A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 7109-7120

  Inoue, Akira ^a   Kikuchi, Sotaro ^b   Hishiki, Asami ^b   Shao, Youming ^a   Heath, Richard ^a   Evison, Benjamin J ^a   Actis, Marcelo ^a   Canman, Christine E ^c   Hashimoto, Hiroshi ^b,d   Fujii, Naoaki ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; DNA; FREE RADICALS; MOLECULES; PLATINUM COMPOUNDS;

CANCER CELLS; CIS-PLATIN; DNA DOUBLE STRAND BREAKS; PROLIFERATING CELL NUCLEAR ANTIGENS; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

REPAIR;

AMINOALCOHOL; ATM PROTEIN; BINDING PROTEIN; BRCA1 PROTEIN; CISPLATIN; CYCLINE; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE REV1; DOUBLE STRANDED DNA; PROLIFERATING CELL NUCLEAR ANTIGEN INTERACTING PROTEIN BOX; PROTEIN P53 BINDING PROTEIN 1; T2 AMINOALCOHOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHEMOSENSITIVITY; CHROMATIN; CLONOGENIC ASSAY; COMET ASSAY; CONTROLLED STUDY; DNA CROSS LINKING; DNA REPAIR; DNA STRAND BREAKAGE; DNA SYNTHESIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; UBIQUITINATION;

CRYSTALLOGRAPHY; DNA DAMAGE; INTERSTRAND CROSS-LINK; PCNA; SMALL MOLECULES; STRUCTURAL BIOLOGY; UBIQUITINATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CERCOPITHECUS AETHIOPS; CISPLATIN; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; HELA CELLS; HUMANS; NEOPLASMS; PHENYL ETHERS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROPANOLAMINES; SMALL MOLECULE LIBRARIES;

EID: 84896760723     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.520429     Document Type: Article

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