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Volumn 11, Issue 1, 2014, Pages 40-49

Neuregulin as a heart failure therapy and mediator of reverse remodeling

Author keywords

Cardiac remodeling; ErbB2; ErbB3; ErbB4; GGF2; Neuregulin

Indexed keywords

NEU DIFFERENTIATION FACTOR;

EID: 84896725049     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-013-0176-2     Document Type: Article
Times cited : (55)

References (108)
  • 1
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • 1:CAS:528:DyaK2MXps1ams7o%3D 7477375
    • Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature. 1995;378:386-90.
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 2
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: Functions, forms, and signaling strategies
    • DOI 10.1016/S0014-4827(02)00102-7
    • Falls DL. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res. 2003;284:14-30. (Pubitemid 36335807)
    • (2003) Experimental Cell Research , vol.284 , Issue.1 , pp. 14-30
    • Falls, D.L.1
  • 3
    • 84857736151 scopus 로고    scopus 로고
    • BACE1 dependent neuregulin processing: Review
    • 1:CAS:528:DC%2BC38XkslCmtbk%3D 22455478
    • Fleck D, Garratt AN, Haass C, Willem M. BACE1 dependent neuregulin processing: review. Curr Alzheimer Res. 2012;9:178-83.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 178-183
    • Fleck, D.1    Garratt, A.N.2    Haass, C.3    Willem, M.4
  • 4
    • 84877125044 scopus 로고    scopus 로고
    • Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling
    • 1:CAS:528:DC%2BC3sXhtl2jsrnO 23637177
    • Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, et al. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J Neurosci. 2013;33:7856-69.
    • (2013) J Neurosci , vol.33 , pp. 7856-7869
    • Fleck, D.1    Van Bebber, F.2    Colombo, A.3    Galante, C.4    Schwenk, B.M.5    Rabe, L.6
  • 6
    • 84872031728 scopus 로고    scopus 로고
    • Neuregulin in cardiovascular development and disease
    • 1:CAS:528:DC%2BC38XhsFGqtrzE 3752394 23104879
    • Odiete O, Hill MF, Sawyer DB. Neuregulin in cardiovascular development and disease. Circ Res. 2012;111:1376-85.
    • (2012) Circ Res , vol.111 , pp. 1376-1385
    • Odiete, O.1    Hill, M.F.2    Sawyer, D.B.3
  • 8
    • 84879797348 scopus 로고    scopus 로고
    • Time-dependent regulation of neuregulin-1beta/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells
    • 1:CAS:528:DC%2BC3sXmtlartbY%3D 23606057
    • Chen M, Bi LL, Wang ZQ, Zhao F, Gan XD, Wang YG. Time-dependent regulation of neuregulin-1beta/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells. Mol Cell Biochem. 2013;380:67-72.
    • (2013) Mol Cell Biochem , vol.380 , pp. 67-72
    • Chen, M.1    Bi, L.L.2    Wang, Z.Q.3    Zhao, F.4    Gan, X.D.5    Wang, Y.G.6
  • 9
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • DOI 10.1074/jbc.273.43.28238
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem. 1998;273:28238-46. (Pubitemid 28496122)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.43 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 10
    • 34250722576 scopus 로고    scopus 로고
    • Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells
    • DOI 10.1159/000101776
    • Clement CM, Thomas LK, Mou Y, Croslan DR, Gibbons GH, Ford BD. Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells. J Vasc Res. 2007;44:303-12. (Pubitemid 46956833)
    • (2007) Journal of Vascular Research , vol.44 , Issue.4 , pp. 303-312
    • Clement, C.M.1    Thomas, L.K.2    Mou, Y.3    Croslan, D.R.4    Gibbons, G.H.5    Ford, B.D.6
  • 11
    • 0033393696 scopus 로고    scopus 로고
    • Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis
    • 1:CAS:528:DC%2BD3cXpsF2n 10600838
    • Russell KS, Stern DF, Polverini PJ, Bender JR. Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. Am J Physiol. 1999;277:H2205-11.
    • (1999) Am J Physiol , vol.277 , pp. 2205-2211
    • Russell, K.S.1    Stern, D.F.2    Polverini, P.J.3    Bender, J.R.4
  • 12
    • 33750347979 scopus 로고    scopus 로고
    • Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes
    • DOI 10.1016/j.yjmcc.2006.08.002, PII S0022282806007590
    • Timolati F, Ott D, Pentassuglia L, Giraud MN, Perriard JC, Suter TM, et al. Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol. 2006;41:845-54. (Pubitemid 44635571)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.5 , pp. 845-854
    • Timolati, F.1    Ott, D.2    Pentassuglia, L.3    Giraud, M.-N.4    Perriard, J.-C.5    Suter, T.M.6    Zuppinger, C.7
  • 13
    • 84878527495 scopus 로고    scopus 로고
    • Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro
    • 1:CAS:528:DC%2BC3sXmvF2isbw%3D 23603262
    • Fukazawa T, Matsumoto M, Imura T, Khalesi E, Kajiume T, Kawahara Y, et al. Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro. Neurosci Lett. 2013;545:29-34.
    • (2013) Neurosci Lett , vol.545 , pp. 29-34
    • Fukazawa, T.1    Matsumoto, M.2    Imura, T.3    Khalesi, E.4    Kajiume, T.5    Kawahara, Y.6
  • 14
    • 84896701623 scopus 로고    scopus 로고
    • Neuregulin-1β improves cardiac remodeling after myocardial infarction in swine
    • Abstract
    • Kasasbeh, E., Murphy, A., Ahmad, F.A., Tu, E., Williams, P., Nunnally, A., et al. Neuregulin-1β improves cardiac remodeling after myocardial infarction in swine. Circulation. 2011;124:Abstract 15531.
