Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn

Biopolymers

Volumn 101, Issue 5, 2014, Pages 484-495

  Baranczak, Aleksandra ^a   Connelly, Stephen ^a   Liu, Yu ^a   Choi, Sungwook ^a,b   Grimster, Neil P ^a,c   Powers, Evan T ^a   Wilson, Ian A ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Chungnam National University   (South Korea)

^c ASTRAZENECA   (United Kingdom)

Author keywords

environmentally sensitive fluorophores; fluorescence switching; reaction regulated quenching functional groups

Indexed keywords

BINDING ENERGY; CHROMOPHORES; FLUORESCENCE; FUNCTIONAL GROUPS; MOLECULES; PROTEINS;

BIOLOGICAL ENVIRONMENTS; CHEMOSELECTIVE REACTIONS; ENVIRONMENTALLY SENSITIVE; FLUORESCENCE SWITCHING; IRREVERSIBLE REACTIONS; LOWEST UNOCCUPIED MOLECULAR ORBITAL; NEW CHEMICAL ENTITIES; NONCOVALENT BINDING;

FLUOROPHORES;

1,3,4 OXADIAZOLE DERIVATIVE; FLUORESCENT DYE; FUNCTIONAL GROUP; INDOLE; PROTEIN; STILBENE; TRYPTOPHAN; LIGAND; PREALBUMIN; SOLVENT; STILBENE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CONJUGATE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON; ENERGY; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN CHEMISTRY; MOLECULAR DYNAMICS; MOLECULAR IMAGING; PHOTOCHEMICAL QUENCHING; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SYNTHESIS; CHEMISTRY; METABOLISM; MOLECULAR MODEL; SPECTROFLUOROMETRY; THERMODYNAMICS; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; FLUORESCENT DYES; IMAGING, THREE-DIMENSIONAL; LIGANDS; MODELS, MOLECULAR; PREALBUMIN; SOLVENTS; SPECTROMETRY, FLUORESCENCE; STILBENES; THERMODYNAMICS; TRYPTOPHAN;

EID: 84896726947     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22407     Document Type: Article

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