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Volumn 28, Issue 2, 2014, Pages 341-354

Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors

Author keywords

Adhesion; Endothelium; Integrins; Selectins; Sickle cell disease

Indexed keywords

ASELIZUMAB; BIMOSIAMOSE; E SELECTIN INHIBITOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GI 270384; L SELECTIN; L SELECTIN INHIBITOR; PAN SELECTIN INHIBITOR; RIVIPANSEL; SELECTIN; SELECTIN ANTAGONIST; UNCLASSIFIED DRUG; GLYCOLIPID; GMI-1070;

EID: 84896725390     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2013.11.010     Document Type: Review
Times cited : (51)

References (50)
  • 1
    • 0025917249 scopus 로고
    • Acarbohydrate domain common to both sialyl Lea and sialyl Lex is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1
    • Berg E., Robinson M.K., Mansson O., et al. Acarbohydrate domain common to both sialyl Lea and sialyl Lex is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. JBiol Chem 1991, 266(23):14869-14872.
    • (1991) JBiol Chem , vol.266 , Issue.23 , pp. 14869-14872
    • Berg, E.1    Robinson, M.K.2    Mansson, O.3
  • 2
    • 0029095952 scopus 로고
    • The selectins: vascular adhesion molecules
    • Tedder T., Steeber D., Chen A., et al. The selectins: vascular adhesion molecules. FASEB J 1995, 9(10):866-873.
    • (1995) FASEB J , vol.9 , Issue.10 , pp. 866-873
    • Tedder, T.1    Steeber, D.2    Chen, A.3
  • 3
    • 38649105208 scopus 로고    scopus 로고
    • Adhesion molecules and receptors
    • Smith C.W. Adhesion molecules and receptors. JAllergy Clin Immunol 2008, 121(Suppl 2):S375-S379.
    • (2008) JAllergy Clin Immunol , vol.121 , Issue.SUPPL 2
    • Smith, C.W.1
  • 4
    • 0029042710 scopus 로고
    • L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    • Tedder T.F., Steeber D.A., Pizcueta P. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. JExp Med 1995, 181(6):2259-2264.
    • (1995) JExp Med , vol.181 , Issue.6 , pp. 2259-2264
    • Tedder, T.F.1    Steeber, D.A.2    Pizcueta, P.3
  • 5
    • 79959609564 scopus 로고    scopus 로고
    • Interactions between endothelial selectins and cancer cells regulate metastasis
    • St Hill C.A. Interactions between endothelial selectins and cancer cells regulate metastasis. Front Biosci 2011, 17:3233-3251.
    • (2011) Front Biosci , vol.17 , pp. 3233-3251
    • St Hill, C.A.1
  • 7
    • 84862123397 scopus 로고    scopus 로고
    • E-selectin ligands as mechanosensitive receptors on neutrophils in health and disease
    • Chase S., Magnani J., Simon S. E-selectin ligands as mechanosensitive receptors on neutrophils in health and disease. Ann Biomed Eng 2012, 40(4):849-859.
    • (2012) Ann Biomed Eng , vol.40 , Issue.4 , pp. 849-859
    • Chase, S.1    Magnani, J.2    Simon, S.3
  • 8
    • 0030463174 scopus 로고    scopus 로고
    • L-selectin activates the Ras pathway via the tyrosine kinase p56lck
    • Brenner B., Gulbins E., Schlottmann K., et al. L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci USA 1996, 24(26):15376-15381.
    • (1996) Proc Natl Acad Sci USA , vol.24 , Issue.26 , pp. 15376-15381
    • Brenner, B.1    Gulbins, E.2    Schlottmann, K.3
  • 9
    • 0033624253 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    • Kaul D.K., Hebbel R.P. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. JClin Invest 2000, 106(3):411-420.
    • (2000) JClin Invest , vol.106 , Issue.3 , pp. 411-420
    • Kaul, D.K.1    Hebbel, R.P.2
  • 10
    • 77956582086 scopus 로고    scopus 로고
    • GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
    • Chang J., Patton J.T., Sarkar A., et al. GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 2010, 116(10):1779-1786.