    • (2011) Circulation , vol.124 , pp. 15531
    • Kasasbeh, E.1    Murphy, A.2    Ahmad, A.F.3    Tu, E.4    Williams, P.5    Nunnally, A.6
  • 15
    • 84875070234 scopus 로고    scopus 로고
    • ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions
    • 1:CAS:528:DC%2BC3sXkt1aguw%3D%3D 23261977
    • Pentassuglia L, Sawyer DB. ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions. Biochim Biophys Acta. 2013;1833:909-16.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 909-916
    • Pentassuglia, L.1    Sawyer, D.B.2
  • 16
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1β and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity
    • DOI 10.1161/01.CIR.0000013839.41224.1C
    • Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation. 2002;105:1551-4. (Pubitemid 34297631)
    • (2002) Circulation , vol.105 , Issue.13 , pp. 1551-1554
    • Sawyer, D.B.1    Zuppinger, C.2    Miller, T.A.3    Eppenberger, H.M.4    Suter, T.M.5
  • 17
    • 0032714208 scopus 로고    scopus 로고
    • NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK
    • 1:CAS:528:DyaK1MXns1yrtrc%3D 10564160
    • Baliga RR, Pimental DR, Zhao YY, Simmons WW, Marchionni MA, Sawyer DB, et al. NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK. Am J Physiol. 1999;277:H2026-37.
    • (1999) Am J Physiol , vol.277 , pp. 2026-2037
    • Baliga, R.R.1    Pimental, D.R.2    Zhao, Y.Y.3    Simmons, W.W.4    Marchionni, M.A.5    Sawyer, D.B.6
  • 18
    • 10944236872 scopus 로고    scopus 로고
    • Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1β/erbB4 signaling
    • DOI 10.1074/jbc.M408662200
    • Kuramochi Y, Cote GM, Guo X, Lebrasseur NK, Cui L, Liao R, et al. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem. 2004;279:51141-7. (Pubitemid 40017856)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.49 , pp. 51141-51147
    • Kuramochi, Y.1    Cote, G.M.2    Guo, X.3    Lebrasseur, N.K.4    Cui, L.5    Liao, R.6    Sawyer, D.B.7
  • 19
    • 0032562770 scopus 로고    scopus 로고
    • Neuregulins promote survival and growth of cardiac myocytes: Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    • DOI 10.1074/jbc.273.17.10261
    • Zhao YY, Sawyer DB, Baliga RR, Opel DJ, Han X, Marchionni MA, et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998;273:10261-9. (Pubitemid 28227629)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.17 , pp. 10261-10269
    • Zhao, Y.-Y.1    Sawyer, D.R.2    Baliga, R.R.3    Opel, D.J.4    Han, X.5    Marchionni, M.A.6    Kelly, R.A.7
  • 20
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • DOI 10.1016/j.yjmcc.2006.04.007, PII S0022282806005347
    • Kuramochi Y, Guo X, Sawyer DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol. 2006;41:228-35. (Pubitemid 44080212)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.2 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 21
    • 1642458136 scopus 로고    scopus 로고
    • Neuregulin-1 Induces a Negative Inotropic Effect in Cardiac Muscle: Role of Nitric Oxide Synthase
    • DOI 10.1161/01.CIR.0000114521.88547.5E
    • Lemmens K, Fransen P, Sys SU, Brutsaert DL, De Keulenaer GW. Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase. Circulation. 2004;109:324-6. (Pubitemid 38133898)
    • (2004) Circulation , vol.109 , Issue.3 , pp. 324-326
    • Lemmens, K.1    Fransen, P.2    Sys, S.U.3    Brutsaert, D.L.4    De Keulenaer, G.W.5
  • 22
    • 78149338262 scopus 로고    scopus 로고
    • Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes
    • 1:CAS:528:DC%2BC3cXhsVSltLrI 20634213
    • Brero A, Ramella R, Fitou A, Dati C, Alloatti G, Gallo MP, et al. Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes. Cardiovasc Res. 2010;88:443-52.
    • (2010) Cardiovasc Res , vol.88 , pp. 443-452
    • Brero, A.1    Ramella, R.2    Fitou, A.3    Dati, C.4    Alloatti, G.5    Gallo, M.P.6
  • 23
    • 84871801744 scopus 로고    scopus 로고
    • Uncoupled eNOS annihilates neuregulin-1beta-induced cardioprotection: A novel mechanism in pharmacological postconditioning in myocardial infarction
    • 1:CAS:528:DC%2BC38XhvV2ks7jI 23065382 This study made the interesting observation that NRG administered during ischemia and prior to reperfusion increases infarct size. It went on to show that this effect is due to enhancing ROS formation by activating uncoupled nitric oxide synthase (NOS). Either removing eNOS or improving coupling through coadministration of L-arginine as a substrate for eNOS converted NRG to a cardioprotective lingand, likely through GSK3β inactivation
    • •• Ebner B, Lange SA, Eckert T, Wischniowski C, Ebner A, Braun-Dullaeus RC, et al. Uncoupled eNOS annihilates neuregulin-1beta-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction. Mol Cell Biochem. 2013;373:115-23. This study made the interesting observation that NRG administered during ischemia and prior to reperfusion increases infarct size. It went on to show that this effect is due to enhancing ROS formation by activating uncoupled nitric oxide synthase (NOS). Either removing eNOS or improving coupling through coadministration of L-arginine as a substrate for eNOS converted NRG to a cardioprotective lingand, likely through GSK3β inactivation.
    • (2013) Mol Cell Biochem , vol.373 , pp. 115-123
    • Ebner, B.1    Lange, S.A.2    Eckert, T.3    Wischniowski, C.4    Ebner, A.5    Braun-Dullaeus, R.C.6
  • 24
    • 77958086724 scopus 로고    scopus 로고
    • Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin
    • 1:CAS:528:DC%2BC3cXhtlShsLfK 20615916
    • Gu X, Liu X, Xu D, Li X, Yan M, Qi Y, et al. Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. Cardiovasc Res. 2010;88:334-43.
