The effect of polymer architecture, composition, and molecular weight on the properties of glycopolymer-based non-viral gene delivery systems

Biomaterials

Volumn 32, Issue 22, 2011, Pages 5279-5290

  Ahmed, Marya ^a   Narain, Ravin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Architecture of copolymers; Cationic glycopolymers; Gene delivery; Lethal dose50; RAFT polymerization

Indexed keywords

CATIONIC GLYCOPOLYMERS; CATIONIC SEGMENTS; CELLULAR UPTAKE; CRITICAL COMPOSITION; DEGREE OF POLYMERIZATION; DIBLOCK COPOLYMER; DIBLOCKS; DNA CARRIER; DNA CONDENSATION; FACILE SYNTHESIS; GENE DELIVERY; GLYCOPOLYMERS; HELA CELL; LETHAL DOSE50; LOW TOXICITY; MONOMER RATIO; NON-VIRAL GENE DELIVERY; POLYMER ARCHITECTURE; POLYPLEXES; PROTECTING GROUP; RAFT POLYMERIZATION; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SERUM PROTEINS; STATISTICAL COPOLYMERS; SUGAR MOIETY; TRANSFECTION EFFICIENCY;

ARCHITECTURE; BLOCK COPOLYMERS; BODY FLUIDS; CATIONIC POLYMERIZATION; COPOLYMERIZATION; GENE THERAPY; GENE TRANSFER; LIVING POLYMERIZATION; MOLECULAR WEIGHT; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PLASTIC PRODUCTS; POLYDISPERSITY; POLYMERS; PROTEINS; SUGARS; TOXICITY;

GENE EXPRESSION;

CARBOHYDRATE; COPOLYMER; DNA; MONOMER; PLASMA PROTEIN; PROTEIN INTERACTING WITH PROTEIN KINASE C;

ARTICLE; CELL STRAIN HEPG2; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; POLYMERIZATION; PRIORITY JOURNAL; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SYNTHESIS;

CATIONS; DNA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HEP G2 CELLS; HUMANS; LETHAL DOSE 50; MATERIALS TESTING; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PLASMIDS; POLYMERS; POLYSACCHARIDES;

EID: 79956098437     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.082     Document Type: Article

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