    • (2010) Blood , vol.116 , Issue.10 , pp. 1779-1786
    • Chang, J.1    Patton, J.T.2    Sarkar, A.3
  • 11
    • 54049118456 scopus 로고    scopus 로고
    • Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium
    • Zennadi R., Chien A., Xu K., et al. Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. Blood 2008, 112(8):3474-3483.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3474-3483
    • Zennadi, R.1    Chien, A.2    Xu, K.3
  • 12
    • 0032845974 scopus 로고    scopus 로고
    • Neutrophil activation in sickle cell disease
    • Lard L.R., Mul F.P., de Haas M., et al. Neutrophil activation in sickle cell disease. JLeukoc Biol 1999, 66(3):411-415.
    • (1999) JLeukoc Biol , vol.66 , Issue.3 , pp. 411-415
    • Lard, L.R.1    Mul, F.P.2    de Haas, M.3
  • 13
    • 0036757797 scopus 로고    scopus 로고
    • Relationship between the clinical manifestations of sickle cell disease and the expression of adhesion molecules on white blood cells
    • Okpala I., Daniel Y., Haynes R., et al. Relationship between the clinical manifestations of sickle cell disease and the expression of adhesion molecules on white blood cells. Eur J Haematol 2002, 69(3):135-144.
    • (2002) Eur J Haematol , vol.69 , Issue.3 , pp. 135-144
    • Okpala, I.1    Daniel, Y.2    Haynes, R.3
  • 14
    • 84880294481 scopus 로고    scopus 로고
    • Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia
    • Faulcon L.M., Fu Z., Dulloor P., et al. Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia. Br J Haematol 2013, 162(3):421-424.
    • (2013) Br J Haematol , vol.162 , Issue.3 , pp. 421-424
    • Faulcon, L.M.1    Fu, Z.2    Dulloor, P.3
  • 15
    • 53449095364 scopus 로고    scopus 로고
    • L-selectin gene polymorphisms and complications of sickle cell disease
    • Ugochukwu C.C., Okpala I., Pantelidis P., et al. L-selectin gene polymorphisms and complications of sickle cell disease. Int J Lab Hematol 2008, 30(4):312-316.
    • (2008) Int J Lab Hematol , vol.30 , Issue.4 , pp. 312-316
    • Ugochukwu, C.C.1    Okpala, I.2    Pantelidis, P.3
  • 16
    • 0032873984 scopus 로고    scopus 로고
    • Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy
    • Saleh A.W., Hillen H.F., Duits A.J. Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol 1999, 102(1):31-37.
    • (1999) Acta Haematol , vol.102 , Issue.1 , pp. 31-37
    • Saleh, A.W.1    Hillen, H.F.2    Duits, A.J.3
  • 17
    • 0036530221 scopus 로고    scopus 로고
    • Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia
    • Benkerrou M., Delarche C., Brahimi L., et al. Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia. Blood 2002, 99(7):2297-2303.
    • (2002) Blood , vol.99 , Issue.7 , pp. 2297-2303
    • Benkerrou, M.1    Delarche, C.2    Brahimi, L.3
  • 18
    • 0037022684 scopus 로고    scopus 로고
    • Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm
    • Turhan A., Weiss L.A., Mohandas N., et al. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci USA 2002, 99(5):3047-3051.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.5 , pp. 3047-3051
    • Turhan, A.1    Weiss, L.A.2    Mohandas, N.3
  • 19
    • 84896694233 scopus 로고    scopus 로고
    • Sickle red blood cell induced adhesion of neutrophils to endothelial cells and biologic correlates of leukocyte activation
    • Boateng L.A., Zennadi R., Telen M.J. Sickle red blood cell induced adhesion of neutrophils to endothelial cells and biologic correlates of leukocyte activation. Blood 2011, 118:1055.
    • (2011) Blood , vol.118 , pp. 1055
    • Boateng, L.A.1    Zennadi, R.2    Telen, M.J.3
  • 20
    • 0035117938 scopus 로고    scopus 로고
    • Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells
    • Brown M.D., Wick T.M., Eckman J.R. Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells. Pediatr Pathol Mol Med 2001, 20(1):47-72.
    • (2001) Pediatr Pathol Mol Med , vol.20 , Issue.1 , pp. 47-72
    • Brown, M.D.1    Wick, T.M.2    Eckman, J.R.3
  • 21
    • 0032533627 scopus 로고    scopus 로고
    • Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes
    • Sultana C., Shen Y., Rattan V., et al. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes. Blood 1998, 92(10):3924-3935.