    • (2010) Cardiovasc Res , vol.88 , pp. 334-343
    • Gu, X.1    Liu, X.2    Xu, D.3    Li, X.4    Yan, M.5    Qi, Y.6
  • 26
    • 27344447301 scopus 로고    scopus 로고
    • Neuregulin-1α and β isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro
    • DOI 10.1016/j.yexcr.2005.08.017, PII S0014482705003939
    • Cote GM, Miller TA, Lebrasseur NK, Kuramochi Y, Sawyer DB. Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro. Exp Cell Res. 2005;311:135-46. (Pubitemid 41527182)
    • (2005) Experimental Cell Research , vol.311 , Issue.1 , pp. 135-146
    • Cote, G.M.1    Miller, T.A.2    LeBrasseur, N.K.3    Kuramochi, Y.4    Sawyer, D.B.5
  • 27
    • 0037405153 scopus 로고    scopus 로고
    • Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle
    • 1:CAS:528:DC%2BD3sXjvFGqtr4%3D 12519750
    • Lebrasseur NK, Cote GM, Miller TA, Fielding RA, Sawyer DB. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Am J Physiol Cell Physiol. 2003;284:C1149-55.
    • (2003) Am J Physiol Cell Physiol , vol.284 , pp. 1149-1155
    • Lebrasseur, N.K.1    Cote, G.M.2    Miller, T.A.3    Fielding, R.A.4    Sawyer, D.B.5
  • 28
    • 22044440607 scopus 로고    scopus 로고
    • Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression
    • DOI 10.1016/j.nbd.2005.01.027, PII S0969996105000379
    • Xu Z, Ford GD, Croslan DR, Jiang J, Gates A, Allen R, et al. Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression. Neurobiol Dis. 2005;19:461-70. (Pubitemid 40968059)
    • (2005) Neurobiology of Disease , vol.19 , Issue.3 , pp. 461-470
    • Xu, Z.1    Ford, G.D.2    Croslan, D.R.3    Jiang, J.4    Gates, A.5    Allen, R.6    Ford, B.D.7
  • 29
    • 3042512308 scopus 로고    scopus 로고
    • Neuregulin-1 reduces ischemia-induced brain damage in rats
    • DOI 10.1016/j.neurobiolaging.2003.10.012, PII S0197458003002252
    • Shyu WC, Lin SZ, Chiang MF, Yang HI, Thajeb P, Li H. Neuregulin-1 reduces ischemia-induced brain damage in rats. Neurobiol Aging. 2004;25:935-44. (Pubitemid 38813173)
    • (2004) Neurobiology of Aging , vol.25 , Issue.7 , pp. 935-944
    • Shyu, W.-C.1    Lin, S.-Z.2    Chiang, M.-F.3    Yang, H.-I.4    Thajeb, P.5    Li, H.6
  • 30
    • 6044220229 scopus 로고    scopus 로고
    • Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke
    • DOI 10.1016/j.bbrc.2004.07.149, PII S0006291X04016274
    • Xu Z, Jiang J, Ford G, Ford BD. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochem Biophys Res Commun. 2004;322:440-6. (Pubitemid 39490323)
    • (2004) Biochemical and Biophysical Research Communications , vol.322 , Issue.2 , pp. 440-446
    • Xu, Z.1    Jiang, J.2    Ford, G.3    Ford, B.D.4
  • 31
    • 84863265688 scopus 로고    scopus 로고
    • Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis
    • 1:CAS:528:DC%2BC38XivVOmtL8%3D 22200588 These investigators defined a role for endothelial-derived NRG as an important mediator of ischemia-induced angiogenesis in peripheral vascular disease. These findings have clear therapeutic implications that have yet to be explored
    • • Hedhli N, Dobrucki LW, Kalinowski A, Zhuang ZW, Wu X, Russell 3rd RR, et al. Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis. Cardiovasc Res. 2012;93:516-24. These investigators defined a role for endothelial-derived NRG as an important mediator of ischemia-induced angiogenesis in peripheral vascular disease. These findings have clear therapeutic implications that have yet to be explored.
    • (2012) Cardiovasc Res , vol.93 , pp. 516-524
    • Hedhli, N.1    Dobrucki, L.W.2    Kalinowski, A.3    Zhuang, Z.W.4    Wu, X.5    Russell III, R.R.6
  • 32
    • 79958172866 scopus 로고    scopus 로고
    • Endothelium-derived neuregulin protects the heart against ischemic injury
    • 1:CAS:528:DC%2BC3MXmsVCrsbg%3D 3104502 21555713 These investigators used endothelial-specific ablation of NRG to demonstrate a role for endogenous cardiac NRG in the protection of the heart from ischemic injury. The elegant work sets the stage to explore how endogenous and exogenous recombinant neuregulin might be used to enhance recovery from myocardial infarction
    • •• Hedhli N, Huang Q, Kalinowski A, Palmeri M, Hu X, Russell RR, et al. Endothelium-derived neuregulin protects the heart against ischemic injury. Circulation. 2011;123:2254-62. These investigators used endothelial-specific ablation of NRG to demonstrate a role for endogenous cardiac NRG in the protection of the heart from ischemic injury. The elegant work sets the stage to explore how endogenous and exogenous recombinant neuregulin might be used to enhance recovery from myocardial infarction.
    • (2011) Circulation , vol.123 , pp. 2254-2262
    • Hedhli, N.1    Huang, Q.2    Kalinowski, A.3    Palmeri, M.4    Hu, X.5    Russell, R.R.6
  • 33
    • 63049089461 scopus 로고    scopus 로고
    • Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes
    • 1:CAS:528:DC%2BD1MXktF2ktrk%3D 19331811
    • Pentassuglia L, Graf M, Lane H, Kuramochi Y, Cote G, Timolati F, et al. Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes. Exp Cell Res. 2009;315:1302-12.
