Pan-selectin antagonism improves psoriasis manifestation in mice and man

Archives of Dermatological Research

Volumn 297, Issue 8, 2006, Pages 345-351

  Friedrich, Markus ^a   Bock, Daniel ^b   Philipp, Sandra ^a   Ludwig, Nina ^a   Sabat, Robert ^a   Wolk, Kerstin ^a   Schroeter Maas, Sabine ^b   Aydt, Ewald ^b   Kang, Sewon ^c   Dam, Tomas Norman ^c   Zahlten, Rainer ^b   Sterry, Wolfram ^a   Wolff, Gerhard ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Revotar Biopharmaceuticals AG   (Germany)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Antagonists; Inflammation; Psoriasis; Selectins

Indexed keywords

BIMOSIAMOSE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; SELECTIN;

ADULT; ANIMAL CELL; ARTICLE; CELL ADHESION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE; THICKNESS; XENOGRAFT;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELL LINE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; EPIDERMIS; FEMALE; HEXANES; HL-60 CELLS; HUMANS; JURKAT CELLS; LEUKOCYTES; MALE; MANNOSE; MICE; MICE, SCID; MIDDLE AGED; P-SELECTIN; PILOT PROJECTS; PSORIASIS; T-LYMPHOCYTES;

EID: 31344431570     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-005-0626-0     Document Type: Article

References (29)

1. Asadullah K, Volk HD, Sterry W (2001) Effects of systemic interleukin-10 therapy on psoriatic skin lesions: histologic, immunohistologic, and molecular biology findings. J Invest Dermatol 116:721-727
2. Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS (2003) Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells. Blood 102:1771-1778
3. Berg EL, Yoshino T, Rott LS, et al. (1991) The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 174:1461-1466
4. Bhushan M, Bleiker TO, Ballsdon A, et al. (2002) Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial. Br J Dermatol 146:824-831
5. Boehncke WH, Sterry W, Hainzl A, Scheffold W, Kaufmann R (1994) Psoriasiform architecture of murine epidermis overlying human psoriatic dermis transplanted onto SCID mice. Arch Dermatol Res 286:325-330
6. Boyman O, Hefti HP, Conrad C, Nickoloff BJ, Suter M, Nestle FO (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and Tumor Necrosis Factor-α. J Exp Med 199:731-736
7. Castellanos Mdel C, Lopez-Giral S, Lopez-Cabrera M, de Landazuri MO (2002) Multiple cis-acting elements regulate the expression of the early T cell activation antigen CD69. Eur J Immunol 32:3108-3117
8. Chu A, Hong K, Berg EL, Ehrhardt RO (1999) Tissue specificity of E- and P-selectin ligands in Th1-mediated chronic inflammation. J Immunol 163:5086-5093
9. Dam TN, Kang S, Nickoloff BJ, Voorhees JJ (1999) 1alpha,25- dihydroxycholecalciferol and cyclosporine suppress induction and promote resolution of psoriasis in human skin grafts transplanted on to SCID mice. J Invest Dermatol 113:1082-1090
10. Fredriksson T, Pettersson U (1978) Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157:238-244
11. 2-Integrin on neutrophils. J Immunol 172:7780-7790
12. Hicks AER, Abbitt KB, Dodd P, Ridger VC, Hellewell PG, Norman KE (2005) The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol 77:59-66
13. Issekutz AC, Issekutz TB (2002) The role of E-selectin, P-selectin, and very late activation antigen-4 in T lymphocyte migration to dermal inflammation. J Immunol 168:1934-1939
14. Kansas GS (1996) Selectins and their ligands: current concepts and controversies. Blood 88:3259-87
15. Knibbs RN, Craig RA, Natsuka S, Chang A, Cameron M, Lowe JB, Stoolman LM (1996) The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in humanT cells. J Cell Biol 133: 911-920
16. Kogan TP, Dupre B, Bui H, et al. (1998) Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis [3-(3-carboxymethylphenyl) -4-(2-alpha-D-mannopyranosyloxy)phenyl] hexane (TBC1269). J Med Chem 41:1099-1111
17. Langer R, Wang M, Stepkowski SM, et al. (2004) Selectin inhibitor bimosiamose prolongs survival of kidney allograft by reduction in intragraft production of cytokines and chemokines. J Am Soc Nephrol 15:2893-2901
18. Ley K (1996) Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc Res 32:733-742
19. Onai Y, Suzuki J, Nishiwaki Y, Gotoh R, et al. (2003) Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury. Eur J Pharmacol 481:217-225
20. Picker LJ, Michie SA, Rott LS, Butcher EC (1990) A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 136:1053-1068
21. Schon MP, Drewniok C, Boehncke WH (2004) Targeting selectin functions in the therapy of psoriasis. Curr Drug Targets Inflamm Allergy 3:163-168
22. Schon MP, Krahn T, Schon M, et al. (2002) Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nat Med 8:366-372
23. Sperandio M, Lange-Sperandio B, Linderkamp O, Leo A (2004) Blocking leukocyte rolling: does it have a role in disease prevention?. Vasc Dis Preven 1:185-195
24. Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-314
25. Terajima S, Higaki M, Igarashi Y, Nogita T, Kawashima M (1998) An important role of tumor necrosis factor-alpha in the induction of adhesion molecules in psoriasis. Arch Dermatol Res 290:246-252
26. Tietz W, Allemand Y, Borges E, von Laer D, Hallmann R, Vestweber D, Hamann A (1998) CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin. J Immunol 161:963-970
27. Toledo-Pereyra LH, Lopez-Neblina F, Reuben JS, Toledo AH, Ward PA (2004) Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-repserfusion. J Invest Surg 17:3030-313
28. Watson SR, Fennie C, Lasky LA (1991) Neutrophil influx into an inflammatory site inhibited by soluble homing receptor-IgG chimaera. Nature 349:164-167
29. Wolk K, Kunz S, Asadullah K, Sabat R (2002) Cutting edge: immune cells as sources and targets of the IL-10 family members?. J Immunol 168:5397-5402