    • (1998) Blood , vol.92 , Issue.10 , pp. 3924-3935
    • Sultana, C.1    Shen, Y.2    Rattan, V.3
  • 22
    • 0034658663 scopus 로고    scopus 로고
    • Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells
    • Shiu Y.T., Udden M.M., McIntire L.V. Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells. Blood 2000, 95(10):3232-3241.
    • (2000) Blood , vol.95 , Issue.10 , pp. 3232-3241
    • Shiu, Y.T.1    Udden, M.M.2    McIntire, L.V.3
  • 23
    • 0034307274 scopus 로고    scopus 로고
    • Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion
    • Belcher J.D., Marker P.H., Weber J.P., et al. Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion. Blood 2000, 96(7):2451-2459.
    • (2000) Blood , vol.96 , Issue.7 , pp. 2451-2459
    • Belcher, J.D.1    Marker, P.H.2    Weber, J.P.3
  • 24
    • 84857050372 scopus 로고    scopus 로고
    • Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-kappaB signaling pathway
    • Safaya S., Steinberg M.H., Klings E.S. Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-kappaB signaling pathway. Mol Immunol 2012, 50(1-2):117-123.
    • (2012) Mol Immunol , vol.50 , Issue.1-2 , pp. 117-123
    • Safaya, S.1    Steinberg, M.H.2    Klings, E.S.3
  • 25
    • 64149108317 scopus 로고    scopus 로고
    • Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
    • Hidalgo A., Chang J., Jang J.E., et al. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 2009, 15(4):384-391.
    • (2009) Nat Med , vol.15 , Issue.4 , pp. 384-391
    • Hidalgo, A.1    Chang, J.2    Jang, J.E.3
  • 26
    • 84952982277 scopus 로고    scopus 로고
    • GMI-1070: a small pan-selectin antagonist that inhibits leukocyte adhesion and migration in multiple disease models invivo
    • Magnani J.L., Sarkar A., Li Y., et al. GMI-1070: a small pan-selectin antagonist that inhibits leukocyte adhesion and migration in multiple disease models invivo. Blood (ASH Annual Meeting Abstracts) 2007, 110(11):2410.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , Issue.11 , pp. 2410
    • Magnani, J.L.1    Sarkar, A.2    Li, Y.3
  • 27
    • 84896722955 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of GMI-1070, a pan-selectin inhibitor for treatment of vaso-occlusive crisis: single and multiple dose studies in healthy volunteers
    • Xie Y.L., Seufert R., Magnani J.L., et al. Safety, tolerability and pharmacokinetics of GMI-1070, a pan-selectin inhibitor for treatment of vaso-occlusive crisis: single and multiple dose studies in healthy volunteers. Blood (ASH Annual Meeting Abstracts) 2009, 114:1526.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 1526
    • Xie, Y.L.1    Seufert, R.2    Magnani, J.L.3
  • 28
    • 84864840039 scopus 로고    scopus 로고
    • GMI-1070, a pan-selectin inhibitor: safety and PK in a phase 1/2 study in adults with sickle cell disease
    • Styles L., Wun T., De Castro L.M., et al. GMI-1070, a pan-selectin inhibitor: safety and PK in a phase 1/2 study in adults with sickle cell disease. Blood (ASH Annual Meeting Abstracts) 2010, 116(21):1632.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21 , pp. 1632
    • Styles, L.1    Wun, T.2    De Castro, L.M.3
  • 29
    • 81055131093 scopus 로고    scopus 로고
    • Effects of GMI-1070, a pan-selectin inhibitor, on leukocyte adhesion in sickle cell disease: results from a phase 1/2 study
    • Wun T., De Castro L.M., Styles L., et al. Effects of GMI-1070, a pan-selectin inhibitor, on leukocyte adhesion in sickle cell disease: results from a phase 1/2 study. ASH Annual Meeting Abstracts 2010, 116(21):262.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 262
    • Wun, T.1    De Castro, L.M.2    Styles, L.3
  • 30
    • 84864838791 scopus 로고    scopus 로고
    • Effects of selectin antagonist GMI-1070 on the activation state of leukocytes in sickle cell patients not in crisis
    • Simon S.I., Chase S., Larkin S.K., et al. Effects of selectin antagonist GMI-1070 on the activation state of leukocytes in sickle cell patients not in crisis. Blood (ASH Annual Meeting Abstracts) 2010, 116(21):2672.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21 , pp. 2672
    • Simon, S.I.1    Chase, S.2    Larkin, S.K.3
  • 31
    • 84864848572 scopus 로고    scopus 로고
    • Inhibition of E-selectin inflammatory function by the glycomimetic GMI-1070
    • Simon S.I., Chase S., Thackray H., et al. Inhibition of E-selectin inflammatory function by the glycomimetic GMI-1070. Blood (ASH Annual Meeting Abstracts) 2011, 118(21):851.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 851
    • Simon, S.I.1    Chase, S.2    Thackray, H.3
  • 32
    • 65349104899 scopus 로고    scopus 로고
    • Intravascular immunity: the host-pathogen encounter in blood vessels
    • Hickey M.J., Kubes P. Intravascular immunity: the host-pathogen encounter in blood vessels. Nat Rev Immunol 2009, 9:364-375.