    • (2009) Exp Cell Res , vol.315 , pp. 1302-1312
    • Pentassuglia, L.1    Graf, M.2    Lane, H.3    Kuramochi, Y.4    Cote, G.5    Timolati, F.6
  • 34
    • 78650612002 scopus 로고    scopus 로고
    • Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    • 1:CAS:528:DC%2BC3MXhsFKisb4%3D
    • Fang SJ, Wu XS, Han ZH, Zhang XX, Wang CM, Li XY, et al. Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Chin Med J (Engl). 2010;123:3597-604.
    • (2010) Chin Med J (Engl) , vol.123 , pp. 3597-3604
    • Fang, S.J.1    Wu, X.S.2    Han, Z.H.3    Zhang, X.X.4    Wang, C.M.5    Li, X.Y.6
  • 35
    • 0033609458 scopus 로고    scopus 로고
    • Neuregulin in cardiac hypertrophy in rats with aortic stenosis: Differential expression of erbB2 and erbB4 receptors
    • Rohrbach S, Yan X, Weinberg EO, Hasan F, Bartunek J, Marchionni MA, et al. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation. 1999;100:407-12. (Pubitemid 29362412)
    • (1999) Circulation , vol.100 , Issue.4 , pp. 407-412
    • Rohrbach, S.1    Yan, X.2    Weinberg, E.O.3    Hasan, F.4    Bartunek, J.5    Marchionni, M.A.6    Lorell, B.H.7
  • 36
    • 84866013214 scopus 로고    scopus 로고
    • Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy
    • 1:CAS:528:DC%2BC38Xhtlamtb7F 22285193
    • Gui C, Zhu L, Hu M, Lei L, Long Q. Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy. Cardiovasc Pathol. 2012;21:414-20.
    • (2012) Cardiovasc Pathol , vol.21 , pp. 414-420
    • Gui, C.1    Zhu, L.2    Hu, M.3    Lei, L.4    Long, Q.5
  • 37
    • 25144465666 scopus 로고    scopus 로고
    • Neuregulin receptors erbB2 and erbB4in failing human myocardium. Depressed expression and attenuated activation
    • DOI 10.1007/s00395-005-0514-4
    • Rohrbach S, Niemann B, Silber RE, Holtz J. Neuregulin receptors erbB2 and erbB4 in failing human myocardium - depressed expression and attenuated activation. Basic Res Cardiol. 2005;100:240-9. (Pubitemid 41348815)
    • (2005) Basic Research in Cardiology , vol.100 , Issue.3 , pp. 240-249
    • Rohrbach, S.1    Niemann, B.2    Silber, R.-E.3    Holtz, J.4
  • 38
    • 16844371490 scopus 로고    scopus 로고
    • Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes
    • 1:CAS:528:DC%2BD2MXislygt78%3D 15671027
    • Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, et al. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005;280:13148-52.
    • (2005) J Biol Chem , vol.280 , pp. 13148-13152
    • Peng, X.1    Guo, X.2    Borkan, S.C.3    Bharti, A.4    Kuramochi, Y.5    Calderwood, S.6
  • 39
    • 84871859703 scopus 로고    scopus 로고
    • Cardiac side effects of anticancer treatments: New mechanistic insights
    • 1:CAS:528:DC%2BC38XhtFWnsbzO 3693763 22752360
    • Geisberg C, Pentassuglia L, Sawyer DB. Cardiac side effects of anticancer treatments: new mechanistic insights. Curr Heart Fail Rep. 2012;9:211-8.
    • (2012) Curr Heart Fail Rep , vol.9 , pp. 211-218
    • Geisberg, C.1    Pentassuglia, L.2    Sawyer, D.B.3
  • 46
    • 61749084637 scopus 로고    scopus 로고
    • Management of cardiac health in trastuzumab-treated patients with breast cancer: Updated United Kingdom National Cancer Research Institute recommendations for monitoring
    • 1:CAS:528:DC%2BD1MXisFentb8%3D 2653760 19259090
    • Jones AL, Barlow M, Barrett-Lee PJ, Canney PA, Gilmour IM, Robb SD, et al. Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoring. Br J Cancer. 2009;100:684-92.
    • (2009) Br J Cancer , vol.100 , pp. 684-692
    • Jones, A.L.1    Barlow, M.2    Barrett-Lee, P.J.3    Canney, P.A.4    Gilmour, I.M.5    Robb, S.D.6
  • 47
    • 84875693714 scopus 로고    scopus 로고
    • Cardiac testing to manage cardiovascular risk in cancer patients
    • 23540740
    • Davis M, Witteles RM. Cardiac testing to manage cardiovascular risk in cancer patients. Semin Oncol. 2013;40:147-55.
    • (2013) Semin Oncol , vol.40 , pp. 147-155
    • Davis, M.1    Witteles, R.M.2
  • 49
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • 1:CAS:528:DC%2BD1MXhtVSgtrzF 19632177
    • Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138:257-70.
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kuhn, B.4
  • 51
    • 84863368665 scopus 로고    scopus 로고
    • Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure
    • 1:CAS:528:DC%2BC38XlvFSgsrk%3D
    • Guo YF, Zhang XX, Liu Y, Duan HY, Jie BZ, Wu XS. Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure. Chin Med J (Engl). 2012;125:807-14.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 807-814
    • Guo, Y.F.1    Zhang, X.X.2    Liu, Y.3    Duan, H.Y.4    Jie, B.Z.5    Wu, X.S.6
  • 52
    • 84874289558 scopus 로고    scopus 로고
    • Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1beta improves left ventricular function, gene and protein expression in rats after myocardial infarction
    • 1:CAS:528:DC%2BC3sXjs12gurw%3D 3578842 23437060 In this study, the effects of recombinant NRG were examined in a rat model of cardiac remodeling after myocardial infarction and were found to improve cardiac function in concert with suppressing/reversing a number of the protein and gene expression changes that occur in chronic heart failure
    • • Hill MF, Patel AV, Murphy A, Smith HM, Galindo CL, Pentassuglia L, et al. Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1beta improves left ventricular function, gene and protein expression in rats after myocardial infarction. PLoS One. 2013;8:e55741. In this study, the effects of recombinant NRG were examined in a rat model of cardiac remodeling after myocardial infarction and were found to improve cardiac function in concert with suppressing/reversing a number of the protein and gene expression changes that occur in chronic heart failure.
