topley N, Williams JD: Elevated D-glucose concentrations modulate TGF-beta1 synthesis by human cultured renal proximal tubular cells: the permissive role of platelet derived growth factor. Am J Pathol 1995, 147:362-374.
27. Phillips AO, Topley N, Steadman R, et al.: Induction of TGF-beta1 synthesis in D-glucose primed human proximal tubular cells: differential stimulation by the macrophage derived pro-inflammatory cytokines IL-1beta and TNFalpha. Kidney Int 1996, 50:1546-1554.
28. Phillips AO, Topley N, Morrisey K, et al.: Basic fibroblast growth factor stimulates the release of pre-formed TGF-beta1 from human proximal tubular cells in the absence of de-novo gene transcription or mRNA translation. Lab Invest 1997, 76:591-600.
29. Fraser DJ, Wakefield L, Phillips AO: Independent regulation of transforming growth factor-[beta]1 transcription and translation by glucose and platelet-derived growth factor. Am J Pathol 2002, 161:1039-1049.
30. Rocco MV, Chen Y, Goldfarb S, Ziyadeh FN: Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule. Kidney Int 1992, 41:107-114.
31. Wang JL, Nister M, Rudloff EB, et al.: Suppression of platelet derived growth factor alpha- and beta-receptor mRNA levels in human fibroblast by SV40 T/t antigen. J Cell Physiol 1996, 166:12-21.
32. Cagiero E, Roth T, Roy S, Lorenzi M: Characteristics and mechanisms of high-glucose induced over-expression of basement membrane components in cultured human endothelial cells. Diabetes 1991, 40:102-110.
33. Cagliero E, Maiello M, Boeri D, Lorenzi M: High glucose increases TGF-beta mRNA in endothelial cells: a mechanism for the altered regulation of basement membrane components? Diabetes 1988, 37:97A.
34. Cagliero E, Maiello M, Boeri D, et al.: Increased expression of basement components in human endothelial cells cultured in high glucose. J Clin Invest 1988, 82:735-738.
35. Cagliero E, Roth T, Taylor AW, Lorenzi M: The effects of high glucose on human endothelial cell growth and gene expression are not mediated by TGF-beta. Lab Invest 1995, 73:667-673.
36. Morrisey K, Evans RA, Wakefield L, Phillips AO: Translational regulation of renal proximal tubular epithelial cell transforming growth factorβ1 generation by insulin. Am J Pathol 2001, 159:1905-1915.
37. Young BA, Johnson RJ, Alpers CE, et al.: Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995, 47:935-944.
38. Sassy-Pringent C, Heudes D, Mandet C, et al.: Early glomerular macrophage recruitment in streptozotocin induced diabetic rats. Diabetes 2000, 49:466-475.
39. Phillips AO, Baboolal K, Riley SG, et al.: Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of NIDDM. Am J Kidney Dis 2001, 37:400-410.
40. Janssen U, Riley SG, Vassiliadou A, et al.: Hypertension superimposed on type II diabetes in GK rats induces progressive nephropathy. Kidney Int 2003, 63:2162-2170.
41. Furuta T, Saito T, Ootaka T, et al.: The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis 1993, 21:480-485.
42. Cuff CA, Kothapalli D, Azonobi I, et al.: The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest 2001, 108:1031-1040.
43. Sampson PM, Rochester CL, Freundlich B, Elias JA: Cytokine regulation of human lung fibroblast hyaluronan production. Evidence for cytokine-regulated hyaluronan (hyaluronic acid) degradation and human lung fibroblast-derived hyaluronidase. J Clin Invest 1992, 90:1492-1503.
44. Hua Q, Knudson CB, Knudson W: Internalisation of hyaluronan by chondrocytes occurs via receptor mediated endocytosis. J Cell Sci 1993, 106:365-375.
45. Lewington AJP, Padanilam BJ, Martin DR, Hammeramn MR: Expression of CD44 in kidney after acute ischemic injury in rats. Am J Physiol 2000, 278:R247-R254.
46. Sibalic V, Fan X, Loffing J, Würthrich RP: Upregulated renal tubular CD44, hyaluronan, and osteopontin in kdkd mice with interstitial nephritis. Nephrol Dial Transplant 1997, 12:1344-1353.
