The effect of anti-L-selectin (aselizumab) in multiple traumatized patients - Results of a phase II clinical trial

Critical Care Medicine

Volumn 32, Issue 10, 2004, Pages 2021-2028

  Seekamp, Andreas ^a   Van Griensven, Martijn ^b   Dhondt, Erwin ^c   Diefenbeck, Michael ^d   Demeyer, Ignace ^e   Vundelinckx, Guy ^f   Haas, Norbert ^g   Schaechinger, Ulrich ^h   Wolowicka, Laura ⁱ   Rammelt, Stefan ^j   Stroobants, Jan ^k   Marzi, Ingo ^l   Brambrink, Ansgar M ^m   Dziurdzik, Piotr ⁿ   Ga̧siorowski, Jacek ^o   Redl, Heinz ^p   Beckert, Michael ^r   Khan Boluki, Jasmin ^q  

^a SAARLAND UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d Berufsgenossenschaftliche Unfallklinik Murnau   (Germany)

^e OLV HOSPITAL   (Belgium)

^f DEPARTMENT OF CARDIOLOGY   (Belgium)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^h UNIVERSITY HOSPITAL REGENSBURG   (Germany)

ⁱ Department of Intensive Care   (Poland)

^j UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^k ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^l UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^m UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

ⁿ Wojewodzki Hospital   (Poland)

^o Wojewodzki Hospital   (Poland)

^p LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^q Scil Technology GmbH   (Germany)

^r NONE

more..

Author keywords

Clinical trial; Intensive care; L selectin antibody; Multiple trauma; Neutrophil adhesion; Organ failure

Indexed keywords

ASELIZUMAB; HUDREGG 55; IMMUNOGLOBULIN G4; L SELECTIN; MONOCLONAL ANTIBODY; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ANAPHYLAXIS; ARTICLE; ARTIFICIAL VENTILATION; BELGIUM; BLUNT TRAUMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG MONITORING; DRUG SAFETY; FEMALE; GERMANY; HUMAN; INFECTION; INJURY SCALE; INTENSIVE CARE; LENGTH OF STAY; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PENETRATING TRAUMA; POLAND; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; URINARY TRACT INFECTION;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; L-SELECTIN; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 5644300385     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000142396.59236.F3     Document Type: Article

References (31)

1. Furie MB, Burns MJ, Tancinco MC, et al: E-selectin (endothelial-leukocyte adhesion molecule-1) is not required for the migration of neutrophils across IL-1-stimulated endothelium in vitro. J Immunol 1992; 148: 2395-2404
2. Hakkert BC, Kuijpers TW, Leeuwenberg JF, et al: Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: The contribution of CD 18, ELAM-1, and VLA-4. Blood 1991; 78:2721-2726
3. Luscinskas FW, Cybulsky MI, Kiely JM, et al: Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J Immunol 1991; 146:1617-1625
4. Griffin JD, Spertini O, Ernst TJ, et al: Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol 1990; 145:576-584
5. Kerner T, Ahlers O, Spielmann S, et al: L-selectin in trauma patients: A marker for organ dysfunction and outcome? Eur J Clin Invest 1999; 29:1077-1086
6. Seekamp A, Regel G, Jutila M, et al: The effect of anti-L-selectin (EL-246) on remote lung injury after infrarenal ischemia/reperfusion. Shock 1997; 7:447-454
7. Schlag G, Redl HR, Till GO, et al: Anti-L-selectin antibody treatment of hemorrhagic-traumatic shock in baboons. Crit Care Med 1999; 27:2050-2053
8. Katahira J, Murakami K, Schmalstieg FC, et al: Role of anti-L-selectin antibody in burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 2002; 283: L1043-L1050
9. Rainer TH, Ng MH-L, Lam NY-L, et al: Role of monocyte L-selectin in the development of post-traumatic organ failure. Resuscitation 2001; 51:139-149
10. Martin U, Beckert M: Humanized antibody to L-selectin (BNP 001) in healthy human volunteers. In: 64. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie. Haas NP, Stürmer KM (Eds). Berlin, Springer-Verlag, 2000, pp 578
11. Co MS, Landolfi NF, Nagy JO, et al: Properties and pharmacokinetics of two humanized antibodies specific for L-selectin. Immunotechnol 1999; 4:253-266
12. Civil ID, Schwab CW: The Abbreviated Injury Scale, 1985 revision: A condensed chart for clinical use. J Trauma 1988; 28:87-90
13. Fu H, Berg EL, Tsurushita N, et al: Fine mapping of the epitopes of humanized anti-L-selectin monoclonal antibodies HuDreg-55 and HuDreg-200. Immunol Lett 1997; 59: 71-78
14. Goris RJA, te Boekhorst TPA, Nuytinck JKS, et al: Multiple-organ failure. Generalized autodestructive inflammation. Arch Surg 1985; 120:1109-1115
15. Lefering R, Goris RJA, van Nieuwenhoven EJ, et al: Revision of the multiple organ failure score. Langenbeck's Arch Surg 2002; 387: 14-20
16. Hollander M, Wolfe DA (Eds): Nonparametric Statistical Methods. New York, Wiley, 1973
17. Eppihimer MJ, Granger DN: Ischemia/reperfusion-induced leukocyte-endothelial interactions in post capillary venules. Shock 1997; 8:16-26
18. Tedder TF, Steeber DA, Chen A, et al: The selectins: Vascular adhesion molecules. FASEB J 1995; 9:866-869
19. Maekawa K, Futami S, Nishida M, et al: Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b. J Trauma 1998; 44: 460-468
20. Seekamp A, van Griensven M, Hildebrandt F, et al: The effect of trauma on neutrophil L-selectin expression and sL-selectin serum levels. Shock 2001; 15:254-260
21. Donnelly SC, Haslett C, Dransfield I, et al: Role of selectins in development of adult respiratory distress syndrome. Lancet 1994; 23:215-219
22. Stengel D, Orth M, Tauber R, et al: Shed L-selectin (sCD62L) load in trauma patients. J Surg Res 2001; 99:321-327
23. Seidelin JB, Nielsen OH, Strom J: Soluble L-selectin levels predict survival in sepsis. Intensive Care Med 2002; 28:1613-1618
24. Simons RK, Hoyt DB, Winchell RJ: Elevated selectin levels after severe trauma: A marker for sepsis and organ failure and a potential target for immunomodulatory therapy. J Trauma 1997; 41:653-661
25. Nast-Kolb D, Waydhas C, Gippner-Steppert C: Indicators of the postinflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997; 42:446-453
26. Kuebler WM, Borges J, Sckell A, et al: Role of L-selectin in leukocyte sequestration in lung capillaries in a rabbit model of endotoxemia. Am J Respir Crit Care Med 2000; 161:36-43
27. Carraway MS, Welty-Wolf KE, Kantrow SP, et al: Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. Am J Respir Crit Care Med 1998; 157:938-949
28. Mercer-Jones MA, Heinzelmann M, Peyton JC, et al: Inhibition of neutrophil migration at the site of infection increases remote organ neutrophil sequestration and injury. Shock 1997; 8:193-199
29. Oberholzer A, Keel M, Zellweger R, et al: Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma 2000; 48:932-937
30. Tsang YT, Neelamegham S, Hu Y, et al: Synergy between L-selectin signaling and chemotactic activation during neutrophil adhesion and transmigration. J Immunol 1997; 159:4566-4577
31. McIntyre TM, Modur V, Prescott SM, et al: Molecular mechanisms of early inflammation. Thromb Haemost 1997; 7:302-309