    • (2013) PLoS One , vol.8 , pp. 55741
    • Hill, M.F.1    Patel, A.V.2    Murphy, A.3    Smith, H.M.4    Galindo, C.L.5    Pentassuglia, L.6
  • 53
    • 79960888603 scopus 로고    scopus 로고
    • Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats
    • 3170868 21798071
    • Li B, Zheng Z, Wei Y, Wang M, Peng J, Kang T, et al. Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats. Cardiovasc Diabetol. 2011;10:69.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 69
    • Li, B.1    Zheng, Z.2    Wei, Y.3    Wang, M.4    Peng, J.5    Kang, T.6
  • 54
    • 84867579183 scopus 로고    scopus 로고
    • Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction
    • 22968213
    • Xiao J, Li B, Zheng Z, Wang M, Peng J, Li Y, et al. Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction. Coron Artery Dis. 2012;23:460-8.
    • (2012) Coron Artery Dis , vol.23 , pp. 460-468
    • Xiao, J.1    Li, B.2    Zheng, Z.3    Wang, M.4    Peng, J.5    Li, Y.6
  • 55
    • 77952317892 scopus 로고    scopus 로고
    • A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
    • 1:CAS:528:DC%2BC3cXns1GisLY%3D 20430261
    • Gao R, Zhang J, Cheng L, Wu X, Dong W, Yang X, et al. A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol. 2010;55:1907-14.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1907-1914
    • Gao, R.1    Zhang, J.2    Cheng, L.3    Wu, X.4    Dong, W.5    Yang, X.6
  • 56
    • 78650412123 scopus 로고    scopus 로고
    • Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
    • 1:CAS:528:DC%2BC3cXhsF2rs7nP 20810473 In this clinical trial, the investigators define the hemodynamic response to recombinant NRG, showing its inodilator properties. Interestingly, the treatment was associated with improved myocardial function chronically that was most pronounced in the intermediate dose group
    • •• Jabbour A, Hayward CS, Keogh AM, Kotlyar E, McCrohon JA, England JF, et al. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur J Heart Fail. 2011;13:83-92. In this clinical trial, the investigators define the hemodynamic response to recombinant NRG, showing its inodilator properties. Interestingly, the treatment was associated with improved myocardial function chronically that was most pronounced in the intermediate dose group.
    • (2011) Eur J Heart Fail , vol.13 , pp. 83-92
    • Jabbour, A.1    Hayward, C.S.2    Keogh, A.M.3    Kotlyar, E.4    McCrohon, J.A.5    England, J.F.6
  • 57
    • 67650133506 scopus 로고    scopus 로고
    • Serum neuregulin-1beta as a biomarker of cardiovascular fitness
    • 1:CAS:528:DC%2BD1MXptFSmurk%3D 2903891 20634924
    • Moondra V, Sarma S, Buxton T, Safa R, Cote G, Storer T, et al. Serum neuregulin-1beta as a biomarker of cardiovascular fitness. Open Biomark J. 2009;2:1-5.
    • (2009) Open Biomark J , vol.2 , pp. 1-5
    • Moondra, V.1    Sarma, S.2    Buxton, T.3    Safa, R.4    Cote, G.5    Storer, T.6
  • 58
    • 68249087127 scopus 로고    scopus 로고
    • Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    • 1:CAS:528:DC%2BD1MXos1ent7c%3D 2741393 19597049
    • Ky B, Kimmel SE, Safa RN, Putt ME, Sweitzer NK, Fang JC, et al. Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation. 2009;120:310-7.
    • (2009) Circulation , vol.120 , pp. 310-317
    • Ky, B.1    Kimmel, S.E.2    Safa, R.N.3    Putt, M.E.4    Sweitzer, N.K.5    Fang, J.C.6
  • 59
    • 81855175973 scopus 로고    scopus 로고
    • Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia
    • 3217257 22027878
    • Geisberg CA, Wang G, Safa RN, Smith HM, Anderson B, Peng XY, et al. Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia. Coron Artery Dis. 2011;22:577-82.
    • (2011) Coron Artery Dis , vol.22 , pp. 577-582
    • Geisberg, C.A.1    Wang, G.2    Safa, R.N.3    Smith, H.M.4    Anderson, B.5    Peng, X.Y.6
  • 60
    • 84871853849 scopus 로고    scopus 로고
    • Circulating neuregulin during the transition from stage A to stage B/C heart failure in a breast cancer cohort
    • 1:CAS:528:DC%2BC3sXhsFOrug%3D%3D 3562720 23273589
    • Geisberg CA, Abdallah WM, da Silva M, Silverstein C, Smith HM, Abramson V, et al. Circulating neuregulin during the transition from stage A to stage B/C heart failure in a breast cancer cohort. J Card Fail. 2013;19:10-5.
    • (2013) J Card Fail , vol.19 , pp. 10-15
    • Geisberg, C.A.1    Abdallah, W.M.2    Da Silva, M.3    Silverstein, C.4    Smith, H.M.5    Abramson, V.6
  • 61
    • 84885582950 scopus 로고    scopus 로고
    • Serum neuregulin-1beta levels are positively correlated with VEGF and Angiopoietin-1 levels in patients with diabetes and unstable angina pectoris
    • •• Zeng, Z., Gui, C., Nong, Q., Du, F., Zhu, L. Serum neuregulin-1beta levels are positively correlated with VEGF and Angiopoietin-1 levels in patients with diabetes and unstable angina pectoris. Int J Cardiol. 2013. On the basis of animal studies, one might predict that NRG is released by ischemia, even before myocardial injury. These authors measured serum NRG in patients with unstable angina and provide evidence to support this idea. The potential of NRG as a biomarker of ischemia is further supported by Ref. 50.