    • (2009) Nat Rev Immunol , vol.9 , pp. 364-375
    • Hickey, M.J.1    Kubes, P.2
  • 33
    • 79952213893 scopus 로고    scopus 로고
    • The paradox of the neutrophil's role in tissue injury
    • Segel G.B., Halterman M.W., Lichtman M.A. The paradox of the neutrophil's role in tissue injury. JLeukoc Biol 2011, 89(3):359-372.
    • (2011) JLeukoc Biol , vol.89 , Issue.3 , pp. 359-372
    • Segel, G.B.1    Halterman, M.W.2    Lichtman, M.A.3
  • 34
    • 84869155711 scopus 로고    scopus 로고
    • Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
    • Winkler I.G., Barbier V., Nowlan B., et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med 2012, 18(11):1651-1657.
    • (2012) Nat Med , vol.18 , Issue.11 , pp. 1651-1657
    • Winkler, I.G.1    Barbier, V.2    Nowlan, B.3
  • 35
    • 84857124598 scopus 로고    scopus 로고
    • Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells
    • Stark F.C., Gurnani K., Sad S., et al. Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells. PloS one 2012, 7(2):e32211.
    • (2012) PloS one , vol.7 , Issue.2
    • Stark, F.C.1    Gurnani, K.2    Sad, S.3
  • 36
    • 77956614939 scopus 로고    scopus 로고
    • Selectins promote tumor metastasis
    • Läubli H., Borsig L. Selectins promote tumor metastasis. Semin Cancer Biol 2010, 20(3):169-177.
    • (2010) Semin Cancer Biol , vol.20 , Issue.3 , pp. 169-177
    • Läubli, H.1    Borsig, L.2
  • 37
    • 84866532947 scopus 로고    scopus 로고
    • Haploinsufficiency of E-selectin ligand-1 is associated with reduced atherosclerotic plaque macrophage content while complete deficiency leads to early embryonic lethality in mice
    • Luo W., Wang H., Guo C., et al. Haploinsufficiency of E-selectin ligand-1 is associated with reduced atherosclerotic plaque macrophage content while complete deficiency leads to early embryonic lethality in mice. Atherosclerosis 2012, 224(2):363-367.
    • (2012) Atherosclerosis , vol.224 , Issue.2 , pp. 363-367
    • Luo, W.1    Wang, H.2    Guo, C.3
  • 38
    • 56149099017 scopus 로고    scopus 로고
    • Anti-selectin therapy for the treatment of inflammatory diseases
    • Rossi B., Constantin G. Anti-selectin therapy for the treatment of inflammatory diseases. Inflamm Allergy Drug Targets 2008, 7(2):85-93.
    • (2008) Inflamm Allergy Drug Targets , vol.7 , Issue.2 , pp. 85-93
    • Rossi, B.1    Constantin, G.2
  • 39
    • 0033852893 scopus 로고    scopus 로고
    • Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin
    • Singbartl K., Ley K. Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin. Crit Care Med 2000, 28(7):2507-2514.
    • (2000) Crit Care Med , vol.28 , Issue.7 , pp. 2507-2514
    • Singbartl, K.1    Ley, K.2
  • 40
    • 33646696898 scopus 로고    scopus 로고
    • Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury
    • Jayle C., Milinkevitch S., Favreau F., et al. Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury. Kidney Int 2006, 69(10):1749-1755.
    • (2006) Kidney Int , vol.69 , Issue.10 , pp. 1749-1755
    • Jayle, C.1    Milinkevitch, S.2    Favreau, F.3
  • 41
    • 80052395355 scopus 로고    scopus 로고
    • Efficacy of the pan-selectin antagonist bimosiamose on ozone-induced airway inflammation in healthy subjects-a double blind, randomized, placebo-controlled, cross-over clinical trial
    • Kirsten A., Watz H., Kretschmar G., et al. Efficacy of the pan-selectin antagonist bimosiamose on ozone-induced airway inflammation in healthy subjects-a double blind, randomized, placebo-controlled, cross-over clinical trial. Pulm Pharmacol Ther 2011, 24(5):555-558.
