Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1972-1977

  Actis, Marcelo ^a   Inoue, Akira ^a   Evison, Benjamin ^a   Perry, Scott ^a   Punchihewa, Chandanamali ^a   Fujii, Naoaki ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Chemosensitization; DNA damage; PCNA; Protein protein interaction inhibitor; Translesion DNA synthesis

Indexed keywords

BROXURIDINE; CELL DNA; CISPLATIN; CYCLINE; HISTONE H2AX; PCNA INTERACTING PROTEIN BOX; PROTEIN INHIBITOR; T2AA DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; DRUG STRUCTURE; EXCISION REPAIR; FLUORESCENCE POLARIZATION; HELA CELL; IC 50; PLASMID; PROTEIN INDUCTION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DNA; DNA DAMAGE; DNA REPLICATION; HELA CELLS; HUMANS; NEOPLASMS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN INTERACTION MAPS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875223664     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.022     Document Type: Article

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