    • (2013) Int J Cardiol.
    • Zeng, Z.1    Gui, C.2    Nong, Q.3    Du, F.4    Zhu, L.5
  • 62
    • 84879501615 scopus 로고    scopus 로고
    • A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death
    • 23524320
    • Huertas-Vazquez A, Teodorescu C, Reinier K, Uy-Evanado A, Chugh H, Jerger K, et al. A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death. Heart Rhythm. 2013;10:994-8.
    • (2013) Heart Rhythm , vol.10 , pp. 994-998
    • Huertas-Vazquez, A.1    Teodorescu, C.2    Reinier, K.3    Uy-Evanado, A.4    Chugh, H.5    Jerger, K.6
  • 65
    • 33845268661 scopus 로고    scopus 로고
    • Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls [1]
    • DOI 10.1038/sj.mp.4001878, PII 4001878
    • Nicodemus KK, Luna A, Vakkalanka R, Goldberg T, Egan M, Straub RE, et al. Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls. Mol Psychiatry. 2006;11:1062-5. (Pubitemid 44863428)
    • (2006) Molecular Psychiatry , vol.11 , Issue.12 , pp. 1062-1065
    • Nicodemus, K.K.1    Luna, A.2    Vakkalanka, R.3    Goldberg, T.4    Egan, M.5    Straub, R.E.6    Weinberger, D.R.7
  • 68
    • 79960710828 scopus 로고    scopus 로고
    • Sudden deaths in psychiatric patients
    • 3305794 21672496
    • Manu P, Kane JM, Correll CU. Sudden deaths in psychiatric patients. J Clin Psychiatry. 2011;72:936-41.
    • (2011) J Clin Psychiatry , vol.72 , pp. 936-941
    • Manu, P.1    Kane, J.M.2    Correll, C.U.3
  • 69
    • 0028792486 scopus 로고
    • Neuregulins and their receptors
    • 1:CAS:528:DyaK2MXps1yntL4%3D 8580712
    • Carraway 3rd KL, Burden SJ. Neuregulins and their receptors. Curr Opin Neurobiol. 1995;5:606-12.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 606-612
    • Carraway III, K.L.1    Burden, S.J.2
  • 70
    • 84896733914 scopus 로고    scopus 로고
    • Neuregulin-1β Inhibits TGFβ-induced Cardiofibroblast to Myofibroblast Transition
    • Abstract 302
    • Galindo, C., Truc-Tran, L., Ryzhov, S., Feoktistov, I., Sawyer, D.B. Neuregulin-1β Inhibits TGFβ-induced Cardiofibroblast to Myofibroblast Transition. Cardiovasc Res. 2013;113:Abstract 302.
    • (2013) Cardiovasc Res , vol.113
    • Galindo, C.1    Truc-Tran, L.2    Ryzhov, S.3    Feoktistov, I.4    Sawyer, B.D.5
  • 71
    • 84896730609 scopus 로고    scopus 로고
    • Evaluation of cardiac function in symptomatic heart failure patients in a single infusion, Phase 1, dose escalation study of glial growth factor 2
    • Brittain, E., Muldowney, J., Geisberg, C., Caggiano, A., Eisen, A., Anderson, S., et al. Evaluation of cardiac function in symptomatic heart failure patients in a single infusion, Phase 1, dose escalation study of glial growth factor 2. J Am Coll Cardiol. 2013;61.
    • (2013) J Am Coll Cardiol , pp. 61
    • Brittain, E.1    Muldowney, J.2    Geisberg, C.3    Caggiano, A.4    Eisen, A.5    Anderson, S.6
  • 72
    • 84896702497 scopus 로고    scopus 로고
    • Safety and tolerability of glial growth factor 2 in patients with chronic heart failure: A phase i single dose escalation study
    • Lenihan, D.J., Anderson, S., Geisberg, C., Caggiano, A., Eisen, A., Brittain, E., et al. Safety and tolerability of glial growth factor 2 in patients with chronic heart failure: a phase I single dose escalation study. J Am Coll Cardiol. 2013;61.
    • (2013) J Am Coll Cardiol , vol.61
    • Lenihan, J.D.1    Anderson, S.2    Geisberg, C.3    Caggiano, A.4    Eisen, A.5    Brittain, E.E.6
  • 73
    • 84875288392 scopus 로고    scopus 로고
    • Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure
    • 1:CAS:528:DC%2BC3sXotFCltLs%3D 3617023 23530877
    • Odiete O, Konik EA, Sawyer DB, Hill MF. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure. Cardiovasc Diabetol. 2013;12:52.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 52
    • Odiete, O.1    Konik, E.A.2    Sawyer, D.B.3    Hill, M.F.4
  • 75
    • 84880113102 scopus 로고    scopus 로고
    • An engineered bivalent neuregulin protects against Doxorubicin-induced cardiotoxicity with reduced proneoplastic potential
    • 1:CAS:528:DC%2BC3sXhtFSms7vM 23757312 These investigators engineered NRG to favor ErbB4 or ErbB3 homodimer formation, with the goal of removing ErbB2 activation during NRG stimulation. They provide intriguing evidence that such an approach can protect the heart and limit tumor growth
    • •• Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, et al. An engineered bivalent neuregulin protects against Doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013;128:152-61. These investigators engineered NRG to favor ErbB4 or ErbB3 homodimer formation, with the goal of removing ErbB2 activation during NRG stimulation. They provide intriguing evidence that such an approach can protect the heart and limit tumor growth.
