Quick nuclear transportation of siRNA and in vivo hepatic ApoB gene silencing with galactose-bearing polymeric carrier

Journal of Biotechnology

Volumn 175, Issue 1, 2014, Pages 15-21

  Tachibana, Yoichi ^a   Munisso, Maria Chiara ^a   Kamata, Wakako ^a,b   Kitagawa, Masaru ^c   Harada Shiba, Mariko ^a   Yamaoka, Tetsuji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOYOBO CO LTD   (Japan)

Author keywords

Complexes; Liver targeting; SiRNA; Suppression

Indexed keywords

2-(DIMETHYLAMINO)ETHYL METHACRYLATE; APOLIPOPROTEIN B (APOB); CARDIO-VASCULAR DISEASE; COMPLEXES; LIVER TARGETING; LOW DENSITY LIPOPROTEINS; SIRNA; SUPPRESSION;

COPOLYMERS; EXPERIMENTS; GENE TRANSFER; LIPOPROTEINS; MOLECULAR BIOLOGY; MOLECULAR WEIGHT;

POLYMERS;

6 O VINYL ADIPOYL GALACTOSE; 6 O VINYL ADIPOYL GLUCOSE; APOLIPOPROTEIN B; COPOLYMER; GALACTOSE; MESSENGER RNA; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOLIPOPROTEIN B GENE; ARTICLE; BLOOD COMPATIBILITY; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGRADATION; GENE; GENE REPRESSION; GENE SILENCING; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RNA TRANSPORT;

COMPLEXES; LIVER TARGETING; SIRNA; SUPPRESSION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOLIPOPROTEINS B; CELL LINE; CELL NUCLEUS; DIET, HIGH-FAT; GALACTOSE; GENE SILENCING; GENE TRANSFER TECHNIQUES; LIVER; METHACRYLATES; MICE; MICE, INBRED C57BL; POLYMERS; RNA, SMALL INTERFERING;

EID: 84896805139     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.01.029     Document Type: Article

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