    • (2011) Pulm Pharmacol Ther , vol.24 , Issue.5 , pp. 555-558
    • Kirsten, A.1    Watz, H.2    Kretschmar, G.3
  • 42
    • 16644369039 scopus 로고    scopus 로고
    • Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines
    • Langer R., Wang M., Stepkowski S.M., et al. Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. JAm Soc Nephrol 2004, 15(11):2893-2901.
    • (2004) JAm Soc Nephrol , vol.15 , Issue.11 , pp. 2893-2901
    • Langer, R.1    Wang, M.2    Stepkowski, S.M.3
  • 43
    • 0035191257 scopus 로고    scopus 로고
    • Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure
    • Nemoto T., Burne M.J., Daniels F., et al. Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure. Kidney Int 2001, 60(6):2205-2214.
    • (2001) Kidney Int , vol.60 , Issue.6 , pp. 2205-2214
    • Nemoto, T.1    Burne, M.J.2    Daniels, F.3
  • 44
    • 0030953364 scopus 로고    scopus 로고
    • Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion
    • Palma-Vargas J.M., Toledo-Pereyra L., Dean R.E., et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. JAm Coll Surg 1997, 185(4):365-372.
    • (1997) JAm Coll Surg , vol.185 , Issue.4 , pp. 365-372
    • Palma-Vargas, J.M.1    Toledo-Pereyra, L.2    Dean, R.E.3
  • 45
    • 84874564716 scopus 로고    scopus 로고
    • Inhaled pan-selectin antagonist bimosiamose attenuates airway inflammation in COPD
    • Watz H., Bock D., Meyer M., et al. Inhaled pan-selectin antagonist bimosiamose attenuates airway inflammation in COPD. Pulm Pharmacol Ther 2013, 26(2):265-270.
    • (2013) Pulm Pharmacol Ther , vol.26 , Issue.2 , pp. 265-270
    • Watz, H.1    Bock, D.2    Meyer, M.3
  • 46
    • 31344431570 scopus 로고    scopus 로고
    • Pan-selectin antagonism improves psoriasis manifestation in mice and man
    • Friedrich M., Bock D., Philipp S., et al. Pan-selectin antagonism improves psoriasis manifestation in mice and man. Arch Dermatol Res 2006, 297(8):345-351.
    • (2006) Arch Dermatol Res , vol.297 , Issue.8 , pp. 345-351
    • Friedrich, M.1    Bock, D.2    Philipp, S.3
  • 47
    • 0036117531 scopus 로고    scopus 로고
    • Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
    • Schon M.P., Krahn T., Schon M., et al. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nat Med 2002, 8(4):366-372.
    • (2002) Nat Med , vol.8 , Issue.4 , pp. 366-372
    • Schon, M.P.1    Krahn, T.2    Schon, M.3
  • 48
    • 35349020929 scopus 로고    scopus 로고
    • Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis
    • Panés J., Aceituno M., Gil F., et al. Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis. Am J Physiol Gastrointest Liver Physiol 2007, 293(4):G739-G748.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , Issue.4
    • Panés, J.1    Aceituno, M.2    Gil, F.3
  • 49
    • 5644300385 scopus 로고    scopus 로고
    • The effect of anti-L-selectin (aselizumab) in multiple traumatized patients-results of a phase II clinical trial
    • Seekamp A., van Griensven M., Dhondt E., et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients-results of a phase II clinical trial. Crit Care Med 2004, 32(10):2021-2028.
    • (2004) Crit Care Med , vol.32 , Issue.10 , pp. 2021-2028
    • Seekamp, A.1    van Griensven, M.2    Dhondt, E.3
  • 50
    • 80051689516 scopus 로고    scopus 로고
    • YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center phase IIa study
    • Gaber A.O., Mulgaonkar S., Kahan B.D., et al. YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center phase IIa study. Clin Transplant 2011, 25(4):523-533.
    • (2011) Clin Transplant , vol.25 , Issue.4 , pp. 523-533
    • Gaber, A.O.1    Mulgaonkar, S.2    Kahan, B.D.3


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