    • (2013) Circulation , vol.128 , pp. 152-161
    • Jay, S.M.1    Murthy, A.C.2    Hawkins, J.F.3    Wortzel, J.R.4    Steinhauser, M.L.5    Alvarez, L.M.6
  • 76
    • 84880117174 scopus 로고    scopus 로고
    • Mechanism-based engineering against anthracycline cardiotoxicity
    • 23757311
    • Force T, Wang Y. Mechanism-based engineering against anthracycline cardiotoxicity. Circulation. 2013;128:98-100.
    • (2013) Circulation , vol.128 , pp. 98-100
    • Force, T.1    Wang, Y.2
  • 77
    • 79960995385 scopus 로고    scopus 로고
    • Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes
    • 1:CAS:528:DC%2BC3MXpsVOms7Y%3D 21622572
    • Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, et al. Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. J Biol Chem. 2011;286:27729-40.
    • (2011) J Biol Chem , vol.286 , pp. 27729-27740
    • Jay, S.M.1    Kurtagic, E.2    Alvarez, L.M.3    De Picciotto, S.4    Sanchez, E.5    Hawkins, J.F.6
  • 82
    • 84867335480 scopus 로고    scopus 로고
    • Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore
    • 1:CAS:528:DC%2BC38XhsVCjsrjN 22886427
    • Jie B, Zhang X, Wu X, Xin Y, Liu Y, Guo Y. Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore. Mol Cell Biochem. 2012;370:35-43.
    • (2012) Mol Cell Biochem , vol.370 , pp. 35-43
    • Jie, B.1    Zhang, X.2    Wu, X.3    Xin, Y.4    Liu, Y.5    Guo, Y.6
  • 83
    • 34547367135 scopus 로고    scopus 로고
    • Effects of neuregulin on cardiac myocyte apoptosis and PI-3K signal transduction pathway in rapid pacing-induced heart failure in rhesus monkeys
    • 1:CAS:528:DC%2BD1cXosVWrsL4%3D 17611315
    • Li J, Qiang O, Wang L. Effects of neuregulin on cardiac myocyte apoptosis and PI-3K signal transduction pathway in rapid pacing-induced heart failure in rhesus monkeys. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007;32:408-12.
    • (2007) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.32 , pp. 408-412
    • Li, J.1    Qiang, O.2    Wang, L.3
  • 84
    • 14744291620 scopus 로고    scopus 로고
    • Apoptosis-modulating interaction of the neuregulin/erbB pathway with antracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes
    • DOI 10.1016/j.yjmcc.2004.12.013
    • Rohrbach S, Muller-Werdan U, Werdan K, Koch S, Gellerich NF, Holtz J. Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes. J Mol Cell Cardiol. 2005;38:485-93. (Pubitemid 40331939)
    • (2005) Journal of Molecular and Cellular Cardiology , vol.38 , Issue.3 , pp. 485-493
    • Rohrbach, S.1    Muller-Werdan, U.2    Werdan, K.3    Koch, S.4    Gellerich, N.F.5    Holtz, J.6
  • 85
    • 34247149885 scopus 로고    scopus 로고
    • Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes
    • DOI 10.1016/j.yexcr.2007.02.007, PII S0014482707000699
    • Pentassuglia L, Timolati F, Seifriz F, Abudukadier K, Suter TM, Zuppinger C. Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes. Exp Cell Res. 2007;313:1588-601. (Pubitemid 46589436)
    • (2007) Experimental Cell Research , vol.313 , Issue.8 , pp. 1588-1601
    • Pentassuglia, L.1    Timolati, F.2    Seifriz, F.3    Abudukadier, K.4    Suter, T.M.5    Zuppinger, C.6
  • 86
    • 0036677402 scopus 로고    scopus 로고
    • Neuregulin-1 promotes formation of the murine cardiac conduction system
    • 1:CAS:528:DC%2BD38Xmt1Chsro%3D 124940 12149465
    • Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, et al. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A. 2002;99:10464-9.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10464-10469
    • Rentschler, S.1    Zander, J.2    Meyers, K.3    France, D.4    Levine, R.5    Porter, G.6
  • 88
    • 0242636818 scopus 로고    scopus 로고
    • Prospects for Biological Cardiac Pacemaker Systems
    • DOI 10.1046/j.1460-9592.2003.00322.x
    • Ruhparwar A, Haverich A. Prospects for biological cardiac pacemaker systems. Pacing Clin Electrophysiol. 2003;26:2069-71. (Pubitemid 37433672)
    • (2003) PACE - Pacing and Clinical Electrophysiology , vol.26 , Issue.11 , pp. 2069-2071
    • Ruhparwar, A.1    Haverich, A.2
  • 89
    • 84876519894 scopus 로고    scopus 로고
    • Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis
    • 1:CAS:528:DC%2BC3sXjsVKhsL8%3D 23382327
    • Matsukawa R, Hirooka Y, Ito K, Sunagawa K. Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis. Am J Hypertens. 2013;26:51-7.
    • (2013) Am J Hypertens , vol.26 , pp. 51-57
    • Matsukawa, R.1    Hirooka, Y.2    Ito, K.3    Sunagawa, K.4
  • 90
    • 77954454429 scopus 로고    scopus 로고
    • Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells
    • 1:CAS:528:DC%2BC3cXptV2ku7k%3D 20215529
    • Kalinowski A, Plowes NJ, Huang Q, Berdejo-Izquierdo C, Russell RR, Russell KS. Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells. FASEB J. 2010;24:2567-75.
