Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Weeks, L D ^a   Zentner, G E ^b   Scacheri, P C ^a,b   Gerson, S L ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

base excision repair; double strand breaks; pemetrexed; thymineless death; uracil; uracil DNA glycosylase

Indexed keywords

CISPLATIN; HISTONE H2AX; PEMETREXED; RALTITREXED; THYMIDINE; THYMIDINE TRIPHOSPHATE; URACIL; URACIL DNA GLYCOSIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG SENSITIVITY; ENZYME ACTIVITY; EXCISION REPAIR; GENE EXPRESSION; GROWTH RATE; HUMAN; HUMAN CELL; HYPERSENSITIVITY; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

CELL CYCLE; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GLUTAMATES; GUANINE; HUMANS; NEOPLASMS; URACIL; URACIL-DNA GLYCOSIDASE;

EID: 84896791375     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.477     Document Type: Article

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