Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion

Journal of the American College of Surgeons

Volumn 185, Issue 4, 1997, Pages 365-372

  Palma Vargas, J M ^a   Toledo Pereyra, L ^a   Dean, R E ^a   Harkema, J M ^a   Dixon, R A F ^a   Kogan, T P ^a  

^a BORGESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIMOSIAMOSE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; LACTATE DEHYDROGENASE; LIVER PROTECTIVE AGENT; MYELOPEROXIDASE; PADGEM PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; NEUTROPHIL; NONHUMAN; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SURVIVAL TIME;

EID: 0030953364     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1072-7515(01)00943-7     Document Type: Article

References (31)

1. Clavien PA, Harvey PRC, and Strasberg SM. Preservation and reperfusion injuries in liver allografts. Transplantation 1992;53:957–978.
2. Toledo-Pereyra LH, and Suzuki S. Neutrophils, cytokines, and adhesion molecules in hepatic ischemia and reperfusion injury. J Am Coll Surg 1994;179:758–762.
3. Jaeschke H. Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990;4:3355–3359.
4. Welbourn CRB, Goldman G, Paterson IS, et al. Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil. Br J Surg 1991;78:651–665.
5. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, and Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation 1993;55:1265–1272.
6. Vollmar B. Menger MD, Glasz J, et al. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury. Am J Physiol 1994;267:G786–G793.
7. Schmeling DJ, Caty MB, Oldham KT, et al. Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery 1989;106:195–202.
8. McMillen MA. Huribal M, and Sumpio B. Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion. Am J Surg 1993;166:557–562.
9. Moore EE, Moore FA, Franciose RJ, et al. The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J Trauma 1994;37:881–887.
10. Romson JL, Hook BG, Kunkel SL, et al. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983;76:1016–1023.
11. Vedder NB, Winn RK, Rice C, et al. Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuate reperfusion injury in the rabbit ear. Proc Natl Acad Sci USA 1990;87:2643–2646.
12. Ma X, Lefer DJ. Lefer AM, and Rothlein R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 1992;86:937–946.
13. Winn RK, Vedder NB, Mihelcic D, et al. The role of adhesion molecules in reperfusion injury. Agents Actions (Suppl.) 1993;41:113–126.
14. Garcia-Criado FJ. Toledo-Pereyra LH, Lopez-Neblina F. et al. Role of P-selectin in total Hepatic ischemia and reperfusion. J Am Coll Surg 1995;181:327–334.
15. Butcher DC. Leukocyte-endothelial cell recognition. Three (or more) steps to specificity and diversity. Cell 1991;67:1033–1036.
16. Carlos TM. and Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994;84:2068–2101.
17. Foxall C, Watson SR, Dowbenko D, et al. The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl-Lewis X oligosaccharide. J Cell Biol 1992;117:895–899.
18. Kogan TP, Dupre B, Beck PJ, et al. Rational design and synthesis of small molecule, nonoligosaccharide selectin inhibitors: (α-D-mannopyranosyloxy) byphenyl-substituted carboxylic acids. J Med Chem 1995;38:4976–4984.
19. Beck PJ. Bjercke R, Tilton RG, et al. Synthetic small molecule selectin inhibitors that inhibit inflammation. (manuscript submitted).
20. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, et al. Physiopathological advantages of portosystemic shunting for studies of total hepatic ischemia and reperfusion injury in the rat. Transplantology 1992;3:96–101.
21. Bradley PP, Priebat DA, Christensen RD, and Rothstein GR. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206–209.
22. Mullane KM, Kraemer R, and Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Meth 1985;14:157–167.
23. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159.
24. Jaeschke H, Farhood A, Bautista AP, et al. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am J Physiol 1993;264:G801–G806.
25. Colleti LM, Kunkel SL, Walz A, et al. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology 1996;23:506–511.
26. Scales WE, Campbell JR, Green ME, and Remick DG. Hepatic ischemia/reperfusion injury: importance of oxidant/tumor necrosis factor interactions. Am J Physiol 1994;267:G1122–G1127.
27. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;79:669–674.
28. Winn RK, Mihelicic D, Veeder NB, et al. Monoclonal antibodies to leukocyte and endothelial adhesion molecules attenuate ischemia-reperfusion injury. Behring Inst Mitt 1993;92:229–237.
29. Mulligan MS, Varani J, Dame MK, et al. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest 1991;88:1396–1406.
30. Mulligan MS, Miyasaka M, Tamatain T, et al. Requirements for L-selectin in neutrophil-mediated lung injury in rats. J Immunol 1994;152:832–840.
31. Musser JH, Fugedi P, and Anderson MB. Carbohydrate-based therapeutics. In: Wolff ME, ed. Burger’s Medicinal Chemistry and Drug Discovery. New York; John Wiley & Sons, Inc.; 1995;901–947.