47. Wells A, Larsson E, Hanas E, et al.: Increased hyaluronan in acutely rejecting human kidney grafts. Transplantation 1993, 55:1346-1349.
48. Wells AF, Larsson E, Tengblad A, et al.: The localisation of hyaluronan in normal and rejected human kidneys. Transplantation 1990, 50:240-243.
49. Beck-Schimmer B, Oertli B, Pasch T, Wüthrich RP: Hyaluronan induces monocyte chemoattractant protein-1 expression in renal tubular epithelial cells. J Am Soc Nephrol 1998, 9:2283-2290.
50. Oertli B, Beck-Schimmer B, Fan X, Wüthrich RP: Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-kappa B activating protein-1. J Immunol 1998, 161:3431-3437.
51. Mahadevan P, Larkins RG, Fraser JRE, et al.: Increased hyaluronan production in the glomeruli from diabetic rats: link between glucose induced prostaglandin production and reduced sulphated proteoglycans. Diabetologia 1995, 38:298-305.
52. Dunlop ME, Clark S, Mahadevan P, et al.: Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet derived growth factor. Kidney Int 1996, 50:40-44.
53. Jones SG, Jones S, Phillips AO: Regulation of renal proximal tubular epithelial cell hyaluronan generation: implications for diabetic nephropathy. Kidney Int 2001, 59:1739-1749.
54. Jones SG, Ito T, Phillips AO: Regulation of proximal tubular epithelial cell CD44 mediated binding and internalisation of hyaluronan. Int J Biochem Cell Biol 2003, 35:1361-1377.
55. Pagtalunan ME, Millar PL, Eagle SJ, et al.: Podocyte loss and progressive glomerular injury in type 2 diabetes. J Clin Invest 1997, 99:342-348.
56. White KE, Bilous RW, Marshall SM, et al.: Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002, 51:3083-3089.
57. Meyer TW, Bennett PH, Nelson RG: Podocyte number predicts long term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria. Diabetologia 1999, 42:1341-1344.
58. Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int 1998, 54:687-697.
59. Essawy M, Soylemezoglu O, Muchaneta-Kubara EC, et al.: Myofibroblasts and the progression of diabetic nephropathy. Nephrol Dial Transplant 1997, 12:43-50.
60. Iwano M, Plieth D, Danoff TM, et al.: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002, 110:341-350.
61. Rastaldi MP, Ferrario F, Giardino L, et al.: Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 2002, 62:137-146.
62. Strutz F, Okada H, Lo CW, et al.: Identification and characterisation of a fibroblast marker: FSP1. J Cell Biol 1995, 130:393-405.
63. Strutz F: Novel aspects of renal fibrogenesis. Nephrol Dial Transplant 1995, 10:1526-1532.
64. Ng YY, Huang TP, Yang WC, et al.: Tubular epithelial myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 1998, 54:864-876.
65. Tian YC, Fraser DL, Attisano L, Phillips AO: TGF-beta1 mediated alterations renal proximal tubular epithelial cell phenotype. Am J Physiol Renal Physiol 2003, 285:F130-F142.
66. Tian YC, Phillips AO: TGF-beta1 mediated inhibition of HK-2 cell migration. J Am Soc Nephrol 2003, 14:631-640.
67. Miao H, Li S, Hu YL, et al.: Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signalling. J Cell Sci 2002, 115:2199-2206.
68. Zeisberg M, Bonner G, Maeshima Y, et al.: Collagen composition and assembly regulates epithelial mesenchymal transdifferentiation. Am J Pathol 2001, 159:1313-1321.
69. Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001, 159:1465-1475.
70. Dumont N, Bakin A, Arteaga CL: Autocrine TGF-beta signalling mediates Smad-independent motility in human cancer cells. J Biol Chem 2003, 278:3275-3285.
71. Yang J, Shultz RW, Mars WM, et al.: Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 2002, 110:1525-1538.
72. Zeisberg M, Maeshima Y, Mosterman B, Kalluri R: Renal fibrosis: extracellular matrix microenvironment regulates migratory behaviour of activated tubular epithelial cells. Am J Pathol 2002, 160:2001-2008.
73. Okada H, Danoff TM, Kalluri R, Neilson EG: Early role of Fsp1 in epithelial mesenchymal transformation. Am J Physiol 1997, 273:F563-F574.