Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 40043-40050

  Veverka, Vaclav ^a,c   Baker, Terry ^b   Redpath, Nicholas T ^b   Carrington, Bruce ^b   Muskett, Frederick W ^a   Taylor, Richard J ^b   Lawson, Alastair D G ^b   Henry, Alistair J ^b   Carr, Mark D ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES;

FUNCTIONAL SITES; INTERLEUKIN-6; SEQUENCE COMPARISONS; SIGNALING COMPLEX; THERAPEUTIC INTERVENTION;

SIGNALING;

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; GLYCOPROTEIN GP 130; IL6 PROTEIN, HUMAN; IL6R PROTEIN, HUMAN; IL6ST PROTEIN, HUMAN; INTERLEUKIN 6 RECEPTOR; MULTIPROTEIN COMPLEX;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOKINE RELEASE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; ANIMAL; CHEMISTRY; GENETICS; INFLAMMATION; METABOLISM; METHODOLOGY; MOLECULAR EVOLUTION; MOUSE; PEPTIDE MAPPING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

ANIMALS; BINDING SITES; CYTOKINE RECEPTOR GP130; EVOLUTION, MOLECULAR; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICE; MULTIPROTEIN COMPLEXES; PEPTIDE MAPPING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; SEQUENCE ALIGNMENT;

EID: 84873961029     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.405597     Document Type: Article

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