    • (2010) FASEB J , vol.24 , pp. 2567-2575
    • Kalinowski, A.1    Plowes, N.J.2    Huang, Q.3    Berdejo-Izquierdo, C.4    Russell, R.R.5    Russell, K.S.6
  • 92
    • 79955072413 scopus 로고    scopus 로고
    • Neuregulin-1beta regulation of embryonic endothelial progenitor cell survival
    • 1:CAS:528:DC%2BC3MXlt1OksLo%3D 21239627 This work demonstrates that a subpopulation of monocytes in the circulation that have been associated with cardiac repair respond to NRG with enhanced survival. Whether this set of cells is activated by NRG during cardiac injury/stress and mediates cardiac repair remains an open question
    • • Safa RN, Peng XY, Pentassuglia L, Lim CC, Lamparter M, Silverstein C, et al. Neuregulin-1beta regulation of embryonic endothelial progenitor cell survival. Am J Physiol Heart Circ Physiol. 2011;300:H1311-9. This work demonstrates that a subpopulation of monocytes in the circulation that have been associated with cardiac repair respond to NRG with enhanced survival. Whether this set of cells is activated by NRG during cardiac injury/stress and mediates cardiac repair remains an open question.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , pp. 1311-1319
    • Safa, R.N.1    Peng, X.Y.2    Pentassuglia, L.3    Lim, C.C.4    Lamparter, M.5    Silverstein, C.6
  • 94
    • 69249229915 scopus 로고    scopus 로고
    • Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat
    • 18830828
    • Li Q, Zhang R, Ge YL, Mei YW, Guo YL. Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat. J Mol Neurosci. 2009;38:207-15.
    • (2009) J Mol Neurosci , vol.38 , pp. 207-215
    • Li, Q.1    Zhang, R.2    Ge, Y.L.3    Mei, Y.W.4    Guo, Y.L.5
  • 96
    • 84862241986 scopus 로고    scopus 로고
    • Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury
    • 3389802 22773936
    • Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, et al. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012;3:S119-24.
    • (2012) Transl Stroke Res , vol.3 , pp. 119-124
    • Lok, J.1    Zhao, S.2    Leung, W.3    Seo, J.H.4    Navaratna, D.5    Wang, X.6
  • 97
  • 98
    • 79955052182 scopus 로고    scopus 로고
    • Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy
    • 1:CAS:528:DC%2BC3MXjs1Gqsrs%3D 21186272
    • Lemmens K, Doggen K, De Keulenaer GW. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am J Physiol Heart Circ Physiol. 2011;300:H931-42.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , pp. 931-942
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 99
    • 84862794583 scopus 로고    scopus 로고
    • Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts
    • 1:CAS:528:DC%2BC38XmtVejs7s%3D 22350758
    • Kim JS, Choi IG, Lee BC, Park JB, Kim JH, Jeong JH, et al. Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts. Mol Cell Biochem. 2012;365:181-9.
    • (2012) Mol Cell Biochem , vol.365 , pp. 181-189
    • Kim, J.S.1    Choi, I.G.2    Lee, B.C.3    Park, J.B.4    Kim, J.H.5    Jeong, J.H.6
  • 100
    • 0034687595 scopus 로고    scopus 로고
    • Plasma cytokine parameters and mortality in patients with chronic heart failure
    • 1:CAS:528:DC%2BD3MXitlSltg%3D%3D 11120695
    • Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, Liebenthal C, et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 2000;102:3060-7.
    • (2000) Circulation , vol.102 , pp. 3060-3067
    • Rauchhaus, M.1    Doehner, W.2    Francis, D.P.3    Davos, C.4    Kemp, M.5    Liebenthal, C.6
  • 102
    • 81455131591 scopus 로고    scopus 로고
    • Systemic inflammation and cell activation reflects morbidity in chronic heart failure
    • 1:CAS:528:DC%2BC3MXhsFSkt7bK 21924921
    • Dixon DL, Griggs KM, Bersten AD, De Pasquale CG. Systemic inflammation and cell activation reflects morbidity in chronic heart failure. Cytokine. 2011;56:593-9.
    • (2011) Cytokine , vol.56 , pp. 593-599
    • Dixon, D.L.1    Griggs, K.M.2    Bersten, A.D.3    De Pasquale, C.G.4
  • 103
    • 79955601433 scopus 로고    scopus 로고
    • The emerging role of innate immunity in the heart and vascular system: For whom the cell tolls
    • 1:CAS:528:DC%2BC3MXltl2gsrc%3D 3084988 21527743
    • Mann DL. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res. 2011;108:1133-45.
    • (2011) Circ Res , vol.108 , pp. 1133-1145
    • Mann, D.L.1
  • 106
    • 70149110196 scopus 로고    scopus 로고
    • Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    • 1:CAS:528:DC%2BD1MXhtVekt7%2FJ 19644050
    • Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, et al. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res. 2009;105:500-10.
    • (2009) Circ Res , vol.105 , pp. 500-510
    • Xu, G.1    Watanabe, T.2    Iso, Y.3    Koba, S.4    Sakai, T.5    Nagashima, M.6
  • 107
    • 4043110498 scopus 로고    scopus 로고
    • Neuregulins regulate cardiac parasympathetic activity: Muscarinic modulation of β-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
    • DOI 10.1161/01.CIR.0000138109.32748.80
    • Okoshi K, Nakayama M, Yan X, Okoshi MP, Schuldt AJ, Marchionni MA, et al. Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion. Circulation. 2004;110:713-7. (Pubitemid 39056271)
    • (2004) Circulation , vol.110 , Issue.6 , pp. 713-717
    • Okoshi, K.1    Nakayama, M.2    Yan, X.3    Okoshi, M.P.4    Schuldt, A.J.T.5    Marchionni, M.A.6    Lorell, B.H.7
  • 108
    • 84862777623 scopus 로고    scopus 로고
    • Pathogenic involvement of heregulin-beta(1) in anti-atherogenesis
    • 1:CAS:528:DC%2BC38XjtF2jsL4%3D 22331010
    • Watanabe T, Sato K, Itoh F, Iso Y. Pathogenic involvement of heregulin-beta(1) in anti-atherogenesis. Regul Pept. 2012;175:11-4.
    • (2012) Regul Pept , vol.175 , pp. 11-14
    • Watanabe, T.1    Sato, K.2    Itoh, F.3    Iso, Y.4


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